Please use this identifier to cite or link to this item:
https://observatorio.fm.usp.br/handle/OPI/35730
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | |
dc.contributor.author | LOPES, Thaisa Regina Rocha | |
dc.contributor.author | GONCALES, Juliana Prado | |
dc.contributor.author | SILVA JUNIOR, Jose Valter Joaquim | |
dc.contributor.author | LORENA, Virginia Maria Barros de | |
dc.contributor.author | TOSCANO, Ana Luiza Castro Conde | |
dc.contributor.author | AKAMATSU, Sandra Mitie | |
dc.contributor.author | SALLES, Angela Christina | |
dc.contributor.author | TOZETTO-MENDOZA, Tania Regina | |
dc.contributor.author | MORAIS, Viviane Martha Santos de | |
dc.contributor.author | COELHO, Maria Rosangela Cunha Duarte | |
dc.date.accessioned | 2020-03-24T15:16:55Z | |
dc.date.available | 2020-03-24T15:16:55Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | HUMAN IMMUNOLOGY, v.81, n.1, p.26-31, 2020 | |
dc.identifier.issn | 0198-8859 | |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/35730 | |
dc.description.abstract | Human gammaherpesvirus 8 (HHV-8) is the etiologic agent of Kaposi's sarcoma (KS), one of the most common cancers in people living with HIV/AIDS. It is believe that the course of both HIV and HHV-8 infection is associated with the imbalance of anti- and/or pro-inflammatory cytokines. Here, we evaluated the IL-6, TNF-alpha, IL-10, CCL2 and CXCL10 serum concentrations in HIV- and HIV/HHV-8 (without KS) individuals, and in patients with cutaneous or visceral AIDS-KS. Serum concentrations of IL-6, IL-10 and CXCL10 were significantly higher in the AIDS-KS group compared to HIV and HIV/HHV-8 individuals. Similarly, the concentrations of theses cytokines were higher in patients with visceral than in those with cutaneous AIDS-KS. The TNF-alpha concentration was significantly higher in the HIV group compared to HIV/HHV-8 (with and without KS) individuals, and CCL2 levels did not present significant difference among the groups. The HIV viral load was undetectable in all patients from the HIV and HIV/HHV-8 groups. On the other hand, in the AIDS-KS group, most patients had detectable HIV viral load. In this context, we believe that the cytokine levels in AIDS-KS may be result of a complex interaction between HIV, HHV-8 and immunity. | eng |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)National Council for Scientific and Technological Development (CNPq) | |
dc.description.sponsorship | Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)CAPES | |
dc.description.sponsorship | Fundacao de Amparo a Ciencia e Tecnologia de Pernambuco (FACEPE) | |
dc.language.iso | eng | |
dc.publisher | ELSEVIER SCIENCE INC | eng |
dc.relation.ispartof | Human Immunology | |
dc.rights | restrictedAccess | eng |
dc.subject | HIV/AIDS | eng |
dc.subject | HHV-8 | eng |
dc.subject | Kaposi's sarcoma | eng |
dc.subject | AIDS-KS | eng |
dc.subject | Pathogenesis | eng |
dc.subject.other | lytic cycle replication | eng |
