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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorMARQUES, Ana Luiza Santos
dc.contributor.authorANDRES, Marina Paula
dc.contributor.authorKHO, Rosanne M.
dc.contributor.authorABRAO, Mauricio Simoes
dc.date.accessioned2020-03-24T14:50:18Z
dc.date.available2020-03-24T14:50:18Z
dc.date.issued2020
dc.identifier.citationJOURNAL OF MINIMALLY INVASIVE GYNECOLOGY, v.27, n.2, p.332-343, 2020
dc.identifier.issn1553-4650
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/35485
dc.description.abstractStudy Objective: To systematically review the literature regarding the efficacy of high-intensity focused ultrasound (HIFU) in reducing adenomyotic lesions, patients' pain and bleeding symptoms, and the impact on patients' quality of life. Data Source: A search was performed through PubMed/MEDLINE and Cochrane databases. Methods of Study Selection: All available studies published in the English language in the last 10 years that evaluated the effects of HIFU for adenomyosis. Tabulation, Integration, and Results: A systematic review was performed following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A meta-analysis was performed on data from homogeneous studies. Pooled results from the meta-analysis showed that after HIFU treatment for adenomyosis, a large effect was observed in reducing the uterine volume at 12 months (standard mean difference [SMD] = 0.85), a significant reduction in dysmenorrhea at 3 months (SMD = 1.83) and 12 months (SMD = 2.37), and a significant improvement in quality of life at 6 months (SMD = 3.0) and 12 months (SMD = 2.75). Adverse reactions after HIFU were reported in 55.9% of patients. Conclusion: This review suggests a potential benefit for HIFU in the treatment of adenomyosis-related symptoms; however, findings of the meta-analysis were based on fewer, nonuniform studies, which did not equally account for each specific symptom/parameter across the board. Results showed there appears to be a potential of HIFU in the treatment of adenomyosis-related symptoms. To date, there are no comparative and randomized clinical trials comparing the HIFU technique with other conservative treatment options. As yet, there are insufficient data regarding fertility and pregnancy outcomes.eng
dc.language.isoeng
dc.publisherELSEVIER SCIENCE INCeng
dc.relation.ispartofJournal of Minimally Invasive Gynecology
dc.rightsrestrictedAccesseng
dc.subjectHigh-intensity focused ultrasoundeng
dc.subjectAdenomyosiseng
dc.subjectSystematic revieweng
dc.subject.otheruterine adenomyosiseng
dc.subject.otherablationeng
dc.subject.otherinfertilityeng
dc.subject.othervalidationeng
dc.subject.otherfertilityeng
dc.subject.othertherapyeng
dc.subject.otherhifueng
dc.titleIs High-intensity Focused Ultrasound Effective for the Treatment of Adenomyosis? A Systematic Review and Meta-analysiseng
dc.typearticleeng
dc.rights.holderCopyright ELSEVIER SCIENCE INCeng
dc.identifier.doi10.1016/j.jmig.2019.07.029
dc.identifier.pmid31377454
dc.subject.wosObstetrics & Gynecologyeng
dc.type.categoryrevieweng
dc.type.versionpublishedVersioneng
hcfmusp.author.externalKHO, Rosanne M.:Cleveland Clin, Womens Hlth Inst, Benign Gynecol Surg Sect, Cleveland, OH 44106 USA
hcfmusp.description.beginpage332
hcfmusp.description.endpage343
hcfmusp.description.issue2
hcfmusp.description.volume27
hcfmusp.origemWOS
hcfmusp.origem.idWOS:000510638000021
hcfmusp.origem.id2-s2.0-85071855248
hcfmusp.publisher.cityNEW YORKeng
hcfmusp.publisher.countryUSAeng
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dc.description.indexMEDLINEeng
dc.identifier.eissn1553-4669
hcfmusp.citation.scopus34
hcfmusp.scopus.lastupdate2024-03-29-
Appears in Collections:

Artigos e Materiais de Revistas Científicas - FM/MOG
Departamento de Obstetrícia e Ginecologia - FM/MOG

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - LIM/58
LIM/58 - Laboratório de Ginecologia Estrutural e Molecular


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