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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | |
dc.contributor.author | FORESTO-NETO, Orestes | |
dc.contributor.author | ALBINO, Amanda Helen | |
dc.contributor.author | ARIAS, Simone Costa Alarcon | |
dc.contributor.author | FAUSTINO, Viviane Dias | |
dc.contributor.author | ZAMBOM, Fernanda Florencia Fregnan | |
dc.contributor.author | CENEDEZE, Marcos Antonio | |
dc.contributor.author | ELIAS, Rosilene Motta | |
dc.contributor.author | MALHEIROS, Denise Maria Avancini Costa | |
dc.contributor.author | CAMARA, Niels Olsen Saraiva | |
dc.contributor.author | FUJIHARA, Clarice Kazue | |
dc.contributor.author | ZATZ, Roberto | |
dc.date.accessioned | 2020-03-24T15:00:29Z | |
dc.date.available | 2020-03-24T15:00:29Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | FRONTIERS IN PHYSIOLOGY, v.11, article ID 84, 11p, 2020 | |
dc.identifier.issn | 1664-042X | |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/35706 | |
dc.description.abstract | High glucose concentration can activate TLR4 and NF-kappa B, triggering the production of proinflammatory mediators. We investigated whether the NF-kappa B pathway is involved in the pathogenesis and progression of experimental diabetic kidney disease (DKD) in a model of long-term type 1 diabetes mellitus (DM). Adult male Munich-Wistar rats underwent DM by a single streptozotocin injection, and were kept moderately hyperglycemic by daily insulin injections. After 12 months, two subgroups - progressors and non-progressors - could be formed based on the degree of glomerulosclerosis. Only progressors exhibited renal TLR4, NF-kappa B and IL-6 activation. This scenario was already present in rats with short-term DM (2 months), at a time when no overt glomerulosclerosis can be detected. Chronic treatment with the NF-kappa B inhibitor, pyrrolidine dithiocarbamate (PDTC), prevented activation of renal TLR4, NF-kappa B or IL-6, without interfering with blood glucose. PDTC prevented the development of glomerular injury/inflammation and oxidative stress in DM rats. In addition, the NF-kappa B p65 component was detected in sclerotic glomeruli and inflamed interstitial areas in biopsy material from patients with type 1 DM. These observations indicate that the renal NF-kappa B pathway plays a key role in the development and progression of experimental DKD, and can become an important therapeutic target in the quest to prevent the progression of human DKD. | eng |
dc.description.sponsorship | Sao Paulo Research Foundation (FAPESP)Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2012/10926-5, 2013/12256-0] | |
dc.description.sponsorship | National Council for Scientific and Technological Development (CNPq) awardNational Council for Scientific and Technological Development (CNPq) [303684/2013-5] | |
dc.language.iso | eng | |
dc.publisher | FRONTIERS MEDIA SA | eng |
dc.relation.ispartof | Frontiers in Physiology | |
dc.rights | openAccess | eng |
dc.subject | diabetic kidney disease | eng |
dc.subject | glomerulosclerosis | eng |
dc.subject | NF-kappa B | eng |
dc.subject | innate immunity | eng |
dc.subject | pyrrolidine dithiocarbamate | eng |
dc.subject.other | glycation end-products | eng |
dc.subject.other | mesangial cells | eng |
dc.subject.other | receptor | eng |
dc.subject.other | expression | eng |
dc.subject.other | inflammation | eng |
dc.subject.other | nephropathy | eng |
dc.subject.other | inhibition | eng |
dc.subject.other | prevention | eng |
dc.subject.other | pathways | eng |
dc.title | NF-kappa B System Is Chronically Activated and Promotes Glomerular Injury in Experimental Type 1 Diabetic Kidney Disease | eng |
dc.type | article | eng |
dc.rights.holder | Copyright FRONTIERS MEDIA SA | eng |
dc.identifier.doi | 10.3389/fphys.2020.00084 | |
dc.identifier.pmid | 32116790 | |
dc.subject.wos | Physiology | eng |
dc.type.category | original article | eng |
dc.type.version | publishedVersion | eng |
hcfmusp.author.external | CENEDEZE, Marcos Antonio:Univ Fed Sao Paulo, Div Nephrol, Dept Med, Sao Paulo, Brazil | |
hcfmusp.description.articlenumber | 84 | |
hcfmusp.description.volume | 11 | |
hcfmusp.origem | WOS | |
hcfmusp.origem.id | WOS:000517454600001 | |
hcfmusp.origem.id | 2-s2.0-85081110559 | |
hcfmusp.publisher.city | LAUSANNE | eng |
hcfmusp.publisher.country | SWITZERLAND | eng |
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dc.description.index | PubMed | eng |
hcfmusp.citation.scopus | 27 | |
hcfmusp.scopus.lastupdate | 2024-03-29 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MCM Artigos e Materiais de Revistas Científicas - FM/MPT Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/05 Artigos e Materiais de Revistas Científicas - LIM/16 Artigos e Materiais de Revistas Científicas - ODS/03 |
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