dc.subject.other | c-reactive protein | eng |
dc.subject.other | growth-factor | eng |
dc.subject.other | gene-expression | eng |
dc.subject.other | hiv-infection | eng |
dc.subject.other | up-regulation | eng |
dc.subject.other | herpesvirus | eng |
dc.subject.other | interleukin-6 | eng |
dc.subject.other | pathogenesis | eng |
dc.subject.other | chemokine | eng |
dc.title | Association of IL-6, IL-10 and CXCL10 serum concentrations with visceral Kaposi's sarcoma in people living with HIV/AIDS | eng |
dc.type | article | eng |
dc.rights.holder | Copyright ELSEVIER SCIENCE INC | eng |
dc.identifier.doi | 10.1016/j.humimm.2019.11.007 | |
dc.identifier.pmid | 31866063 | |
dc.subject.wos | Immunology | eng |
dc.type.category | original article | eng |
dc.type.version | publishedVersion | eng |
hcfmusp.author.external | LOPES, Thaisa Regina Rocha:Univ Fed Pernambuco, Virol Sect, Lab Immunopathol Keizo Asami, Recife, PE, Brazil | |
hcfmusp.author.external | GONCALES, Juliana Prado:Univ Fed Pernambuco, Virol Sect, Lab Immunopathol Keizo Asami, Recife, PE, Brazil | |
hcfmusp.author.external | SILVA JUNIOR, Jose Valter Joaquim:Univ Fed Santa Maria, Dept Prevent Vet Med, Virol Sect, Santa Maria, RS, Brazil; Univ Fed Santa Maria, Dept Microbiol & Parasitol, Santa Maria, RS, Brazil | |
hcfmusp.author.external | LORENA, Virginia Maria Barros de:Fundacao Oswaldo Cruz, Aggeu Magalhiies Inst, Dept Immunol, Recife, PE, Brazil | |
hcfmusp.author.external | TOSCANO, Ana Luiza Castro Conde:Inst Infectol Emilio Ribas, Sao Paulo, Brazil | |
hcfmusp.author.external | AKAMATSU, Sandra Mitie:Inst Infectol Emilio Ribas, Sao Paulo, Brazil | |
hcfmusp.author.external | SALLES, Angela Christina:Inst Infectol Emilio Ribas, Sao Paulo, Brazil | |
hcfmusp.author.external | MORAIS, Viviane Martha Santos de:Univ Fed Pernambuco, Virol Sect, Lab Immunopathol Keizo Asami, Recife, PE, Brazil | |
hcfmusp.author.external | COELHO, Maria Rosangela Cunha Duarte:Univ Fed Pernambuco, Virol Sect, Lab Immunopathol Keizo Asami, Recife, PE, Brazil; Univ Fed Pernambuco, Ctr Biosci, Dept Physiol & Pharmacol, Recife, PE, Brazil | |
hcfmusp.description.beginpage | 26 | |
hcfmusp.description.endpage | 31 | |
hcfmusp.description.issue | 1 | |
hcfmusp.description.volume | 81 | |
hcfmusp.origem | WOS | |
hcfmusp.origem.id | WOS:000511233700008 | |
hcfmusp.origem.id | 2-s2.0-85076829675 | |
hcfmusp.publisher.city | NEW YORK | eng |
hcfmusp.publisher.country | USA | eng |
hcfmusp.relation.reference | Bergler-Czop B, 2016, POSTEP DERM ALERGOL, V33, P149, DOI 10.5114/ada.2016.59163 | eng |
hcfmusp.relation.reference | Bolanos R., 2018, CANC RES FRONT, V4, P45 | eng |
hcfmusp.relation.reference | Borges AH, 2016, J INFECT DIS, V214, P408, DOI 10.1093/infdis/jiw173 | eng |
hcfmusp.relation.reference | Borges AH, 2015, J INFECT DIS, V212, P585, DOI 10.1093/infdis/jiv123 | eng |
hcfmusp.relation.reference | Brinkmann MM, 2007, J VIROL, V81, P42, DOI 10.1128/JVI.00648-06 | eng |
