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Title: Maternal supplementation with a synbiotic has distinct outcomes on offspring gut microbiota formation in A/J and C57BL/6 mice, differentially affecting airway inflammatory cell infiltration and mucus production
Authors: FUKUMORI, ClaudioCASARO, Mateus B.THOMAS, Andrew M.MENDES, EduardoRIBEIRO, Willian R.CRISMA, Amanda R.MURATA, Gilson M.BIZZARRO, BrunaDIAS-NETO, EmmanuelSETUBAL, Joao C.OLIVEIRA, Maria A.TAVARES-DE-LIMA, WothanCURI, RuiBORDIN, SilvanaSARTORELLI, PatriciaFERREIRA, Caroline M.
Citation: JOURNAL OF FUNCTIONAL FOODS, v.61, article ID 103496, 10p, 2019
Abstract: Emerging evidence has shown that the maternal diet influences the microbiota. Our objective was to elucidate whether synbiotic consumption during the perinatal period equally modulates offspring gut microbiota in the A/J and C57BL/6 and affects airway inflammatory cell infiltration. We administered the synbiotic to the dam throughout the whole perinatal period. To analyze the influence of gut microbiota changes on offspring health, we induced allergic airway inflammation on offspring. Twenty-four hours after the last ovalbumin challenge, pulmonary inflammation was analyzed. Perinatal synbiotic supplementation reduced eosinophilic inflammation and mucus production only in the C57BL/6 offspring. Synbiotic supplementation during the perinatal period increased the Lactobacillus genera, which could be associated with the immune regulatory effects observed in the C57BL/6 offspring. Interestingly, synbiotic supplementation increased the diversity of gut microbiota in the A/J offspring without improving airway inflammation, indicating that diversity itself was not sufficient to regulate experimental lung inflammation.
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Artigos e Materiais de Revistas Científicas - FM/Outros
Outros departamentos - FM/Outros

Artigos e Materiais de Revistas Científicas - LIM/27
LIM/27 - Laboratório de Neurociências

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