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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorREIS-JUNIOR, Paulo
dc.contributor.authorTANIGAWA, Ryan
dc.contributor.authorMESQUITA, Gustavo Heluani Antunes de
dc.contributor.authorBASAN, Natalia
dc.contributor.authorALVES, Venancio
dc.contributor.authorD'ALBUQUERQUE, Luiz Augusto Carneiro
dc.contributor.authorANDRAUS, Wellington
dc.identifier.citationCLINICS, v.74, article ID e1070, 8p, 2019
dc.description.abstractOBJECTIVE: With the increasing prevalence of steatosis, the number of steatotic liver grafts from deceased donors is also increasing. Thus, determining the prevalence and the population risk factors of steatosis may assist in risk stratification. The aim of this study was to evaluate the prevalence and predictors of steatosis and steatohepatitis among livers from adults who died due to non-burn trauma. METHODS: Specimens were collected from 224 adults undergoing autopsy at a regional autopsy referral center from September 2011 to April 2013. Histopathological examination was performed on six samples obtained from different lobes of each liver. The outcomes of interest were the presence of steatosis, steatohepatitis, NASH inflammation and NASH fibrosis. The main predictors were body mass index, abdominal circumference, liver weight and volume, presence of cholelithiasis, and siderosis. Our modeling strategy made use of a series of generalized linear models with a binomial family. RESULTS: Our sample had a mean age of 40 years; steatosis was diagnosed in 48.2% of cases, and steatohepatitis was diagnosed in 2.7%. The presence of a high proportion of fatty changes was more prevalent among males and older individuals, with the most affected age group being 41-60 years. When evaluating the crude odds ratio for steatosis, the factors significantly associated with an increased risk of steatosis were greater abdominal circumference, BMI, and liver weight and the presence of siderosis. CONCLUSION: Our study reinforces the role of older age, obesity and hepatomegaly as predictors of fatty liver disease. These variables should be considered in the assessment of fatty changes in the livers of potential liver donors.eng
dc.subjectFatty Livereng
dc.subjectLiver Diseaseeng
dc.subject.otherfatty liver-diseaseeng
dc.subject.otherhepatic steatosiseng
dc.subject.othernonalcoholic steatohepatitiseng
dc.subject.otheroxidative stresseng
dc.titleSteatosis and steatohepatitis found in adults after death due to non-burn traumaeng
dc.rights.holderCopyright HOSPITAL CLINICAS, UNIV SAO PAULOeng
dc.subject.wosMedicine, General & Internaleng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng, Paulo:Univ Fed Tocantins, Fac Med, Palmas, TO, Brazil, Natalia:Univ Fed Tocantins, Fac Med, Palmas, TO, Brazil
hcfmusp.publisher.citySAO PAULOeng
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Appears in Collections:

Artigos e Materiais de Revistas Científicas - FM/MGT
Departamento de Gastroenterologia - FM/MGT

Artigos e Materiais de Revistas Científicas - FM/MPT
Departamento de Patologia - FM/MPT

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - LIM/14
LIM/14 - Laboratório de Investigação em Patologia Hepática

Artigos e Materiais de Revistas Científicas - LIM/37
LIM/37 - Laboratório de Transplante e Cirurgia de Fígado

Artigos e Materiais de Revistas Científicas - ODS/03
ODS/03 - Saúde e bem-estar

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