hcfmusp.relation.reference | Cai J, 1997, BLOOD, V89, P1491, DOI 10.1182/blood.V89.5.1491.1491_1491_1500 | eng |
hcfmusp.relation.reference | Couty JP, 2009, J PHARMACOL EXP THER, V329, P1142, DOI 10.1124/jpet.108.147686 | eng |
hcfmusp.relation.reference | de Medeiros RM, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0156163 | eng |
hcfmusp.relation.reference | Denner J, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0055199 | eng |
hcfmusp.relation.reference | DiMaio TA, 2014, J VIROL, V88, P14301, DOI 10.1128/JVI.01696-14 | eng |
hcfmusp.relation.reference | El-Mallawany NK, 2019, INT J CANCER, V144, P110, DOI 10.1002/ijc.31863 | eng |
hcfmusp.relation.reference | Ensoli B, 2000, SEMIN CANCER BIOL, V10, P367, DOI 10.1006/scbi.2000.0329 | eng |
hcfmusp.relation.reference | Ensoli B, 2001, EUR J CANCER, V37, P1251, DOI 10.1016/S0959-8049(01)00121-6 | eng |
hcfmusp.relation.reference | Fatahzadeh M, 2012, OR SURG OR MED OR PA, V113, P2, DOI 10.1016/j.tripleo.2011.05.011 | eng |
hcfmusp.relation.reference | Ganem D, 2006, ANNU REV PATHOL-MECH, V1, P273, DOI 10.1146/annurev.pathol.1.110304.100133 | eng |
hcfmusp.relation.reference | Godinho NMO, 2008, FORENS SCI INT-GEN S, V1, P329, DOI 10.1016/j.fsigss.2007.10.069 | eng |
hcfmusp.relation.reference | Hensler HR, 2009, J GEN VIROL, V90, P79, DOI 10.1099/vir.0.006239-0 | eng |
hcfmusp.relation.reference | Huang SP, 2004, J BIOMED SCI, V11, P517, DOI 10.1159/000077902 | eng |
hcfmusp.relation.reference | Kawada K, 2007, ONCOGENE, V26, P4679, DOI 10.1038/sj.onc.1210267 | eng |
hcfmusp.relation.reference | Knowlton ER, 2014, MBIO, V5, DOI 10.1128/mBio.01277-14 | eng |
hcfmusp.relation.reference | KROWN SE, 1989, J CLIN ONCOL, V7, P1201, DOI 10.1200/JCO.1989.7.9.1201 | eng |
hcfmusp.relation.reference | Kumar A, 2013, MEDIAT INFLAMM, DOI 10.1155/2013/484378 | eng |
hcfmusp.relation.reference | Lidenge SJ, 2019, J INFECT DIS, V219, P1318, DOI 10.1093/infdis/jiy654 | eng |
hcfmusp.relation.reference | Machado PRL, 2014, VIRAL IMMUNOL, V27, P356, DOI 10.1089/vim.2013.0134 | eng |
hcfmusp.relation.reference | Lins TC, 2010, AM J HUM BIOL, V22, P187, DOI 10.1002/ajhb.20976 | eng |
hcfmusp.relation.reference | Lo BKK, 2010, AM J PATHOL, V176, P2435, DOI 10.2353/ajpath.2010.081059 | eng |
hcfmusp.relation.reference | Mait-Kaufman J, 2015, AIDS RES HUM RETROV, V31, P615, DOI [10.1089/aid.2014.0085, 10.1089/AID.2014.0085] | eng |
hcfmusp.relation.reference | Valverde-Villegas JM, 2018, INFECT GENET EVOL, V57, P51, DOI 10.1016/j.meegid.2017.11.002 | eng |
hcfmusp.relation.reference | Martellotta F, 2009, CURR HIV RES, V7, P634, DOI 10.2174/157016209789973619 | eng |
hcfmusp.relation.reference | Maurer T, 2007, NEW ENGL J MED, V357, P1352, DOI 10.1056/NEJMc070508 | eng |
hcfmusp.relation.reference | Mesri EA, 2010, NAT REV CANCER, V10, P707, DOI 10.1038/nrc2888 | eng |
hcfmusp.relation.reference | MILES SA, 1990, P NATL ACAD SCI USA, V87, P4068, DOI 10.1073/pnas.87.11.4068 | eng |
hcfmusp.relation.reference | Mtonga W, 2018, CURR HIV RES, V16, P231, DOI 10.2174/1570162X16666180711103610 | eng |
