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https://observatorio.fm.usp.br/handle/OPI/34126
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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | |
dc.contributor.author | FUKUMORI, Claudio | |
dc.contributor.author | CASARO, Mateus B. | |
dc.contributor.author | THOMAS, Andrew M. | |
dc.contributor.author | MENDES, Eduardo | |
dc.contributor.author | RIBEIRO, Willian R. | |
dc.contributor.author | CRISMA, Amanda R. | |
dc.contributor.author | MURATA, Gilson M. | |
dc.contributor.author | BIZZARRO, Bruna | |
dc.contributor.author | DIAS-NETO, Emmanuel | |
dc.contributor.author | SETUBAL, Joao C. | |
dc.contributor.author | OLIVEIRA, Maria A. | |
dc.contributor.author | TAVARES-DE-LIMA, Wothan | |
dc.contributor.author | CURI, Rui | |
dc.contributor.author | BORDIN, Silvana | |
dc.contributor.author | SARTORELLI, Patricia | |
dc.contributor.author | FERREIRA, Caroline M. | |
dc.date.accessioned | 2019-11-06T18:50:28Z | - |
dc.date.available | 2019-11-06T18:50:28Z | - |
dc.date.issued | 2019 | |
dc.identifier.citation | JOURNAL OF FUNCTIONAL FOODS, v.61, article ID 103496, 10p, 2019 | |
dc.identifier.issn | 1756-4646 | |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/34126 | - |
dc.description.abstract | Emerging evidence has shown that the maternal diet influences the microbiota. Our objective was to elucidate whether synbiotic consumption during the perinatal period equally modulates offspring gut microbiota in the A/J and C57BL/6 and affects airway inflammatory cell infiltration. We administered the synbiotic to the dam throughout the whole perinatal period. To analyze the influence of gut microbiota changes on offspring health, we induced allergic airway inflammation on offspring. Twenty-four hours after the last ovalbumin challenge, pulmonary inflammation was analyzed. Perinatal synbiotic supplementation reduced eosinophilic inflammation and mucus production only in the C57BL/6 offspring. Synbiotic supplementation during the perinatal period increased the Lactobacillus genera, which could be associated with the immune regulatory effects observed in the C57BL/6 offspring. Interestingly, synbiotic supplementation increased the diversity of gut microbiota in the A/J offspring without improving airway inflammation, indicating that diversity itself was not sufficient to regulate experimental lung inflammation. | eng |
dc.description.sponsorship | Sao Paulo Research Foundation (FAPESP)Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2012/50410-8, 2016/13496-2] | |
dc.description.sponsorship | CAPES Brazilian Federal Agency for Support and Evaluation of Graduate Education within the Ministry of Education of BrazilCAPES | |
dc.language.iso | eng | |
dc.publisher | ELSEVIER | eng |
dc.relation.ispartof | Journal of Functional Foods | |
dc.rights | restrictedAccess | eng |
dc.subject | Lung inflammation | eng |
dc.subject | Perinatal | eng |
dc.subject | Synbiotic | eng |
dc.subject | Microbiota | eng |
dc.subject | Offspring | eng |
dc.subject | Genetic | eng |
dc.subject.other | asthma | eng |
dc.subject.other | disease | eng |
dc.subject.other | atopy | eng |
dc.subject.other | diet | eng |
dc.subject.other | hyperresponsiveness | eng |
dc.subject.other | prevention | eng |
dc.subject.other | resolution | eng |
dc.subject.other | anti-il-5 | eng |
dc.subject.other | pregnancy | eng |
dc.subject.other | dextrin | eng |
