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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorRAABE, Florian J.
dc.contributor.authorSLAPAKOVA, Lenka
dc.contributor.authorROSSNER, Moritz J.
dc.contributor.authorCANTUTI-CASTELVETRI, Ludovico
dc.contributor.authorSIMONS, Mikael
dc.contributor.authorFALKAI, Peter G.
dc.contributor.authorSCHMITT, Andrea
dc.identifier.citationCELLS, v.8, n.12, article ID 1496, 15p, 2019
dc.description.abstractImaging and postmortem studies have revealed disturbed oligodendroglia-related processes in patients with schizophrenia and provided much evidence for disturbed myelination, irregular gene expression, and altered numbers of oligodendrocytes in the brains of schizophrenia patients. Oligodendrocyte deficits in schizophrenia might be a result of failed maturation and disturbed regeneration and may underlie the cognitive deficits of the disease, which are strongly associated with impaired long-term outcome. Cognition depends on the coordinated activity of neurons and interneurons and intact connectivity. Oligodendrocyte precursors form a synaptic network with parvalbuminergic interneurons, and disturbed crosstalk between these cells may be a cellular basis of pathology in schizophrenia. However, very little is known about the exact axon-glial cellular and molecular processes that may be disturbed in schizophrenia. Until now, investigations were restricted to peripheral tissues, such as blood, correlative imaging studies, genetics, and molecular and histological analyses of postmortem brain samples. The advent of human-induced pluripotent stem cells (hiPSCs) will enable functional analysis in patient-derived living cells and holds great potential for understanding the molecular mechanisms of disturbed oligodendroglial function in schizophrenia. Targeting such mechanisms may contribute to new treatment strategies for previously treatment-resistant cognitive symptoms.eng
dc.description.sponsorshipGerman Research FoundationGerman Research Foundation (DFG) [SPP Glia RO 4076/3-1, FKZ RO 4076/5-1, RO 241/16-1, FA 241/16-1]
dc.description.sponsorshipElse Kroner-Fresenius Foundation
dc.subjectpluripotent stem cellseng
dc.subject.otherpluripotent stem-cellseng
dc.subject.otherwhite-matter integrityeng
dc.subject.othermyelin basic-proteineng
dc.subject.otherparvalbumin interneuronseng
dc.subject.otherefficient generationeng
dc.subject.otherprefrontal cortexeng
dc.titleOligodendrocytes as A New Therapeutic Target in Schizophrenia: From Histopathological Findings to Neuron-Oligodendrocyte Interactioneng
dc.rights.holderCopyright MDPIeng
dc.subject.wosCell Biologyeng
dc.type.versionpublishedVersioneng, Florian J.:Ludwig Maximilians Univ Munchen, Dept Psychiat & Psychotherapy, Univ Hosp, Nussbaumstr 7, D-80336 Munich, Germany; Int Max Planck Res Sch Translat Psychiat IMPRS TP, Kraepelinstr 2-10, D-80804 Munich, Germany; Ludwig Maximilians Univ Munchen, Dept Psychiat & Psychotherapy, Univ Hosp, Mol & Behav Neurobiol, D-80336 Munich, Germany, Lenka:Ludwig Maximilians Univ Munchen, Dept Psychiat & Psychotherapy, Univ Hosp, Nussbaumstr 7, D-80336 Munich, Germany; Int Max Planck Res Sch Translat Psychiat IMPRS TP, Kraepelinstr 2-10, D-80804 Munich, Germany, Moritz J.:Ludwig Maximilians Univ Munchen, Dept Psychiat & Psychotherapy, Univ Hosp, Mol & Behav Neurobiol, D-80336 Munich, Germany, Ludovico:German Ctr Neurodegenerat Dis DZNE, Feodor Lynen Str 17, D-81377 Munich, Germany, Mikael:German Ctr Neurodegenerat Dis DZNE, Feodor Lynen Str 17, D-81377 Munich, Germany; Munich Cluster Syst Neurol SyNergy, D-81377 Munich, Germany; Tech Univ Munich, Inst Neuronal Cell Biol, D-80805 Munich, Germany, Peter G.:Ludwig Maximilians Univ Munchen, Dept Psychiat & Psychotherapy, Univ Hosp, Nussbaumstr 7, D-80336 Munich, Germany
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