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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorCARDOSO, J.V.
dc.contributor.authorMACHADO, D.E.
dc.contributor.authorSILVA, M.C. da
dc.contributor.authorBERARDO, P.T.
dc.contributor.authorFERRARI, R.
dc.contributor.authorABRãO, M.S.
dc.contributor.authorPERINI, J.A.
dc.description.abstractObjective: Endometriosis has a complex and multifactorial pathology, and it is considered one of the main causes of infertility nowadays. The angiogenic process, which involves remodeling of extracellular matrix, is crucial for the development of this disease, mainly by the action of the matrix metalloproteinase 3 (MMP-3). It is known that genetic factors can influence endometriosis, thus; we investigated the role of MMP3 276G>A polymorphism as a risk factor for the development of the disease and its symptoms. Study Design: This case-control study included 283 women with endometriosis (cases)and 217 women without the disease (controls)who were submitted to laparoscopic or laparotomy surgery. Real-time polymerase chain reaction performed by TaqMan system was applied for all polymorphisms. A multivariate logistic regression was performed to evaluate the association between polymorphism and endometriosis or clinical and gynecological characteristics of the disease, using their respective odds ratios (OR)and 95% confidence intervals (CI). Results: The allelic frequency of the MMP3 276 G > A polymorphism was 33.6% in controls and 40.3% in endometriosis cases. The allelic distribution was significantly different between the two (P = 0.03). The variant genotype of MMP3 276AA was associated with increased endometriosis risk in the advanced endometriosis cases (OR: 2.08, 95% CI: 1.05 – 4.07 and OR: 1.87, 95% CI: 1.01 – 3.45). Regarding the symptoms, endometriosis-related infertile women had a positive association with the presence of MMP3 276 G > A polymorphism (OR: 3.13, 95% CI: 1.08–9.08 and OR: 3.30, 95% CI: 1.31 – 8.33). Conclusions: These findings suggest that the MMP3 276A polymorphism is involved with advanced endometriosis cases and infertility, and these associations may implicate in the behavior of disease. © 2019eng
dc.relation.ispartofEuropean Journal of Obstetrics and Gynecology and Reproductive Biology: X
dc.subject.othercase control studyeng
dc.subject.othercontrolled studyeng
dc.subject.otherfemale infertilityeng
dc.subject.othergene frequencyeng
dc.subject.othergenetic associationeng
dc.subject.otherlaparoscopic surgeryeng
dc.subject.othermajor clinical studyeng
dc.subject.otherpelvis pain syndromeeng
dc.subject.otherpriority journaleng
dc.subject.otherrisk factoreng
dc.subject.othersingle nucleotide polymorphismeng
dc.titleMatrix metalloproteinases 3 polymorphism increases the risk of developing advanced endometriosis and infertility: A case-control studyeng
dc.rights.holderCopyright ELSEVIER IRELAND LTDeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng, J.V.:Programa de Pós-guaduação em Saúde Pública e Meio Ambiente, Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil, Laboratório de Pesquisa de Ciências Farmacêuticas, Unidade de Farmácia, Centro Universitário Estadual da Zona Oeste, Rio de Janeiro, RJ, Brazil, D.E.:Laboratório de Pesquisa de Ciências Farmacêuticas, Unidade de Farmácia, Centro Universitário Estadual da Zona Oeste, Rio de Janeiro, RJ, Brazil, M.C. da:Programa de Pós-guaduação em Saúde Pública e Meio Ambiente, Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil, Laboratório de Pesquisa de Ciências Farmacêuticas, Unidade de Farmácia, Centro Universitário Estadual da Zona Oeste, Rio de Janeiro, RJ, Brazil, P.T.:Serviço de Ginecologia, Hospital Federal dos Servidores do Estado, Rio de Janeiro, RJ, Brazil, Departamento de Ginecologia, Faculdade de Medicina, Universidade Estácio de Sá, Rio de Janeiro, RJ, Brazil, R.:Instituto de Ginecologia, Hospital Moncorvo Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil, J.A.:Programa de Pós-guaduação em Saúde Pública e Meio Ambiente, Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil, Laboratório de Pesquisa de Ciências Farmacêuticas, Unidade de Farmácia, Centro Universitário Estadual da Zona Oeste, Rio de Janeiro, RJ, Brazil
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LIM/58 - Laboratório de Ginecologia Estrutural e Molecular

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