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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorTRITTO, Aline C.
dc.contributor.authorBUENO, Salomao
dc.contributor.authorRODRIGUES, Rosa M. P.
dc.contributor.authorGUALANO, Bruno
dc.contributor.authorROSCHEL, Hamilton
dc.contributor.authorARTIOLI, Guilherme G.
dc.identifier.citationINTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM, v.29, n.5, p.505-511, 2019
dc.description.abstractThis study evaluated the effects of beta-hydroxy-beta-methylbutyrate free acid (HMB-FA) and calcium salt (HMB-Ca) on strength, hypertrophy, and markers of muscle damage. In this randomized, double-blind, placebo-controlled study, 44 resistance-trained men (age: 26 +/- 4 years; body mass: 84.9 +/- 12.0 kg) consuming = 1.7 of protein received HMB-FA (3 g/day; n = 14), HMB-Ca (3 g/day; n = 15), or placebo (PL; cornstarch, 3 g/day; n = 15) for 12 weeks, while performing a periodized resistance training program. Before and after intervention, lean body mass (measured with dual X-ray absorptiometry), maximal dynamic strength (one-repetition maximum), knee extension maximal isometric strength (maximal voluntary isometric contraction [MVIC]), cross-sectional area (measured with ultrasound), and muscle soreness were assessed. MVIC was also measured 48 hr after the first and the last training sessions. All groups increased lean body mass (main time effect: p < .0001; HMB-FA: 1.8 +/- 1.8 kg; HMB-Ca: 0.8 +/- 1.4 kg; PL: 0.9 +/- 1.4 kg), cross-sectional area (main time effect: p < .0001; HMB-FA: 6.6 +/- 3.8%; HMB-Ca: 4.7 +/- 4.4%; PL: 6.9 +/- 3.8%), one-repetition maximum bench press (main time effect: p < .0001; HMB-FA: 14.8 +/- 8.4 kg; HMB-Ca: 11.8 +/- 7.4 kg; PL: 11.2 +/- 6.6 kg), MVIC (main time effect: p < .0001; HMB-FA: 34.4 +/- 39.3%; HMB-Ca: 32.3 +/- 27.4%; PL: 17.7 +/- 20.9%) after the intervention, but no differences between groups were shown. HMB-FA group showed greater leg press strength after the intervention than HMB-Ca and PL groups (Group x Time interaction: p < .05; HMB-FA: 47.7 +/- 31.2 kg; HMB-Ca: 43.8 +/- 31.7 kg; PL: 30.2 +/- 20.9 kg). MVIC measured 48 hr after the first and the last sessions showed no attenuation of force decline with supplementation. Muscle soreness following the first and last sessions was not different between groups. The authors concluded that neither HMB-Ca nor HMB-FA improved hypertrophy or reduced muscle damage in resistance-trained men undergoing resistance training ingesting optimal amounts of protein. HMB-FA but not HMB-Ca resulted in a statistically significant yet minor improvement on leg press one-repetition maximum.eng
dc.description.sponsorshipFAPESPFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2014/11948-8]
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior-Brazil (CAPES)CAPES [001]
dc.relation.ispartofInternational Journal of Sport Nutrition and Exercise Metabolism
dc.subjectmuscle damageeng
dc.subject.otherinduced muscle damageeng
dc.subject.otherhmb supplementationeng
dc.titleNegligible Effects of beta-Hydroxy-beta-Methylbutyrate Free Acid and Calcium Salt on Strength and Hypertrophic Responses to Resistance Training: A Randomized, Placebo-Controlled Studyeng
dc.rights.holderCopyright HUMAN KINETICS PUBL INCeng
dc.subject.wosNutrition & Dieteticseng
dc.subject.wosSport Scienceseng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng, Aline C.:Univ Sao Paulo, Appl Physiol & Nutr Res Grp, Sch Phys Educ & Sport, Sao Paulo, Brazil, Salomao:Univ Sao Paulo, Appl Physiol & Nutr Res Grp, Sch Phys Educ & Sport, Sao Paulo, Brazil, Hamilton:Univ Sao Paulo, Appl Physiol & Nutr Res Grp, Sch Phys Educ & Sport, Sao Paulo, Brazil, Guilherme G.:Univ Sao Paulo, Appl Physiol & Nutr Res Grp, Sch Phys Educ & Sport, Sao Paulo, Brazil
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Artigos e Materiais de Revistas Científicas - FM/MCM
Departamento de Clínica Médica - FM/MCM

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - LIM/17
LIM/17 - Laboratório de Investigação em Reumatologia

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