hcfmusp.relation.reference | Nascimento MC, 2007, J CLIN MICROBIOL, V45, P715, DOI 10.1128/JCM.01264-06 | eng |
hcfmusp.relation.reference | Oksenhendler E, 2000, BLOOD, V96, P2069, DOI 10.1182/blood.V96.6.2069.h8002069_2069_2073 | eng |
hcfmusp.relation.reference | Pena SDJ, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0017063 | eng |
hcfmusp.relation.reference | Provenzano G, 2003, ANN RHEUM DIS, V62, P680, DOI 10.1136/ard.62.7.680 | eng |
hcfmusp.relation.reference | Qin ZQ, 2010, J LEUKOCYTE BIOL, V87, P25, DOI 10.1189/jlb.0409251 | eng |
hcfmusp.relation.reference | Rohner E, 2017, PAN AFR MED J, V28, DOI 10.11604/pamj.2017.28.261.11300 | eng |
hcfmusp.relation.reference | Ruocco E, 2013, CLIN DERMATOL, V31, P413, DOI 10.1016/j.clindermatol.2013.01.008 | eng |
hcfmusp.relation.reference | SCIACCA FL, 1994, J IMMUNOL, V153, P4816 | eng |
hcfmusp.relation.reference | Simmons RP, 2013, AIDS, V27, P2505, DOI 10.1097/01.aids.0000432455.06476.bc | eng |
hcfmusp.relation.reference | Tasca KI, 2012, REV SOC BRAS MED TRO, V45, P663, DOI 10.1590/S0037-86822012000600002 | eng |
hcfmusp.relation.reference | Tedeschi R, 2015, ONCOTARGET, V6, P30334, DOI 10.18632/oncotarget.4571 | eng |
hcfmusp.relation.reference | Torre LA, 2015, CA-CANCER J CLIN, V65, P87, DOI 10.3322/caac.21262 | eng |
hcfmusp.relation.reference | Tso FY, 2018, PLOS PATHOG, V14, DOI 10.1371/journal.ppat.1006844 | eng |
hcfmusp.relation.reference | Uldrick TS, 2010, CLIN INFECT DIS, V51, P350, DOI 10.1086/654798 | eng |
hcfmusp.relation.reference | Ullum H, 1996, J ACQ IMMUN DEF SYND, V13, P93, DOI 10.1097/00042560-199609000-00013 | eng |
hcfmusp.relation.reference | Unemori P, 2013, AIDS, V27, P1735, DOI 10.1097/QAD.0b013e3283601144 | eng |
hcfmusp.relation.reference | Varthakavi V, 2002, VIROLOGY, V297, P270, DOI 10.1006/viro.2002.1434 | eng |
hcfmusp.relation.reference | Venketaraman V, 2011, HIV AIDS UPDATES BIO, P281 | eng |
hcfmusp.relation.reference | Wang Z, 2017, FRONT IMMUNOL, V8, DOI 10.3389/fimmu.2017.01274 | eng |
hcfmusp.relation.reference | Weiss E, 2004, J AM ACAD DERMATOL, V50, P657, DOI 10.1016/j.jaad.2003.11.075 | eng |
hcfmusp.relation.reference | West J, 2008, J VIROL, V82, P5440, DOI 10.1128/JVI.02590-07 | eng |
hcfmusp.relation.reference | Zeng Y, 2007, J VIROL, V81, P2401, DOI 10.1128/JVI.02024-06 | eng |
dc.description.index | MEDLINE | eng |
dc.identifier.eissn | 1879-1166 | |
hcfmusp.citation.scopus | 12 | - |
hcfmusp.scopus.lastupdate | 2024-03-29 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - IMT Artigos e Materiais de Revistas Científicas - LIM/52 Artigos e Materiais de Revistas Científicas - ODS/03 |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
art_LOPES_Association_of_IL6_IL10_and_CXCL10_serum_concentrations_2020.PDF.pdf Restricted Access | publishedVersion (English) | 605.32 kB | Adobe PDF | View/Open Request a copy |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.