Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/34653
Title: Transcranial Photobiomodulation with Near-Infrared Light for Generalized Anxiety Disorder: A Pilot Study
Authors: CARNEIRO, Ana Maria CostaPOIANI, Guilherme CruzZANINNOTO, Ana LuizaOSORIO, Rodrigo LazoOLIVEIRA, Marcelo de LimaPAIVA, Wellingson SilvaZANGARO, Renato Amaro
Citation: PHOTOBIOMODULATION PHOTOMEDICINE AND LASER SURGERY, v.37, n.10, p.657-666, 2019
Abstract: Objective: Our aim was to test the anxiolytic effect of transcranial photobiomodulation (t-PBM) with near-infrared light (NIR) in subjects suffering from generalized anxiety disorder (GAD). Background: t-PBM with NIR is an experimental, noninvasive treatment for mood and anxiety disorders. Preliminary evidence indicates a potential anxiolytic effect of transcranial NIR. Methods: Fifteen subjects suffering from GAD were recruited in an open-label 8-week study. Each participant self-administered t-PBM daily, for 20 min (continuous wave; 830 nm peak wavelength; average irradiance 30 mW/cm(2); average fluence 36 J/cm(2); total energy delivered per session 2.9 kJ: total output power 2.4 W) broadly on the forehead (total area 80 cm(2)) with an LED-cluster headband (Cerebral Sciences). Outcome measures were the reduction in total scores of the Hamilton Anxiety Scale (SIGH-A), the Clinical Global Impressions-Severity (CGI-S) subscale and the Pittsburgh Sleep Quality Index (PSQI) subscales from baseline to last observation carried forward. Results: Of the 15 recruited subjects (mean age 30 +/- 14 years; 67% women), 12 (80%) completed the open trial. Results show a significant reduction in the total scores of SIGH-A (from 17.27 +/- 4.89 to 8.47 +/- 4.87; p < 0.001; Cohen's d effect size = 1.47), in the CGI-S subscale (from 4.53 +/- 0.52 to 2.87 +/- 0.83; p < 0.001; Cohen's d effect size = 2.04), as well as significant improvements in sleep at the PSQI. t-PBM was well tolerated with no serious adverse events. Conclusions: Based on our pilot study, t-PBM with NIR is a promising alternative treatment for GAD. Larger, randomized, double-blind, sham-controlled studies are needed.
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