LIM/63 - Laboratório de Investigação Médica em Sono

O Laboratório de Investigação Médica em Sono é ligado ao Departamento de Cardiopneumologia da Faculdade de Medicina da Universidade de São Paulo (FMUSP).

Linhas de pesquisa: fisiopatologia da apneia do sono; desenvolvimento de tratamentos comportamentais e psicológicos para problemas de sono; ensaios clínicos não farmacológicos para insônia; investigação de variáveis psicológicas e ambientais que possam influenciar na manutenção e desenvolvimento da insônia; investigação de fatores responsáveis pelo sucesso e insucesso de diferentes tratamentos psicológicos e comportamentais para insônia; psicologia do sono; distúrbios de sono e doença cardiovascular; distúrbios do sono com enfoque principal nos distúrbios respiratórios do sono: métodos diagnósticos, fisiopatologia, consequências e tratamento.

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Recent Submissions

  1. Less may be more: CPAP vs. APAP in the treatment of obstructive sleep apnea

    JORNAL BRASILEIRO DE PNEUMOLOGIA, v.47, n.6, article ID e20210455, 2p, 2021

  2. Acceptance and commitment therapy-based behavioral intervention for insomnia: a pilot randomized controlled trial

    BRAZILIAN JOURNAL OF PSYCHIATRY, v.43, n.5, p.504-509, 2021

    Objective: To evaluate a protocol for acceptance and commitment therapy-based behavioral intervention for insomnia (ACT-BBI-I) in adults compared to cognitive behavioral therapy for insomnia (CBT-I). Methods: Forty-five adults with chronic insomnia were randomized to ACT-BBI-I or CBT-I. Both inte...

  3. Influence of obstructive sleep apnea on auditory event-related potentials

    SLEEP AND BREATHING, v.26, n.1, p.315-323, 2022

    Purpose To evaluate the influence of obstructive sleep apnea (OSA) on the P300 response of auditory event-related potentials (ERPs) and to correlate the electrophysiological findings with OSA severity. Methods Patients with no OSA and mild, moderate, and severe OSA according to polysomnography (P...

  4. Reply: Salt, Diuretics, and Obstructive Sleep Apnea

    ANNALS OF THE AMERICAN THORACIC SOCIETY, v.18, n.12, p.2103-2104, 2021

  5. Effect of CPAP treatment on BP in resistant hypertensive patients according to the BP dipping pattern and the presence of nocturnal hypertension

    HYPERTENSION RESEARCH, v.45, n.3, p.436-444, 2022

    High heterogeneity in the blood pressure (BP) response to continuous positive airway pressure (CPAP) exists in patients with resistant hypertension (RH). Only nondipper normotensive and hypertensive patients exhibited BP reductions when treated with CPAP; the baseline BP dipping pattern has been ...

  6. Effect of Continuous Positive Airway Pressure on Lipid Profiles in Obstructive Sleep Apnea: A Meta-Analysis

    JOURNAL OF CLINICAL MEDICINE, v.11, n.3, article ID 596, 10p, 2022

    Background: Obstructive sleep apnea (OSA) is associated with dyslipidemia. However, the effects of continuous positive airway pressure (CPAP) treatment on lipid profiles are unclear. Methods: PubMed/Medline, Embase and Cochrane were searched up to July 2021. Randomized controlled trials (RCTs) of...

  7. Economic evaluation of CPAP therapy for obstructive sleep apnea: a scoping review and evidence map

    SLEEP AND BREATHING, v.26, n.1, p.17-30, 2022

    Purpose To synthesize findings of economic evaluations investigating cost-effectiveness of continuous positive airway pressure (CPAP) for obstructive sleep apnea (OSA) and of strategies of organization of care related to CPAP therapy. Methods Scoping review with searches conducted in MEDLINE, CRD...


    SLEEP, v.42, suppl.1, 2019

  9. Intranasal Leptin Prevents Opioid-induced Deaths in Mice

    FASEB JOURNAL, v.35, suppl.1, Special Issue, 2021

  10. Postural balance in COPD with sleep disorders: a cross-sectional controlled study

    EUROPEAN RESPIRATORY JOURNAL, v.58, suppl.65, 2021