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https://observatorio.fm.usp.br/handle/OPI/34047
Título: | Interleaving Stimulation in Parkinson Disease: Interesting to Whom? |
Autor: | FRANCA, Carina; BARBOSA, Egberto Reis; IGLESIO, Ricardo; TEIXEIRA, Manoel Jacobsen; CURY, Rubens Gisbert |
Citación: | WORLD NEUROSURGERY, v.130, p.E786-E793, 2019 |
Resumen: | BACKGROUND: Interleaving stimulation (ILS) is a stim-ulation strategy that can help the physician manage more challenging cases of patients with deep brain stimulation (DBS) for Parkinson disease (PD). It consists of altering 2 different programs on the electrode with the same frequency. OBJECTIVES: Our objective was to overview our patients experience with ILS and explore clinical scenarios in which ILS should be considered when programming DBS in patients with PD. METHODS: We retrospectively reviewed medical charts from 120 patients with PD treated with DBS between 2011 and 2018. RESULTS: Eighteen patients received ILS. One was excluded because of the medical chart was incomplete. The remaining 17 patients had subthalamic nucleus DBS (n = 14) and globus pallidus internus DBS (n = 3). Eight patients (47%) received ILS to improve rigidity and bradykinesia, 4 to improve dyskinesias, 4 because of refractory tremor, and 1 for gait management. Until the end of data collection, 13 of 17 patients (70%) were still on ILS, with a mean duration time of 28.8 months (range, 2-44 months) Four patients reported no benefit from ILS and had their program changed. CONCLUSIONS: Overall, ILS is useful 1) to use 2 contacts optimally improve 2 specific symptoms but have different therapeutic windows; 2) to avoid side effects related to current spreading to nearby areas; 3) to increase frequency in a small region; or 4) to stimulate a larger target area. |
Aparece en las colecciones: | Artigos e Materiais de Revistas Científicas - FM/MNE Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - HC/IPq Artigos e Materiais de Revistas Científicas - LIM/26 Artigos e Materiais de Revistas Científicas - LIM/45 |
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art_FRANCA_Interleaving_Stimulation_in_Parkinson_Disease_Interesting_to_Whom_2019.PDF Restricted Access | publishedVersion (English) | 613.73 kB | Adobe PDF | Visualizar/Abrir Request a copy |
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