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https://observatorio.fm.usp.br/handle/OPI/35535
Title: | Levels of Polonium-210 in brain and pulmonary tissues: Preliminary study in autopsies conducted in the city of Sao Paulo, Brazil |
Authors: | SANTOS, Nathalia Villa dos; VIEIRA, Carolina Leticia Zilli; SALDIVA, Paulo Hilario Nascimento; MAZZILLI, Barbara Paci; SAIKI, Mitiko; SAUEIA, Catia Heloisa; ANDRE, Carmen Diva Saldiva De; JUSTO, Lisie Tocci; NISTI, Marcelo Bessa; KOUTRAKIS, Petros |
Citation: | SCIENTIFIC REPORTS, v.10, n.1, article ID 180, 7p, 2020 |
Abstract: | The accumulation of detectable amounts of radon progeny in human tissues may be a risk factor for development and progression of chronic diseases. In this preliminary study, we analyzed the levels of alpha-emitting radon progeny Polonium-210 (Po-210) in the olfactory epithelium, olfactory bulb, frontal lobe, and lung tissues in cadavers from the city of Sao Paulo, SP, Brazil. We also assessed the association between Po-210 levels and exposure parameters for urban air pollution using linear regression models adjusted for age, sex, smoke, time living in Sao Paulo, daily commuting, socioeconomic index, and anthracosis (traffic-related black carbon accumulation in the pleural region and in lymph). Our findings show that the concentration of Po-210 was associated with anthracosis in lungs of non-smokers (coefficient=6.0; standard error=2.9; p=0.04). Individuals with lower socioeconomic status also had significantly higher Po-210 levels in lungs (coefficient=-1.19; standard error=0.58; p=0.042). The olfactory bulb had higher Po-210 levels than either olfactory epithelium (p=0.071), frontal lobe (p<0.001), or lungs (p=0.037). Our findings of the deposition of Po-210 in autopsy tissues suggest that airborne radionuclides may contribute to the development of chronic diseases, including neurodegenerative diseases. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MPT Artigos e Materiais de Revistas Científicas - HC/InCor Artigos e Materiais de Revistas Científicas - LIM/05 Artigos e Materiais de Revistas Científicas - ODS/03 Artigos e Materiais de Revistas Científicas - ODS/11 |
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