Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/35724
Title: Histopathologic Changes in Placental Tissue Associated With Vertical Transmission of Zika Virus
Authors: SANTOS, Geovane R.PINTO, Clovis A. L.PRUDENTE, Raphael C. S.BEVILACQUA, Estela M. A. F.WITKIN, Steven S.PASSOS, Saulo D.MORON, A. F.VENTURA, D. F.MASSAD, E.ZANOTTO, P. M. A.RODRIGUES, L. C.BERTOZZI, A. P. A. P.GRION, A. P.MINGOTTI, A. C.SILVA, A. C. B.MARTINS, C. M. G.BARREIRA, E. R.FUJIWARA, D. T.SOUZA, F. M. S.VELASCO, F. G.CANGERANA, F.ARITA, F. N.HERNANDEZ, F. D. M.TABARES, H. S.MILANI, H. J. F.SAMPAIO, M. M. S. C.MACHADO, M. B.SILVA, M. M. A.RODRIGUES, M. M. D.ALMEIDA, M. F.RIZZO, M. F.DAMICO, F. M.CLEMENTE, N. S.CUNHA, M. P.IZBICKI, R.GAZETA, R. E.DEZENA, R. C. A. B.BONOM, S. H. A.POUR, S. Z.URANJEC, S.ROSEMBERG, S.OYAMA, S. M. R.SARMENTO, S. G. P.QUINTELLA, T. M.FAJARDO, T. C. G.FERRARETO, T. R. G.RODRIGUES, W. M.BARAN, L.SOARES, A. P.COSTA, M.BARBONI, M. T. S.LIMA, DsFRANCA, V. C. R. M.VIDAL, K. S.BARBOSA, A. R.ZANQUETTA, G. U.SILVA, A. B.
Citation: INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY, v.39, n.2, p.157-162, 2020
Abstract: Zika virus (ZIKV) is highly neurotropic after crossing the placenta, inducing teratogenic effects that result in delayed development and microcephaly in infants. The available evidence for vertical transmission of this infection is based on placental studies showing alterations in trophoblastic tissue. However, complete characterization of ZIKV-infected placenta and involved pathways has yet to be fully clarified. This case report of placental ZIKV infection describes morphologic and molecular changes in the placenta. Hyperplasia of placental Hofbauer cells in chorionic villi and numerous histiocyte-like cells in the decidua were observed. The decidua, fibroblasts, and chorion, as well as circulating cells in the intravascular compartment stained positive for ZIKV envelop protein. Deciduitis was present on the maternal surface of the placenta, with a prevalence of lymphocytes associated with vasculitis. A high level of uncommitted CD3(+) T lymphocytes were present, in addition to CD4(+) and CD8(+) cells. Elevated expression of the apoptosis inhibitor, Bcl-2, was observed in syncytiotrophoblasts. These parameters may promote the persistence of ZIKV in placental tissue and transmission to the fetus.
Appears in Collections:Artigos e Materiais de Revistas Científicas - HU
Artigos e Materiais de Revistas Científicas - ODS/03

Files in This Item:
File Description SizeFormat 
art_SANTOS_Histopathologic_Changes_in_Placental_Tissue_Associated_With_Vertical_2020.PDF.pdf
  Restricted Access
publishedVersion (English)564.86 kBAdobe PDFView/Open Request a copy

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.