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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorNEPOMUCENO, Andre C.
dc.contributor.authorFARIA, Jose C. de
dc.contributor.authorPOLITANI, Elisa L.
dc.contributor.authorSILVA, Eduardo G.
dc.contributor.authorSALOMONE, Raquel
dc.contributor.authorV, Marco Longo
dc.contributor.authorLIMA, Washington
dc.contributor.authorSALLES, Alessandra G.
dc.contributor.authorGEMPERLI, Rolf
dc.date.accessioned2019-11-06T18:45:17Z-
dc.date.available2019-11-06T18:45:17Z-
dc.date.issued2019
dc.identifier.citationMICROSURGERY, v.39, n.6, p.535-542, 2019
dc.identifier.issn0738-1085
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/33906-
dc.description.abstractIntroduction Muscle contraction generated by electrical impulses simultaneously originating from two different neural sources may be an interesting treatment alternative for long term facial palsy. An experimental model was designed to compare single and dual innervation of the gastrocnemius muscle (GM) in rats. Methods Fifty adult Wistar rats underwent transection of their right peroneal nerve and were divided into five groups (n = 10): control (C), tibial nerve section (TS), tibial nerve primary end-to-end neurorrhaphy (PEE), tibial nerve primary repair associated with end-to-side peroneal-to-tibial nerve transfer (PRES), and tibial nerve repair by convergent end-to-end (CEE) neurorrhaphy between the proximal stumps of the tibial and peroneal nerves to the distal stump of the tibial nerve. The outcomes were assessed 12 weeks after the experiment by walking track, electromyography, GM mass index, and histomorphometric analysis of the distal tibial nerve. Results The functional recovery of the PRES (-33.77 +/- 24.13) and CEE (-42.15 +/- 31.14) groups was greater (P < 0.003) than the PEE group (-80.26 +/- 17.20). The CEE group (18.35 +/- 7.84) showed greater amplitude (P = 0.006) than the PEE group (8.2 +/- 4.64). There was no difference in the muscle mass index among the reinnervation groups (P > 0.705). Histologic analysis revealed greater (P < 0.002) axonal density in the CEE group (126.70 +/- 15.01) compared to PEE (99.70 +/- 12.82) and PRES (92.00 +/- 19.17) groups. Conclusions The dual innervation techniques showed earlier and greater functional recovery of the GM than did the single innervation technique. The CEE group showed a 40% higher number of regenerated axons in the distal tibial nerve stump.eng
dc.description.sponsorshipNo financial support has been received from any organization that may have an interest in the submitted work
dc.language.isoeng
dc.publisherWILEYeng
dc.relation.ispartofMicrosurgery
dc.rightsrestrictedAccesseng
dc.subject.othernerve transfereng
dc.subject.otheraxonal regenerationeng
dc.subject.otherfacial reanimationeng
dc.subject.otherrepaireng
dc.subject.otherconduiteng
dc.subject.otherperonealeng
dc.titleConvergent end-to-end neurorrhaphy: An alternative technique for dual innervation of the gastrocnemius muscle in ratseng
dc.typearticleeng
dc.rights.holderCopyright WILEYeng
dc.identifier.doi10.1002/micr.30433
dc.identifier.pmid30706529
dc.subject.wosSurgeryeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
hcfmusp.author.externalV, Marco Longo:Univ Sao Paulo, Hosp Clin, Plast Surg Dept, Sao Paulo, SP, Brazil
hcfmusp.description.beginpage535
hcfmusp.description.endpage542
hcfmusp.description.issue6
hcfmusp.description.volume39
hcfmusp.origemWOS
hcfmusp.origem.idWOS:000486171800008
hcfmusp.origem.id2-s2.0-85060907991
hcfmusp.publisher.cityHOBOKENeng
hcfmusp.publisher.countryUSAeng
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dc.description.indexMEDLINEeng
dc.identifier.eissn1098-2752
hcfmusp.citation.scopus0-
hcfmusp.scopus.lastupdate2022-05-06-
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Artigos e Materiais de Revistas Científicas - FM/MCG
Departamento de Cirurgia - FM/MCG

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - HC/InRad
Instituto de Radiologia - HC/InRad

Artigos e Materiais de Revistas Científicas - LIM/04
LIM/04 - Laboratório de Microcirurgia


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