Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorNEPOMUCENO, Andre C.
dc.contributor.authorFARIA, Jose C. de
dc.contributor.authorPOLITANI, Elisa L.
dc.contributor.authorSILVA, Eduardo G.
dc.contributor.authorSALOMONE, Raquel
dc.contributor.authorV, Marco Longo
dc.contributor.authorLIMA, Washington
dc.contributor.authorSALLES, Alessandra G.
dc.contributor.authorGEMPERLI, Rolf
dc.identifier.citationMICROSURGERY, v.39, n.6, p.535-542, 2019
dc.description.abstractIntroduction Muscle contraction generated by electrical impulses simultaneously originating from two different neural sources may be an interesting treatment alternative for long term facial palsy. An experimental model was designed to compare single and dual innervation of the gastrocnemius muscle (GM) in rats. Methods Fifty adult Wistar rats underwent transection of their right peroneal nerve and were divided into five groups (n = 10): control (C), tibial nerve section (TS), tibial nerve primary end-to-end neurorrhaphy (PEE), tibial nerve primary repair associated with end-to-side peroneal-to-tibial nerve transfer (PRES), and tibial nerve repair by convergent end-to-end (CEE) neurorrhaphy between the proximal stumps of the tibial and peroneal nerves to the distal stump of the tibial nerve. The outcomes were assessed 12 weeks after the experiment by walking track, electromyography, GM mass index, and histomorphometric analysis of the distal tibial nerve. Results The functional recovery of the PRES (-33.77 +/- 24.13) and CEE (-42.15 +/- 31.14) groups was greater (P < 0.003) than the PEE group (-80.26 +/- 17.20). The CEE group (18.35 +/- 7.84) showed greater amplitude (P = 0.006) than the PEE group (8.2 +/- 4.64). There was no difference in the muscle mass index among the reinnervation groups (P > 0.705). Histologic analysis revealed greater (P < 0.002) axonal density in the CEE group (126.70 +/- 15.01) compared to PEE (99.70 +/- 12.82) and PRES (92.00 +/- 19.17) groups. Conclusions The dual innervation techniques showed earlier and greater functional recovery of the GM than did the single innervation technique. The CEE group showed a 40% higher number of regenerated axons in the distal tibial nerve stump.eng
dc.description.sponsorshipNo financial support has been received from any organization that may have an interest in the submitted work
dc.subject.othernerve transfereng
dc.subject.otheraxonal regenerationeng
dc.subject.otherfacial reanimationeng
dc.titleConvergent end-to-end neurorrhaphy: An alternative technique for dual innervation of the gastrocnemius muscle in ratseng
dc.rights.holderCopyright WILEYeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng, Marco Longo:Univ Sao Paulo, Hosp Clin, Plast Surg Dept, Sao Paulo, SP, Brazil
hcfmusp.relation.referenceBAIN JR, 1989, PLAST RECONSTR SURG, V83, P129, DOI 10.1097/00006534-198901000-00024eng
hcfmusp.relation.referenceBertelli JA, 2005, NEUROL RES, V27, P657, DOI 10.1179/016164105X18494eng
hcfmusp.relation.referenceBiglioli F, 2012, J PLAST RECONSTR AES, V65, P1343, DOI 10.1016/j.bjps.2012.04.030eng
hcfmusp.relation.referenceDamy SB, 2010, REV ASSOC MED BRAS, V56, P103, DOI 10.1590/S0104-42302010000100024eng
hcfmusp.relation.referencede Ruiter GCW, 2014, J NEUROSURG, V120, P493, DOI 10.3171/2013.8.JNS122300eng
hcfmusp.relation.referenceEren F, 2005, PLAST RECONSTR SURG, V116, P1697, DOI 10.1097/01.prs.0000186538.04622.7aeng
