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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorHILL, Sarah C.
dc.contributor.authorVASCONCELOS, Jocelyne
dc.contributor.authorNETO, Zoraima
dc.contributor.authorJANDONDO, Domingos
dc.contributor.authorZE-ZE, Libia
dc.contributor.authorAGUIAR, Renato Santana
dc.contributor.authorXAVIER, Joilson
dc.contributor.authorTHEZE, Julien
dc.contributor.authorMIRANDELA, Marinela
dc.contributor.authorCANDIDO, Ana Luisa Micolo
dc.contributor.authorVAZ, Filipa
dc.contributor.authorSEBASTIAO, Cruz dos Santos
dc.contributor.authorWU, Chieh-Hsi
dc.contributor.authorKRAEMER, Moritz U. G.
dc.contributor.authorMELO, Adriana
dc.contributor.authorSCHAMBER-REIS, Bruno L. F.
dc.contributor.authorAZEVEDO, Girlene S. de
dc.contributor.authorTANURI, Amilcar
dc.contributor.authorHIGA, Luiza M.
dc.contributor.authorCLEMENTE, Carina
dc.contributor.authorSILVA, Sara Pereira da
dc.contributor.authorCANDIDO, Darlan da Silva
dc.contributor.authorCLARO, Ingra M.
dc.contributor.authorQUIBUCO, Domingos
dc.contributor.authorDOMINGOS, Cristovao
dc.contributor.authorPOCONGO, Barbara
dc.contributor.authorWATTS, Alexander G.
dc.contributor.authorKHAN, Kamran
dc.contributor.authorALCANTARA, Luiz Carlos Junior
dc.contributor.authorSABINO, Ester C.
dc.contributor.authorLACKRITZ, Eve
dc.contributor.authorPYBUS, Oliver G.
dc.contributor.authorALVES, Maria-Joao
dc.contributor.authorAFONSO, Joana
dc.contributor.authorFARIA, Nuno R.
dc.date.accessioned2019-11-06T18:47:40Z-
dc.date.available2019-11-06T18:47:40Z-
dc.date.issued2019
dc.identifier.citationLANCET INFECTIOUS DISEASES, v.19, n.10, p.1138-1147, 2019
dc.identifier.issn1473-3099
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/34016-
dc.description.abstractBackground Zika virus infections and suspected microcephaly cases have been reported in Angola since late 2016, but no data are available about the origins, epidemiology, and diversity of the virus. We aimed to investigate the emergence and circulation of Zika virus in Angola. Methods Diagnostic samples collected by the Angolan Ministry of Health as part of routine arboviral surveillance were tested by real-time reverse transcription PCR by the Instituto Nacional de Investigacao em Saude (Ministry of Health, Luanda, Angola). To identify further samples positive for Zika virus and appropriate for genomic sequencing, we also tested samples from a 2017 study of people with HIV in Luanda. Portable sequencing was used to generate Angolan Zika virus genome sequences from three people positive for Zika virus infection by real-time reverse transcription PCR, including one neonate with microcephaly. Genetic and mobility data were analysed to investigate the date of introduction and geographical origin of Zika virus in Angola. Brain CT and MRI, and serological assays were done on a child with microcephaly to confirm microcephaly and assess previous Zika virus infection. Findings Serum samples from 54 people with suspected acute Zika virus infection, 76 infants with suspected microcephaly, 24 mothers of infants with suspected microcephaly, 336 patients with suspected dengue virus or chikungunya virus infection, and 349 samples from the HIV study were tested by real-time reverse transcription PCR. Four cases