Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/33986
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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorANDRADE, Luciana Nogueira de Sousa
dc.contributor.authorOTAKE, Andreia Hanada
dc.contributor.authorCARDIM, Silvia Guedes Braga
dc.contributor.authorSILVA, Felipe I. Lelis da
dc.contributor.authorSAKAMOTO, Mariana Mari Ikoma
dc.contributor.authorFURUYA, Tatiane Katsue
dc.contributor.authorUNO, Miyuki
dc.contributor.authorPASINI, Fatima Solange
dc.contributor.authorCHAMMAS, Roger
dc.date.accessioned2019-11-06T18:46:42Z-
dc.date.available2019-11-06T18:46:42Z-
dc.date.issued2019
dc.identifier.citationSCIENTIFIC REPORTS, v.9, article ID 14482, 12p, 2019
dc.identifier.issn2045-2322
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/33986-
dc.description.abstractExtracellular vesicles (EVs) are emerging as key players in intercellular communication. EVs can transfer biological macromolecules to recipient cells, modulating various physiological and pathological processes. It has been shown that tumor cells secrete large amounts of EVs that can be taken up by malignant and stromal cells, dictating tumor progression. In this study, we investigated whether EVs secreted by melanoma cells in response to chemotherapy modulate tumor response to alkylating drugs. Our findings showed that human and murine melanoma cells secrete more EVs after treatment with temozolomide and cisplatin. We observed that EVs shed by melanoma cells after temozolomide treatment modify macrophage phenotype by skewing macrophage activation towards the M2 phenotype through upregulation of M2-marker genes. Moreover, these EVs were able to favor melanoma re-growth in vivo, which was accompanied by an increase in Arginase 1 and IL10 gene expression levels by stromal cells and an increase in genes related to DNA repair, cell survival and stemness in tumor cells. Taken together, this study suggests that EVs shed by tumor cells in response to chemotherapy promote tumor repopulation and treatment failure through cellular reprogramming in melanoma cells.eng
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior - Brasil (CAPES)CAPES [001]
dc.description.sponsorshipFapesp (Fundacao de Apoio a Pesquisa do Estado de Sao Paulo)Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2014/03742-0, 2018/01366-2]
dc.description.sponsorshipCNPq (Conselho Nacional de Desenvolvimento Cientifico e tecnologico)National Council for Scientific and Technological Development (CNPq)
dc.language.isoeng
dc.publisherNATURE PUBLISHING GROUPeng
dc.relation.ispartofScientific Reports
dc.rightsopenAccesseng
dc.subject.otherbreast-cancer cellseng
dc.subject.otherin-vitroeng
dc.subject.otherexosomeseng
dc.subject.othertumoreng
dc.subject.otherresistanceeng
dc.subject.otherphenotypeeng
dc.subject.otherangiogenesiseng
dc.subject.othermicroenvironmenteng
dc.subject.otherbiochemotherapyeng
dc.subject.othermacrophageseng
dc.titleExtracellular Vesicles Shedding Promotes Melanoma Growth in Response to Chemotherapyeng
dc.typearticleeng
dc.rights.holderCopyright NATURE PUBLISHING GROUPeng
dc.identifier.doi10.1038/s41598-019-50848-z
dc.identifier.pmid31597943
dc.subject.wosMultidisciplinary Scienceseng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
hcfmusp.author.externalSILVA, Felipe I. Lelis da:Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Inst Canc Estado Sao Paulo,Ctr Invest Translac On, Ave Dr Arnaldo 251, BR-01246000 Sao Paulo, SP, Brazil
hcfmusp.description.articlenumber14482
hcfmusp.description.volume9
hcfmusp.origemWOS
hcfmusp.origem.idWOS:000489243200014
hcfmusp.origem.id2-s2.0-85073120847
hcfmusp.publisher.cityLONDONeng
hcfmusp.publisher.countryENGLANDeng
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dc.description.indexMEDLINEeng
hcfmusp.citation.scopus15-
hcfmusp.scopus.lastupdate2022-05-06-
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Instituto do Câncer do Estado de São Paulo - HC/ICESP

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