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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorCARDOSO, J.V.
dc.contributor.authorMACHADO, D.E.
dc.contributor.authorSILVA, M.C. da
dc.contributor.authorBERARDO, P.T.
dc.contributor.authorFERRARI, R.
dc.contributor.authorABRãO, M.S.
dc.contributor.authorPERINI, J.A.
dc.date.accessioned2020-04-03T16:22:00Z-
dc.date.available2020-04-03T16:22:00Z-
dc.date.issued2019
dc.identifier.citationEUROPEAN JOURNAL OF OBSTETRICS AND GYNECOLOGY AND REPRODUCTIVE BIOLOGY: X, v.3, article ID 100041, p, 2019
dc.identifier.issn2590-1613
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/35746-
dc.description.abstractObjective: Endometriosis has a complex and multifactorial pathology, and it is considered one of the main causes of infertility nowadays. The angiogenic process, which involves remodeling of extracellular matrix, is crucial for the development of this disease, mainly by the action of the matrix metalloproteinase 3 (MMP-3). It is known that genetic factors can influence endometriosis, thus; we investigated the role of MMP3 276G>A polymorphism as a risk factor for the development of the disease and its symptoms. Study Design: This case-control study included 283 women with endometriosis (cases)and 217 women without the disease (controls)who were submitted to laparoscopic or laparotomy surgery. Real-time polymerase chain reaction performed by TaqMan system was applied for all polymorphisms. A multivariate logistic regression was performed to evaluate the association between polymorphism and endometriosis or clinical and gynecological characteristics of the disease, using their respective odds ratios (OR)and 95% confidence intervals (CI). Results: The allelic frequency of the MMP3 276 G > A polymorphism was 33.6% in controls and 40.3% in endometriosis cases. The allelic distribution was significantly different between the two (P = 0.03). The variant genotype of MMP3 276AA was associated with increased endometriosis risk in the advanced endometriosis cases (OR: 2.08, 95% CI: 1.05 – 4.07 and OR: 1.87, 95% CI: 1.01 – 3.45). Regarding the symptoms, endometriosis-related infertile women had a positive association with the presence of MMP3 276 G > A polymorphism (OR: 3.13, 95% CI: 1.08–9.08 and OR: 3.30, 95% CI: 1.31 – 8.33). Conclusions: These findings suggest that the MMP3 276A polymorphism is involved with advanced endometriosis cases and infertility, and these associations may implicate in the behavior of disease. © 2019eng
dc.language.isoeng
dc.publisherELSEVIER IRELAND LTDeng
dc.relation.ispartofEuropean Journal of Obstetrics and Gynecology and Reproductive Biology: X
dc.rightsopenAccesseng
dc.subjectAngiogenesiseng
dc.subjectEndometriosiseng
dc.subjectInfertilityeng
dc.subjectMMP3eng
dc.subjectPolymorphismseng
dc.subject.otherstromelysineng
dc.subject.otheradulteng
dc.subject.otherarticleeng
dc.subject.othercase control studyeng
dc.subject.othercontrolled studyeng
dc.subject.otherdyspareuniaeng
dc.subject.otherendometriosiseng
dc.subject.otherfemaleeng
dc.subject.otherfemale infertilityeng
dc.subject.othergene frequencyeng
dc.subject.othergenetic associationeng
dc.subject.othergenotypeeng
dc.subject.otherheredityeng
dc.subject.otherhumaneng
dc.subject.otherlaparoscopic surgeryeng
dc.subject.otherlaparotomyeng
dc.subject.othermajor clinical studyeng
dc.subject.otherpelvis pain syndromeeng
dc.subject.otherpriority journaleng
dc.subject.otherrisk factoreng
dc.subject.othersingle nucleotide polymorphismeng
dc.titleMatrix metalloproteinases 3 polymorphism increases the risk of developing advanced endometriosis and infertility: A case-control studyeng
dc.typearticleeng
dc.rights.holderCopyright ELSEVIER IRELAND LTDeng
dc.identifier.doi10.1016/j.eurox.2019.100041
dc.identifier.pmid31404425
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
hcfmusp.author.externalCARDOSO, J.V.:Programa de Pós-guaduação em Saúde Pública e Meio Ambiente, Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil, Laboratório de Pesquisa de Ciências Farmacêuticas, Unidade de Farmácia, Centro Universitário Estadual da Zona Oeste, Rio de Janeiro, RJ, Brazil
hcfmusp.author.externalMACHADO, D.E.:Laboratório de Pesquisa de Ciências Farmacêuticas, Unidade de Farmácia, Centro Universitário Estadual da Zona Oeste, Rio de Janeiro, RJ, Brazil
hcfmusp.author.externalSILVA, M.C. da:Programa de Pós-guaduação em Saúde Pública e Meio Ambiente, Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil, Laboratório de Pesquisa de Ciências Farmacêuticas, Unidade de Farmácia, Centro Universitário Estadual da Zona Oeste, Rio de Janeiro, RJ, Brazil
hcfmusp.author.externalBERARDO, P.T.:Serviço de Ginecologia, Hospital Federal dos Servidores do Estado, Rio de Janeiro, RJ, Brazil, Departamento de Ginecologia, Faculdade de Medicina, Universidade Estácio de Sá, Rio de Janeiro, RJ, Brazil
hcfmusp.author.externalFERRARI, R.:Instituto de Ginecologia, Hospital Moncorvo Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
hcfmusp.author.externalPERINI, J.A.:Programa de Pós-guaduação em Saúde Pública e Meio Ambiente, Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil, Laboratório de Pesquisa de Ciências Farmacêuticas, Unidade de Farmácia, Centro Universitário Estadual da Zona Oeste, Rio de Janeiro, RJ, Brazil
hcfmusp.description.articlenumber100041
hcfmusp.description.volume3
hcfmusp.origemSCOPUS
hcfmusp.origem.id2-s2.0-85065871334
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hcfmusp.citation.scopus3-
hcfmusp.scopus.lastupdate2022-06-03-
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LIM/58 - Laboratório de Ginecologia Estrutural e Molecular


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