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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | |
dc.contributor.author | LO-KIOENG-SHIOE, Mallory S. | |
dc.contributor.author | VAVERE, Andrea L. | |
dc.contributor.author | ARBAB-ZADEH, Armin | |
dc.contributor.author | SCHUIJF, Joanne D. | |
dc.contributor.author | ROCHITTE, Carlos E. | |
dc.contributor.author | CHEN, Marcus Y. | |
dc.contributor.author | RIEF, Matthias | |
dc.contributor.author | KOFOED, Klaus F. | |
dc.contributor.author | CLOUSE, Melvin E. | |
dc.contributor.author | SCHOLTE, Arthur J. | |
dc.contributor.author | MILLER, Julie M. | |
dc.contributor.author | BETOKO, Aisha | |
dc.contributor.author | BLAHA, Michael J. | |
dc.contributor.author | COX, Christopher | |
dc.contributor.author | DECKERS, Jaap W. | |
dc.contributor.author | LIMA, Joao A. C. | |
dc.date.accessioned | 2019-11-06T18:52:25Z | - |
dc.date.available | 2019-11-06T18:52:25Z | - |
dc.date.issued | 2019 | |
dc.identifier.citation | JOURNAL OF THE AMERICAN HEART ASSOCIATION, v.8, n.6, article ID e007201, 9p, 2019 | |
dc.identifier.issn | 2047-9980 | |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/34188 | - |
dc.description.abstract | Background-The predictive value of coronary artery calcium (CAC) has been widely studied; however, little is known about specific characteristics of CAC that are most predictive. We aimed to determine the independent associations of Agatston score, CAC volume, CAC area, CAC mass, and CAC density score with major adverse cardiac events in patients with suspected coronary artery disease. Methods and Results-A total of 379 symptomatic participants, aged 45 to 85 years, referred for invasive coronary angiography, who underwent coronary calcium scanning and computed tomography angiography as part of the CORE320 (Combined Noninvasive Coronary Angiography and Myocardial Perfusion Imaging Using 320 Detector Computed Tomography) study, were included. Agatston score, CAC volume, area, mass, and density were computed on noncontrast images. Stenosis measurements were made on contrast-enhanced images. The primary outcome of 2-year major adverse cardiac events (30 revascularizations [>182 days of index catheterization], 5 myocardial infarctions, 1 cardiac death, 9 hospitalizations, and 1 arrhythmia) occurred in 32 patients (8.4%). Associations were estimated using multivariable proportional means models. Median age was 62 (interquartile range, 56-68) years, 34% were women, and 56% were white. In separate models, the Agatston, volume, and density scores were all significantly associated with higher risk of major adverse cardiac events after adjustment for age, sex, race, and statin use; density was the strongest predictor in all CAC models. CAC density did not provide incremental value over Agatston score after adjustment for diameter stenosis, age, sex, and race. Conclusions-In symptomatic patients, CAC density was the strongest independent predictor of major adverse cardiac events among CAC scores, but it did not provide incremental value beyond the Agatston score after adjustment for diameter stenosis. | eng |
dc.description.sponsorship | Toshiba Medical Systems | |
dc.language.iso | eng | |
dc.publisher | WILEY | eng |
dc.relation.ispartof | Journal of the American Heart Association | |
dc.rights | openAccess | eng |
dc.subject | calcium density | eng |
dc.subject | cardiac computed tomography | eng |
dc.subject | coronary artery calcium | eng |
dc.subject | coronary artery disease | eng |
dc.subject | prognosis | eng |
dc.subject.other | artery calcium | eng |
dc.subject.other | prognostic value | eng |
dc.subject.other | ct angiography | eng |
dc.subject.other | computed-tomography | eng |
dc.subject.other | diagnostic performance | eng |
dc.subject.other | cardiovascular-disease | eng |
dc.subject.other | risk markers | eng |
dc.subject.other | calcification | eng |
dc.subject.other | atherosclerosis | eng |
dc.subject.other | score | eng |
dc.title | Coronary Calcium Characteristics as Predictors of Major Adverse Cardiac Events in Symptomatic Patients: Insights From the CORE320 Multinational Study | eng |
dc.type | article | eng |
dc.rights.holder | Copyright WILEY | eng |
dc.identifier.doi | 10.1161/JAHA.117.007201 | |
dc.identifier.pmid | 30879377 | |
dc.subject.wos | Cardiac & Cardiovascular Systems | eng |
dc.type.category | original article | eng |
dc.type.version | publishedVersion | eng |
hcfmusp.author.external | LO-KIOENG-SHIOE, Mallory S.:Johns Hopkins Hosp & Sch Med, Dept Cardiol, Baltimore, MD USA; Erasmus Univ, Erasmus Med Ctr, Dept Cardiol, Rotterdam, Netherlands | |
hcfmusp.author.external | VAVERE, Andrea L.:Johns Hopkins Hosp & Sch Med, Dept Cardiol, Baltimore, MD USA | |
hcfmusp.author.external | ARBAB-ZADEH, Armin:Johns Hopkins Hosp & Sch Med, Dept Cardiol, Baltimore, MD USA | |
hcfmusp.author.external | SCHUIJF, Joanne D.:Toshiba Med Syst Europe BV, Zoetermeer, Netherlands | |
hcfmusp.author.external | CHEN, Marcus Y.:NHLBI, NIH, Bldg 10, Bethesda, MD 20892 USA | |
hcfmusp.author.external | RIEF, Matthias:Charite, Dept Radiol, Berlin, Germany | |
hcfmusp.author.external | KOFOED, Klaus F.:Univ Copenhagen, Heart Ctr, Dept Cardiol, Copenhagen, Denmark | |
hcfmusp.author.external | CLOUSE, Melvin E.:Harvard Univ, Beth Israel Deaconess Med Ctr, Dept Cardiol, Boston, MA 02215 USA | |
hcfmusp.author.external | SCHOLTE, Arthur J.:Leiden Univ, Med Ctr, Dept Cardiol, Leiden, Netherlands | |
hcfmusp.author.external | MILLER, Julie M.:Johns Hopkins Hosp & Sch Med, Dept Cardiol, Baltimore, MD USA | |
hcfmusp.author.external | BETOKO, Aisha:Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA | |
hcfmusp.author.external | BLAHA, Michael J.:Johns Hopkins Hosp & Sch Med, Dept Cardiol, Baltimore, MD USA; Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA | |
hcfmusp.author.external | COX, Christopher:Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA | |
hcfmusp.author.external | DECKERS, Jaap W.:Erasmus Univ, Erasmus Med Ctr, Dept Cardiol, Rotterdam, Netherlands | |
hcfmusp.author.external | LIMA, Joao A. C.:Johns Hopkins Hosp & Sch Med, Dept Cardiol, Baltimore, MD USA | |
hcfmusp.description.articlenumber | e007201 | |
hcfmusp.description.issue | 6 | |
hcfmusp.description.volume | 8 | |
hcfmusp.origem | WOS | |
hcfmusp.origem.id | WOS:000484573500001 | |
hcfmusp.origem.id | 2-s2.0-85063276996 | |
hcfmusp.publisher.city | HOBOKEN | eng |
hcfmusp.publisher.country | USA | eng |
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dc.description.index | MEDLINE | eng |
hcfmusp.citation.scopus | 25 | - |
hcfmusp.scopus.lastupdate | 2024-03-29 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - HC/InCor Artigos e Materiais de Revistas Científicas - LIM/64 Artigos e Materiais de Revistas Científicas - ODS/03 |
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