identified between December, 2016, and June, 2017, tested positive for Zika virus. Analyses of viral genomic and human mobility data suggest that Zika virus was probably introduced to Angola from Brazil between July, 2015, and June, 2016. This introduction probably initiated local circulation of Zika virus in Angola that continued until at least June, 2017. The infant with microcephaly in whom CT and MRI were done had brain abnormalities consistent with congenital Zika syndrome and serological evidence for Zika virus infection. Interpretation Our analyses show that autochthonous transmission of the Asian lineage of Zika virus has taken place in Africa. Zika virus surveillance and surveillance of associated cases of microcephaly throughout the continent is crucial.eng
dc.description.sponsorshipSir Henry Dale Fellowship [204311/Z/16/Z]
dc.description.sponsorshipinternal Higher Education Funding Council for England Global Challenges Research Fund [005073]
dc.description.sponsorshipAfrica Oxford Initiative [AfiOx-48, AfiOx-60]
dc.description.sponsorshipJohn Fell Research Fund [005166]
dc.description.sponsorshipMedical Research CouncilMedical Research Council UK (MRC) [MR/S0195/1, 2018/14389-0]
dc.description.sponsorshipO Conselho Nacional de Desenvolvimento Cientifico e TecnologicoNational Council for Scientific and Technological Development (CNPq) [440900/2016-6, 440685/2016-8]
dc.description.sponsorshipFundacao Coordenacao de Aperfeicoamento de Pessoal de Nivel SuperiorCAPES [88881.130757/2016-01, 88887.130716/2016-00, 88881.130728/2016-01]
dc.description.sponsorshipEuropean Research CouncilEuropean Research Council (ERC) [614725-PATHPHYLODYN]
dc.description.sponsorshipOxford Martin School
dc.description.sponsorshipUK Medical Research CouncilMedical Research Council UK (MRC)
dc.description.sponsorshipCancer Research UKCancer Research UK [ANR00310]
dc.language.isoeng
dc.publisherELSEVIER SCI LTDeng
dc.relation.ispartofLancet Infectious Diseases
dc.rightsopenAccesseng
dc.subject.othertransmissioneng
dc.subject.otherafricaeng
dc.titleEmergence of the Asian lineage of Zika virus in Angola: an outbreak investigationeng
dc.typearticleeng
dc.rights.holderCopyright ELSEVIER SCI LTDeng
dc.identifier.doi10.1016/S1473-3099(19)30293-2
dc.identifier.pmid31559967
dc.subject.wosInfectious Diseaseseng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
hcfmusp.author.externalHILL, Sarah C.:Univ Oxford, Dept Zool, Oxford OX1 3PS, England
hcfmusp.author.externalVASCONCELOS, Jocelyne:Minist Hlth, Inst Nacl Invest Saude, Luanda, Angola
hcfmusp.author.externalNETO, Zoraima:Minist Hlth, Inst Nacl Invest Saude, Luanda, Angola
hcfmusp.author.externalJANDONDO, Domingos:Minist Hlth, Inst Nacl Invest Saude, Luanda, Angola
hcfmusp.author.externalZE-ZE, Libia:Inst Nacl Saude Doutor Ricardo Jorge, Aguas De Moura, Portugal; Univ Lisbon, Fac Sci, BioISI Biosyst & Integrat Sci Inst, Lisbon, Portugal
hcfmusp.author.externalAGUIAR, Renato Santana:Univ Fed Rio de Janeiro, Inst Biol, Dept Genet, Rio De Janeiro, Brazil; Univ Fed Minas Gerais, Dept Genet Ecol & Evolucao, Inst Ciencias Biol, Belo Horizonte, MG, Brazil
hcfmusp.author.externalXAVIER, Joilson:Univ Fed Minas Gerais, Dept Genet Ecol & Evolucao, Inst Ciencias Biol, Belo Horizonte, MG, Brazil
