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https://observatorio.fm.usp.br/handle/OPI/35738
Título: | Changes in cartilage, synovial cells and synovial fluid after malleolar fractures: What its importance for post-traumatic ankle osteoarthitis? |
Autor(es): | GODOY-SANTOS, A.L.; LOPES, D.; GIAROLA, I.; CESAR NETTO, C. de; RAMMELT, S. |
Parte de: | FUSS UND SPRUNGGELENK, v.17, n.2, p.68-74, 2019 |
Resumo: | Background: Despite advances in malleolar fractures treatment, the overall risk to develop posttraumatic ankle osteoarthritis after 20 years is almost 40%, especially bimalleolar Weber type B and C fractures and fractures involving the posterior tibial rim. Methods: We performed a systematic literature review of clinical studies targeting the changes in cartilage, synovial cells and synovial fluid after malleolar fractures. Results: The acute ankle injury initiates a sequence of biological events potentially leading to progressive articular surface damage resulting from inflammatory changes in cartilage, synovial tissue and synovial fluid. Conclusion: A better understanding of the molecular and histological changes induced by acute trauma may potentially lead to novel, targeted treatment of malleolar fractures besides anatomical reduction and adequate stabilization. © 2019 |
Aparece nas coleções: | Artigos e Materiais de Revistas Científicas - FM/MFT Artigos e Materiais de Revistas Científicas - HC/IOT Artigos e Materiais de Revistas Científicas - LIM/34 Artigos e Materiais de Revistas Científicas - LIM/41 |
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