Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/35380
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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorMORENO, Marina L.
dc.contributor.authorGOERIGK, Stephan A.
dc.contributor.authorBERTOLA, Laiss
dc.contributor.authorSUEMOTO, Claudia K.
dc.contributor.authorRAZZA, Lais B.
dc.contributor.authorMOFFA, Adriano H.
dc.contributor.authorVERONEZI, Beatriz P.
dc.contributor.authorTORT, Luara
dc.contributor.authorNOGUEIRA, Barbara S.
dc.contributor.authorGATTAZ, Wagner F.
dc.contributor.authorFRAGUAS, Renerio
dc.contributor.authorPADBERG, Frank
dc.contributor.authorLOTUFO, Paulo A.
dc.contributor.authorBENSENOR, Isabela M.
dc.contributor.authorBRUNONI, Andre R.
dc.date.accessioned2020-03-24T14:45:12Z
dc.date.available2020-03-24T14:45:12Z
dc.date.issued2020
dc.identifier.citationJOURNAL OF AFFECTIVE DISORDERS, v.263, p.344-352, 2020
dc.identifier.issn0165-0327
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/35380
dc.description.abstractBackground: Cognitive deficits in major depressive disorder (MDD) are associated with low quality of life and higher suicide risk. Antidepressant drugs have modest to null effects in improving such deficits. Therefore, we investigated the cognitive effects of transcranial direct current stimulation (tDCS), which is a promising antidepressant non-pharmacological intervention, in MDD. Methods: An exploratory analysis on cognitive performance was conducted in 243 depressed patients from the Escitalopram vs. Electric Current Therapy for Treating Depression Clinical Study (ELECT-TDCS), a sham-controlled study comparing the efficacy of tDCS vs. escitalopram. A neuropsychological battery was applied at baseline and endpoint (10 weeks of treatment) to create composite cognitive scores (processing speed, working memory, and verbal fluency). Linear mixed regression models were used to evaluate changes according to intervention groups, adjusted for confounding variables (age, years of schooling, gender, and benzodiazepine use) and depression improvement. Results: No cognitive deterioration was observed in any group. Patients receiving tDCS presented reduced practice gains compared to placebo in processing speed. In patients receiving escitalopram vs. placebo and in the subgroup of clinical responders ( > 50% depression improvement from baseline), those receiving tDCS vs. placebo presented increased performance in verbal fluency. No significant differences between tDCS and escitalopram groups were detected. Limitations: Absence of healthy controls. Conclusion: Prefrontal tDCS did not lead to cognitive deficits in depressed patients, although it reduced practice effects in processing speed. tDCS responders presented increased performance in verbal fluency. Further investigation of tDCS cognitive effects in depression is warranted.eng
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2012/20911-5]
dc.description.sponsorshipNARSAD Young Investigator from the Brain & Behavior Research FoundationNARSAD [20493]
dc.description.sponsorship2013 FAPESP Young Researcher from the Sao Paulo State FoundationFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [20911-5]
dc.description.sponsorshipNational Council for Scientific and Technological Development (CNPq, PQ-1B)National Council for Scientific and Technological Development (CNPq)
dc.description.sponsorshipProgram of Academic Productivity (PIPA) of the University of Sao Paulo Medical School
dc.description.sponsorshipAssociacao Beneficente Alzira Denise Hertzog da Silva
dc.description.sponsorshipCAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior)CAPES
dc.language.isoeng
dc.publisherELSEVIEReng
dc.relation.ispartofJournal of Affective Disorders
dc.rightsrestrictedAccesseng
dc.subjectCognitioneng
dc.subjectTranscranial direct current stimulation (tDCS)eng
dc.subjectMajor depressive disordereng
dc.subjectDorsolateral prefrontal cortexeng
dc.subjectSafetyeng
dc.subjectPsychiatryeng
dc.subject.otherdirect-current stimulationeng
dc.subject.otherdorsolateral prefrontal cortexeng
dc.subject.othernoninvasive brain-stimulationeng
dc.subject.otherverbal fluencyeng
dc.subject.othercurrent therapyeng
dc.subject.otherbipolar depressioneng
dc.subject.othermetaanalysiseng
dc.subject.othersafetyeng
dc.subject.otherunipolareng
dc.subject.otheracceptabilityeng
dc.titleCognitive changes after tDCS and escitalopram treatment in major depressive disorder: Results from the placebo-controlled ELECT-TDCS trialeng
dc.typearticleeng
dc.rights.holderCopyright ELSEVIEReng
dc.identifier.doi10.1016/j.jad.2019.12.009
dc.identifier.pmid31969264
dc.subject.wosClinical Neurologyeng
dc.subject.wosPsychiatryeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
hcfmusp.author.externalGOERIGK, Stephan A.:Ludwig Maximilians Univ Munchen, Dept Psychiat & Psychotherapy, Munich, Germany; Ludwig Maximilians Univ Munchen, Dept Psychol Methodol & Assessment, Leopoldstr 13, D-80802 Munich, Germany; Univ Appl Sci, Hsch Fresenius, Infanteriestr 11A, D-80797 Munich, Germany
hcfmusp.author.externalMOFFA, Adriano H.:Univ Sao Paulo, Fac Med, Dept & Inst Psiquiatria, Sao Paulo, Brazil; Univ Sao Paulo, Lab Neurosci LIM27, Sao Paulo, Brazil; Univ Sao Paulo, Natl Inst Biomarkers Neuropsychiat, Sao Paulo, Brazil; Univ New South Wales, Sch Psychiat, Black Dog Inst, Sydney, NSW, Australia
hcfmusp.author.externalVERONEZI, Beatriz P.:Univ Sao Paulo, Dept Clin Med, Fac Med, Sao Paulo, Brazil; Univ Sao Paulo, Hosp Univ, Sao Paulo, Brazil
hcfmusp.author.externalNOGUEIRA, Barbara S.:Univ Sao Paulo, Dept Clin Med, Fac Med, Sao Paulo, Brazil; Univ Sao Paulo, Hosp Univ, Sao Paulo, Brazil
hcfmusp.author.externalPADBERG, Frank:Ludwig Maximilians Univ Munchen, Dept Psychiat & Psychotherapy, Munich, Germany
hcfmusp.description.beginpage344
hcfmusp.description.endpage352
hcfmusp.description.volume263
hcfmusp.origemWOS
hcfmusp.origem.idWOS:000508874400045
hcfmusp.origem.id2-s2.0-85076170930
hcfmusp.publisher.cityAMSTERDAMeng
hcfmusp.publisher.countryNETHERLANDSeng
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dc.description.indexMEDLINEeng
dc.identifier.eissn1573-2517
hcfmusp.citation.scopus16
hcfmusp.scopus.lastupdate2024-02-23-
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