hcfmusp.author.externalTHEZE, Julien:Univ Oxford, Dept Zool, Oxford OX1 3PS, England
hcfmusp.author.externalMIRANDELA, Marinela:Minist Hlth, Inst Nacl Invest Saude, Luanda, Angola
hcfmusp.author.externalCANDIDO, Ana Luisa Micolo:Minist Hlth, Inst Nacl Invest Saude, Luanda, Angola
hcfmusp.author.externalVAZ, Filipa:Minist Hlth, Inst Nacl Invest Saude, Luanda, Angola
hcfmusp.author.externalSEBASTIAO, Cruz dos Santos:Minist Hlth, Inst Nacl Invest Saude, Luanda, Angola; Univ Agostinho Neto, Inst Super Ciencias Saude, Luanda, Angola
hcfmusp.author.externalWU, Chieh-Hsi:Univ Oxford, Dept Stat, Oxford, England
hcfmusp.author.externalKRAEMER, Moritz U. G.:Univ Oxford, Dept Zool, Oxford OX1 3PS, England; Boston Childrens Hosp, Computat Epidemiol Lab, Boston, MA USA; Harvard Med Sch, Boston, MA 02115 USA
hcfmusp.author.externalMELO, Adriana:Inst Pesquisa Prof Joaquim Amorim Neto, Campina Grande, Brazil
hcfmusp.author.externalSCHAMBER-REIS, Bruno L. F.:Ctr Univ Unifacisa, Dept Human Genet, Campina Grande, Brazil
hcfmusp.author.externalAZEVEDO, Girlene S. de:Inst Pesquisa Prof Joaquim Amorim Neto, Campina Grande, Brazil
hcfmusp.author.externalTANURI, Amilcar:Univ Fed Rio de Janeiro, Inst Biol, Dept Genet, Rio De Janeiro, Brazil
hcfmusp.author.externalHIGA, Luiza M.:Univ Fed Rio de Janeiro, Inst Biol, Dept Genet, Rio De Janeiro, Brazil
hcfmusp.author.externalCLEMENTE, Carina:Cligest Clin, Luanda, Angola
hcfmusp.author.externalSILVA, Sara Pereira da:Cligest Clin, Luanda, Angola
hcfmusp.author.externalCANDIDO, Darlan da Silva:Univ Oxford, Dept Zool, Oxford OX1 3PS, England
hcfmusp.author.externalQUIBUCO, Domingos:Hosp Pediat David Bernardino, Luanda, Angola
hcfmusp.author.externalDOMINGOS, Cristovao:Inst Nacl Luta SIDA, Luanda, Angola
hcfmusp.author.externalPOCONGO, Barbara:Inst Nacl Luta SIDA, Luanda, Angola
hcfmusp.author.externalWATTS, Alexander G.:St Michaels Hosp, Li Ka Shing Knowledge Inst, Toronto, ON, Canada; BlueDot, Toronto, ON, Canada
hcfmusp.author.externalKHAN, Kamran:St Michaels Hosp, Li Ka Shing Knowledge Inst, Toronto, ON, Canada; BlueDot, Toronto, ON, Canada; Univ Toronto, Dept Med, Toronto, ON, Canada
hcfmusp.author.externalALCANTARA, Luiz Carlos Junior:Univ Fed Minas Gerais, Dept Genet Ecol & Evolucao, Inst Ciencias Biol, Belo Horizonte, MG, Brazil; IOC Fundacao Oswaldo Cruz MS, Lab Flavivirus, Rio De Janeiro, Brazil
hcfmusp.author.externalLACKRITZ, Eve:WHO, Geneva, Switzerland
hcfmusp.author.externalPYBUS, Oliver G.:Univ Oxford, Dept Zool, Oxford OX1 3PS, England
hcfmusp.author.externalALVES, Maria-Joao:Inst Nacl Saude Doutor Ricardo Jorge, Aguas De Moura, Portugal
hcfmusp.author.externalAFONSO, Joana:Minist Hlth, Inst Nacl Invest Saude, Luanda, Angola
hcfmusp.author.externalFARIA, Nuno R.:Univ Oxford, Dept Zool, Oxford OX1 3PS, England
hcfmusp.description.beginpage1138
hcfmusp.description.endpage1147
hcfmusp.description.issue10
hcfmusp.description.volume19
hcfmusp.origemWOS
hcfmusp.origem.idWOS:000487824300040
hcfmusp.origem.id2-s2.0-85072536686
hcfmusp.publisher.cityOXFORDeng
hcfmusp.publisher.countryENGLANDeng
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dc.description.indexMEDLINEeng
dc.identifier.eissn1474-4457
hcfmusp.citation.scopus42-
hcfmusp.scopus.lastupdate2022-09-23-
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