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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | |
dc.contributor.author | FELIZARDO, Raphael J. F. | |
dc.contributor.author | ALMEIDA, Danilo C. de | |
dc.contributor.author | PEREIRA, Rafael L. | |
dc.contributor.author | WATANABE, Ingrid K. M. | |
dc.contributor.author | DOIMO, Nayara T. S. | |
dc.contributor.author | RIBEIRO, Willian R. | |
dc.contributor.author | CENEDEZE, Marcos A. | |
dc.contributor.author | HIYANE, Meire I. | |
dc.contributor.author | AMANO, Mariane T. | |
dc.contributor.author | BRAGA, Tarcio T. | |
dc.contributor.author | FERREIRA, Caroline M. | |
dc.contributor.author | PARMIGIANI, Raphael B. | |
dc.contributor.author | ANDRADE-OLIVEIRA, Vinicius | |
dc.contributor.author | VOLPINI, Rildo A. | |
dc.contributor.author | VINOLO, Marco Aurelio R. | |
dc.contributor.author | MARINO, Eliana | |
dc.contributor.author | ROBERT, Remy | |
dc.contributor.author | MACKAY, Charles R. | |
dc.contributor.author | CAMARA, Niels O. S. | |
dc.date.accessioned | 2020-03-24T15:00:30Z | |
dc.date.available | 2020-03-24T15:00:30Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | FASEB JOURNAL, v.33, n.11, p.11894-11908, 2019 | |
dc.identifier.issn | 0892-6638 | |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/35707 | |
dc.description.abstract | Butyrate is a short-chain fatty acid derived from the metabolism of indigestible carbohydrates by the gut microbiota. Butyrate contributes to gut homeostasis, but it may also control inflammatory responses and host physiology in other tissues. Butyrate inhibits histone deacetylases, thereby affecting gene transcription, and also signals through the metabolite-sensing G protein receptor (GPR)109a. We produced an mAb to mouse GPR109a and found high expression on podocytes in the kidney. Wild-type and Gpr109a(-/-) mice were induced to develop nephropathy by a single injection of Adriamycin and treated with sodium butyrate or high butyrate-releasing high-amylose maize starch diet. Butyrate improved proteinuria by preserving podocyte at glomerular basement membrane and attenuated glomerulosclerosis and tissue inflammation. This protective phenotype was associated with increased podocyte-related proteins and a normalized pattern of acetylation and methylation at promoter sites of genes essential for podocyte function. We found that GPR109a is expressed by podocytes, and the use of Gpr109a(-/-) mice showed that the protective effects of butyrate depended on GPR109a expression. A prebiotic diet that releases high amounts of butyrate also proved highly effective for protection against kidney disease. Butyrate and GPR109a play a role in the pathogenesis of kidney disease and provide one of the important molecular connections between diet, the gut microbiota, and kidney disease. | eng |
dc.description.sponsorship | Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2012/15205-4, 2012/50410-8, 2012/02270-2, 2014/13135-4, 2017/06222-06, 2017/05264-7] | |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Cientifico e Tecnologico, (CNPq)National Council for Scientific and Technological Development (CNPq) | |
dc.description.sponsorship | Instituto Nacional de Ciencia e Tecnologia (INCT) REGENERA | |
dc.description.sponsorship | National Health and Medical Research Council of AustraliaNational Health and Medical Research Council of Australia | |
dc.description.sponsorship | Coordenacao de Aperfeicoamento de Pessoal de N'ivel Superior-Brasil (CAPES)CAPES [001] | |
dc.language.iso | eng | |
dc.publisher | FEDERATION AMER SOC EXP BIOL | eng |
dc.relation.ispartof | Faseb Journal | |
dc.rights | restrictedAccess | eng |
dc.subject | glomerulopathy | eng |
dc.subject | podocyte | eng |
dc.subject | ADR nephropathy | eng |
dc.subject | SCFA | eng |
dc.subject.other | chain fatty-acids | eng |
dc.subject.other | dietary fiber | eng |
dc.subject.other | sodium-butyrate | eng |
dc.subject.other | inflammation | eng |