dc.title | Maternal supplementation with a synbiotic has distinct outcomes on offspring gut microbiota formation in A/J and C57BL/6 mice, differentially affecting airway inflammatory cell infiltration and mucus production | eng |
dc.type | article | eng |
dc.rights.holder | Copyright ELSEVIER | eng |
dc.identifier.doi | 10.1016/j.jff.2019.103496 | |
dc.subject.wos | Food Science & Technology | eng |
dc.subject.wos | Nutrition & Dietetics | eng |
dc.type.category | original article | eng |
dc.type.version | publishedVersion | eng |
hcfmusp.author.external | FUKUMORI, Claudio:Univ Fed Sao Paulo, Inst Environm Chem & Pharmaceut Sci, Dept Pharmaceut Sci, R Sao Nicolau 210, BR-0991303 Diadema, SP, Brazil | |
hcfmusp.author.external | CASARO, Mateus B.:Univ Fed Sao Paulo, Inst Environm Chem & Pharmaceut Sci, Dept Pharmaceut Sci, R Sao Nicolau 210, BR-0991303 Diadema, SP, Brazil | |
hcfmusp.author.external | THOMAS, Andrew M.:CIPE AC Camargo Canc Ctr, Med Genom Lab, Sao Paulo, Brazil; Univ Sao Paulo, Inst Chem, Dept Biochem, Sao Paulo, Brazil; Univ Sao Paulo, Bioinformat Grad Program, Sao Paulo, Brazil | |
hcfmusp.author.external | MENDES, Eduardo:Univ Fed Sao Paulo, Inst Environm Chem & Pharmaceut Sci, Dept Pharmaceut Sci, R Sao Nicolau 210, BR-0991303 Diadema, SP, Brazil | |
hcfmusp.author.external | RIBEIRO, Willian R.:Univ Fed Sao Paulo, Inst Environm Chem & Pharmaceut Sci, Dept Pharmaceut Sci, R Sao Nicolau 210, BR-0991303 Diadema, SP, Brazil | |
hcfmusp.author.external | CRISMA, Amanda R.:Univ Sao Paulo, Inst Biomed Sci 1, Dept Physiol & Biophys, Sao Paulo, Brazil | |
hcfmusp.author.external | MURATA, Gilson M.:Univ Sao Paulo, Inst Biomed Sci 1, Dept Physiol & Biophys, Sao Paulo, Brazil | |
hcfmusp.author.external | BIZZARRO, Bruna:Univ Sao Paulo, Inst Biomed Sci 4, Dept Immunol, Sao Paulo, Brazil | |
hcfmusp.author.external | SETUBAL, Joao C.:Univ Sao Paulo, Inst Chem, Dept Biochem, Sao Paulo, Brazil | |
hcfmusp.author.external | OLIVEIRA, Maria A.:Univ Sao Paulo, Inst Biomed Sci 1, Dept Pharmacol, Sao Paulo, Brazil | |
hcfmusp.author.external | TAVARES-DE-LIMA, Wothan:Univ Sao Paulo, Inst Biomed Sci 1, Dept Pharmacol, Sao Paulo, Brazil | |
hcfmusp.author.external | CURI, Rui:Univ Sao Paulo, Inst Biomed Sci 1, Dept Physiol & Biophys, Sao Paulo, Brazil; Cruzeiro do Sul Univ, Interdisciplinary Postgrad Program Hlth Sci, Sao Paulo, Brazil | |
hcfmusp.author.external | BORDIN, Silvana:Univ Sao Paulo, Inst Biomed Sci 1, Dept Physiol & Biophys, Sao Paulo, Brazil | |
hcfmusp.author.external | SARTORELLI, Patricia:Univ Fed Sao Paulo, Inst Environm Chem & Pharmaceut Sci, Dept Chem, Diadema, SP, Brazil | |
hcfmusp.author.external | FERREIRA, Caroline M.:Univ Fed Sao Paulo, Inst Environm Chem & Pharmaceut Sci, Dept Pharmaceut Sci, R Sao Nicolau 210, BR-0991303 Diadema, SP, Brazil | |
hcfmusp.description.articlenumber | 103496 | |
hcfmusp.description.volume | 61 | |
hcfmusp.origem | WOS | |
hcfmusp.origem.id | WOS:000485205700032 | |
hcfmusp.origem.id | 2-s2.0-85070527032 | |
hcfmusp.publisher.city | AMSTERDAM | eng |
hcfmusp.publisher.country | NETHERLANDS | eng |
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dc.description.index | PubMed | eng |
hcfmusp.citation.scopus | 4 | - |
hcfmusp.scopus.lastupdate | 2024-03-29 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/Outros Artigos e Materiais de Revistas Científicas - LIM/27 |
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