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Title: Physical implications of so(2,1) symmetry in exact solutions for a self-repressing gene
Authors: RAMOS, Alexandre F.REINITZ, John
Citation: JOURNAL OF CHEMICAL PHYSICS, v.151, n.4, article ID 41101, 5p, 2019
Abstract: We chemically characterize the symmetries underlying the exact solutions of a stochastic negatively self-regulating gene. The breaking of symmetry at a low molecular number causes three effects. Two branches of the solution exist, having high and low switching rates, such that the low switching rate branch approaches deterministic behavior and the high switching rate branch exhibits sub-Fano behavior. The average protein number differs from the deterministically expected value. Bimodal probability distributions appear as the protein number becomes a readout of the ON/OFF state of the gene.
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Artigos e Materiais de Revistas Científicas - LIM/24
LIM/24 - Laboratório de Oncologia Experimental

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