hcfmusp.relation.referenceFarber SJ, 2013, J HAND SURG-AM, V38A, P466, DOI 10.1016/j.jhsa.2012.12.020eng
hcfmusp.relation.referenceFaria JCM, 2007, ANN PLAS SURG, V59, P87, DOI 10.1097/
hcfmusp.relation.referenceFox IK, 2012, MICROSURG, V32, P552, DOI 10.1002/micr.22036eng
hcfmusp.relation.referenceFujiwara T, 2007, J NEUROSURG, V107, P821, DOI 10.3171/JNS-07/10/0821eng
hcfmusp.relation.referenceFurukawa H, 2008, J PLAST RECONSTR AES, V61, P257, DOI 10.1016/j.bjps.2007.01.075eng
hcfmusp.relation.referenceIsaacs JE, 2008, J RECONSTR MICROSURG, V24, P489, DOI 10.1055/s-0028-1088230eng
hcfmusp.relation.referenceJung JM, 2009, CLIN ORTHOP SURG, V1, P90, DOI 10.4055/cios.2009.1.2.90eng
hcfmusp.relation.referenceKalbermatten DF, 2009, J RECONSTR MICROSURG, V25, P27, DOI 10.1055/s-0028-1090619eng
hcfmusp.relation.referenceKemp SWP, 2010, EUR J NEUROSCI, V31, P1074, DOI 10.1111/j.1460-9568.2010.07130.xeng
hcfmusp.relation.referenceKilkenny C, 2010, PLOS BIOL, V8, DOI 10.1371/journal.pbio.1000412eng
hcfmusp.relation.referenceLadak A, 2013, NEUROSURGERY, V72, P1055, DOI 10.1227/01.neu.0000430600.51158.3eeng
hcfmusp.relation.referenceMACKINNON SE, 1991, MUSCLE NERVE, V14, P1116, DOI 10.1002/mus.880141113eng
hcfmusp.relation.referenceMACKINNON SE, 1986, J HAND SURG-AM, V11A, P888, DOI 10.1016/S0363-5023(86)80244-1eng
hcfmusp.relation.referenceFaria JCM, 2010, ANN PLAS SURG, V64, P31, DOI 10.1097/SAP.0b013e3181999ea9eng
hcfmusp.relation.referenceNepomuceno A. C., 2016, PLASTIC RECONSTRUC S, V4, P181, DOI [10.1097/01.GOX.0000503132.32709.c3, DOI 10.1097/01.GOX.0000503132.32709.C3]eng
hcfmusp.relation.referenceNepomuceno AC, 2016, ACTA CIR BRAS, V31, P542, DOI 10.1590/S0102-865020160080000007eng
hcfmusp.relation.referenceNie X, 2014, CELL BIOCHEM BIOPHYS, V68, P163, DOI 10.1007/s12013-013-9683-8eng
hcfmusp.relation.referenceProdanov D, 2008, BRAIN RES, V1233, P35, DOI 10.1016/j.brainres.2008.07.049eng
hcfmusp.relation.referenceRobinson LR, 2015, MUSCLE NERVE, V52, P321, DOI 10.1002/mus.24709eng
hcfmusp.relation.referenceRodriguez A, 2011, PLAST RECONSTR SURG, V127, P1155, DOI 10.1097/PRS.0b013e31820439f0eng
hcfmusp.relation.referenceSabatier MJ, 2011, CELLS TISSUES ORGANS, V193, P298, DOI 10.1159/000323677eng
hcfmusp.relation.referenceSalles GSS, 2013, ACTA CIR BRAS, V28, P512eng
hcfmusp.relation.referenceSocolovsky M, 2017, NEUROSURG FOCUS, V42, DOI 10.3171/2016.12.FOCUS16431eng
hcfmusp.relation.referenceSUNDERLAND S, 1990, MUSCLE NERVE, V13, P771, DOI 10.1002/mus.880130903eng
hcfmusp.relation.referenceTos P, 2000, MICROSURG, V20, P65, DOI 10.1002/(SICI)1098-2752(2000)20:2<65::AID-MICR4>3.0.CO;2-4eng
hcfmusp.relation.referenceUrso-Baiarda FG, 2007, PLAST RECONSTR SURG, V119, P1129, DOI 10.1097/01.prs.0000253451.50796.e3eng
hcfmusp.relation.referenceWood MD, 2011, ANN ANAT, V193, P321, DOI 10.1016/j.aanat.2011.04.008eng
Appears in Collections:

Artigos e Materiais de Revistas Científicas - FM/MCG
Departamento de Cirurgia - FM/MCG

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - HC/InRad
Instituto de Radiologia - HC/InRad

Artigos e Materiais de Revistas Científicas - LIM/04
LIM/04 - Laboratório de Microcirurgia

Files in This Item:
File Description SizeFormat 
  Restricted Access
publishedVersion (English)8.94 MBAdobe PDFView/Open Request a copy

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.