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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | |
dc.contributor.author | ROEH, Astrid | |
dc.contributor.author | MALCHOW, Berend | |
dc.contributor.author | LEVOLD, Katrin | |
dc.contributor.author | LABUSGA, Marcin | |
dc.contributor.author | KELLER-VARADY, Katriona | |
dc.contributor.author | SCHNEIDER-AXMANN, Thomas | |
dc.contributor.author | WOBROCK, Thomas | |
dc.contributor.author | SCHMITT, Andrea | |
dc.contributor.author | FALKAI, Peter | |
dc.contributor.author | HASAN, Alkomiet | |
dc.date.accessioned | 2020-03-24T15:02:51Z | - |
dc.date.available | 2020-03-24T15:02:51Z | - |
dc.date.issued | 2020 | |
dc.identifier.citation | NEUROPSYCHOBIOLOGY, v.79, n.1, p.100-107, 2020 | |
dc.identifier.issn | 0302-282X | |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/35710 | - |
dc.description.abstract | Background: Aerobic endurance training has been discussed to induce brain plasticity and improve cognitive functions in healthy subjects and patients with neuropsychiatric disorders. For schizophrenia, a motor cortical inhibitory deficit has been established as one aspect of impaired plasticity, especially involving impairments in GABAergic interneuron networks, but the possibility to restore these deficits via exercise-induced plasticity has not been evaluated yet. Methods: 17 schizophrenia patients and 16 matched healthy controls underwent 3 months of aerobic endurance training (30 min, 3 times a week) on bicycle ergometers. After 6 weeks, computer-assisted cognitive remediation training (30 min, 2 times a week) was added. Transcranial magnetic stimulation of the left and right hemispheres was performed at baseline and at the end of the intervention. We evaluated the intensity to induce a motor-evoked potential of 1 mV (S1mV), the resting motor threshold (RMT), the cortical silent period (CSP) at an intensity of 120 and 150% of the individual RMT, short-latency interval intracortical inhibition (3 ms), and intracortical facilitation (7 and 15 ms). Depending on the variable and hemisphere, follow-up data was available for 7-15 schizophrenia patients and for 10-12 healthy controls. Results: Repeated measures ANOVA revealed no significant time x group interactions for any of the analyzed variables. A significant increase in S1mV and CSP duration at 150% RMT of the left hemisphere could be observed in both groups over time. Conclusion: Regular ergometer training over 3 months increases motor cortical inhibition as displayed by an increase in CSP. The increase in S1mV may also indicate a higher degree of inhibition after the intervention. We could not establish a difference between schizophrenia patients and healthy controls. Due to the limited sample size, our results have to be considered as preliminary and need to be replicated in future trials. | eng |
dc.language.iso | eng | |
dc.publisher | KARGER | eng |
dc.relation.ispartof | Neuropsychobiology | |
dc.rights | restrictedAccess | eng |
dc.subject | Endurance training | eng |
dc.subject | Schizophrenia | eng |
dc.subject | Motor cortical excitability | eng |
dc.subject | Transcranial magnetic stimulation | eng |
dc.subject.other | transcranial magnetic stimulation | eng |
dc.subject.other | inhibition | eng |
dc.subject.other | exercise | eng |
dc.subject.other | plasticity | eng |
dc.title | Effects of Three Months of Aerobic Endurance Training on Motor Cortical Excitability in Schizophrenia Patients and Healthy Subjects | eng |
dc.type | article | eng |
dc.rights.holder | Copyright KARGER | eng |
dc.identifier.doi | 10.1159/000489714 | |
dc.identifier.pmid | 30001538 | |
dc.subject.wos | Neurosciences | eng |
dc.subject.wos | Psychiatry | eng |
dc.subject.wos | Psychology | eng |
dc.type.category | original article | eng |
dc.type.version | publishedVersion | eng |
hcfmusp.author.external | ROEH, Astrid:Ludwig Maximilians Univ Munchen, Dept Psychiat & Psychotherapy, Univ Hosp, Munich, Germany | |
hcfmusp.author.external | MALCHOW, Berend:Univ Hosp Jena, Dept Psychiat & Psychotherapy, Jena, Germany | |
hcfmusp.author.external | LEVOLD, Katrin:Georg August Univ, Dept Psychiat & Psychotherapy, Gottingen, Germany | |
hcfmusp.author.external | LABUSGA, Marcin:Georg August Univ, Dept Psychiat & Psychotherapy, Gottingen, Germany | |
hcfmusp.author.external | KELLER-VARADY, Katriona:Hannover Med Sch, Inst Sports Med, Hannover, Germany | |
hcfmusp.author.external | SCHNEIDER-AXMANN, Thomas:Ludwig Maximilians Univ Munchen, Dept Psychiat & Psychotherapy, Univ Hosp, Munich, Germany | |
hcfmusp.author.external | WOBROCK, Thomas:Georg August Univ, Dept Psychiat & Psychotherapy, Gottingen, Germany; Cty Hosp Darmstadt Dieburg, Dept Psychiat & Psychotherapy, Gross Umstadt, Gross Umstadt, Germany | |
hcfmusp.author.external | FALKAI, Peter:Ludwig Maximilians Univ Munchen, Dept Psychiat & Psychotherapy, Univ Hosp, Munich, Germany | |
hcfmusp.author.external | HASAN, Alkomiet:Ludwig Maximilians Univ Munchen, Dept Psychiat & Psychotherapy, Univ Hosp, Munich, Germany | |
hcfmusp.description.beginpage | 100 | |
hcfmusp.description.endpage | 107 | |
hcfmusp.description.issue | 1 | |
hcfmusp.description.volume | 79 | |
hcfmusp.origem | WOS | |
hcfmusp.origem.id | WOS:000510871600010 | |
hcfmusp.origem.id | 2-s2.0-85049899668 | |
hcfmusp.publisher.city | BASEL | eng |
hcfmusp.publisher.country | SWITZERLAND | eng |
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dc.description.index | MEDLINE | eng |
dc.identifier.eissn | 1423-0224 | |
hcfmusp.citation.scopus | 3 | - |
hcfmusp.scopus.lastupdate | 2024-03-29 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - LIM/27 |
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