dc.subject.other | receptor | eng |
dc.subject.other | activation | eng |
dc.subject.other | glomerulosclerosis | eng |
dc.subject.other | acetylation | eng |
dc.subject.other | progression | eng |
dc.subject.other | expression | eng |
dc.title | Gut microbial metabolite butyrate protects against proteinuric kidney disease through epigenetic- and GPR109a-mediated mechanisms | eng |
dc.type | article | eng |
dc.rights.holder | Copyright FEDERATION AMER SOC EXP BIOL | eng |
dc.identifier.doi | 10.1096/fj.201901080R | |
dc.identifier.pmid | 31366236 | |
dc.subject.wos | Biochemistry & Molecular Biology | eng |
dc.subject.wos | Biology | eng |
dc.subject.wos | Cell Biology | eng |
dc.type.category | original article | eng |
dc.type.version | publishedVersion | eng |
hcfmusp.author.external | FELIZARDO, Raphael J. F.:Univ Fed Sao Paulo, Dept Med, Nephrol Div, Sao Paulo, Brazil; Univ Sao Paulo, Fac Med, Inst Biomed Sci 4, Dept Immunol, Sao Paulo, Brazil; Monash Univ, Dept Biochem & Mol Biol, Biodiscovery Inst, Clayton, Vic, Australia | |
hcfmusp.author.external | ALMEIDA, Danilo C. de:Univ Fed Sao Paulo, Dept Med, Nephrol Div, Sao Paulo, Brazil; Univ Sao Paulo, Fac Med, Inst Biomed Sci 4, Dept Immunol, Sao Paulo, Brazil | |
hcfmusp.author.external | PEREIRA, Rafael L.:Univ Fed Parana, Dept Physiol, Curitiba, Parana, Brazil | |
hcfmusp.author.external | WATANABE, Ingrid K. M.:Univ Fed Sao Paulo, Dept Med, Nephrol Div, Sao Paulo, Brazil; Univ Sao Paulo, Fac Med, Inst Biomed Sci 4, Dept Immunol, Sao Paulo, Brazil | |
hcfmusp.author.external | DOIMO, Nayara T. S.:Hosp Sirio Liban es, Ctr Mol Oncol, Sao Paulo, Brazil | |
hcfmusp.author.external | RIBEIRO, Willian R.:Univ Fed Sao Paulo, Inst Environm Chem & Pharmaceut Sci, Dept Pharmaceut Sci, Diadema, Brazil | |
hcfmusp.author.external | CENEDEZE, Marcos A.:Univ Fed Sao Paulo, Dept Med, Nephrol Div, Sao Paulo, Brazil | |
hcfmusp.author.external | HIYANE, Meire I.:Univ Sao Paulo, Fac Med, Inst Biomed Sci 4, Dept Immunol, Sao Paulo, Brazil | |
hcfmusp.author.external | AMANO, Mariane T.:Univ Sao Paulo, Fac Med, Inst Biomed Sci 4, Dept Immunol, Sao Paulo, Brazil; Hosp Sirio Liban es, Ctr Mol Oncol, Sao Paulo, Brazil | |
hcfmusp.author.external | BRAGA, Tarcio T.:Univ Sao Paulo, Fac Med, Inst Biomed Sci 4, Dept Immunol, Sao Paulo, Brazil | |
hcfmusp.author.external | FERREIRA, Caroline M.:Univ Fed Sao Paulo, Inst Environm Chem & Pharmaceut Sci, Dept Pharmaceut Sci, Diadema, Brazil | |
hcfmusp.author.external | PARMIGIANI, Raphael B.:Idengene Med Diagnost, Sao Paulo, Brazil | |
hcfmusp.author.external | ANDRADE-OLIVEIRA, Vinicius:Univ Sao Paulo, Fac Med, Inst Biomed Sci 4, Dept Immunol, Sao Paulo, Brazil | |
hcfmusp.author.external | VINOLO, Marco Aurelio R.:Univ Estadual Campinas, Inst Biol, Dept Genet Evolut Microbiol & Immunol, Campinas, Brazil | |
hcfmusp.author.external | MARINO, Eliana:Monash Univ, Dept Biochem & Mol Biol, Biodiscovery Inst, Clayton, Vic, Australia | |
hcfmusp.author.external | ROBERT, Remy:Monash Univ, Dept Biochem & Mol Biol, Biodiscovery Inst, Clayton, Vic, Australia | |
hcfmusp.author.external | MACKAY, Charles R.:Monash Univ, Dept Biochem & Mol Biol, Biodiscovery Inst, Clayton, Vic, Australia | |
hcfmusp.description.beginpage | 11894 | |
hcfmusp.description.endpage | 11908 | |
hcfmusp.description.issue | 11 | |
hcfmusp.description.volume | 33 | |
hcfmusp.origem | WOS | |
hcfmusp.origem.id | WOS:000507461600025 | |
hcfmusp.origem.id | 2-s2.0-85074378236 | |
hcfmusp.publisher.city | BETHESDA | eng |
hcfmusp.publisher.country | USA | eng |
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dc.description.index | MEDLINE | eng |
dc.identifier.eissn | 1530-6860 | |
hcfmusp.citation.scopus | 65 | |
hcfmusp.scopus.lastupdate | 2024-02-23 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - LIM/05 Artigos e Materiais de Revistas Científicas - LIM/12 Artigos e Materiais de Revistas Científicas - ODS/03 |
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