LIM/63 - Laboratório de Investigação Médica em Sono

O Laboratório de Investigação Médica em Sono é ligado ao Departamento de Cardiopneumologia da Faculdade de Medicina da Universidade de São Paulo (FMUSP).

Linhas de pesquisa: fisiopatologia da apneia do sono; desenvolvimento de tratamentos comportamentais e psicológicos para problemas de sono; ensaios clínicos não farmacológicos para insônia; investigação de variáveis psicológicas e ambientais que possam influenciar na manutenção e desenvolvimento da insônia; investigação de fatores responsáveis pelo sucesso e insucesso de diferentes tratamentos psicológicos e comportamentais para insônia; psicologia do sono; distúrbios de sono e doença cardiovascular; distúrbios do sono com enfoque principal nos distúrbios respiratórios do sono: métodos diagnósticos, fisiopatologia, consequências e tratamento.

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Recent Submissions

  1. Distribution of leptin receptors in the brain stem: possible route in the pathophysiology of neuromuscular control of airway resistance during sleep

    SLEEP MEDICINE, v.93, p.56-62, 2022

    Introduction: Leptin, a hormone related to satiety, has been studied because of its association with obesity and sleep apnea. The distribution of leptin receptors in the brain stem, and in the hypoglossal nucleus, has not yet been described. The stimulation of these muscles has been studied in th...

  2. Patients with Obstructive Sleep Apnea on Oronasal Continuous Positive Airway Pressure Breathe Predominantly through the Nose during Natural Sleep


  3. Sleep apnea and atrial fibrillation: the spell of Groundhog Day

    JOURNAL OF CLINICAL SLEEP MEDICINE, v.18, n.5, p.1223-1224, 2022

  4. Carotid intima-media thickness and flow-mediated dilation do not predict acute in-hospital outcomes in patients hospitalized with COVID-19


    Studies have suggested a potential role of endothelial dysfunction and atherosclerosis in the pathophysiology of COVID-19. Herein, we tested whether brachial flow-mediated dilation (FMD) and carotid intima-media thickness (cIMT) measured upon hospital admission are associated with acute in-hospit...

  5. Insomnia episodes, new-onset pharmacological treatments, and other sleep disturbances during the COVID-19 pandemic: a nationwide cross-sectional study in Brazilian health care professionals

    JOURNAL OF CLINICAL SLEEP MEDICINE, v.18, n.2, p.373-382, 2022

    Study Objectives: To evaluate the impact of the coronavirus disease 2019 (COVID-19) pandemic on insomnia and other sleep disturbances in health care professionals. Methods: A survey was distributed using social media and organizational emails to Brazilian active health care professionals during t...

  6. COVID-19 pandemic is associated with increased sleep disturbances and mental health symptoms but not help-seeking: a cross-sectional nation-wide study

    SLEEP SCIENCE, v.15, n.1, p.1-7, 2022

    Objective: This study aimed firstly to describe sleep-related and mental health symptoms before and during the COVID-19 pandemic in a national-wide sample and, secondly, to verify attitudes towards help-seeking to treat these symptoms. Material and Methods: Data were collected through an online q...

  7. Less may be more: CPAP vs. APAP in the treatment of obstructive sleep apnea

    JORNAL BRASILEIRO DE PNEUMOLOGIA, v.47, n.6, article ID e20210455, 2p, 2021

  8. Acceptance and commitment therapy-based behavioral intervention for insomnia: a pilot randomized controlled trial

    BRAZILIAN JOURNAL OF PSYCHIATRY, v.43, n.5, p.504-509, 2021

    Objective: To evaluate a protocol for acceptance and commitment therapy-based behavioral intervention for insomnia (ACT-BBI-I) in adults compared to cognitive behavioral therapy for insomnia (CBT-I). Methods: Forty-five adults with chronic insomnia were randomized to ACT-BBI-I or CBT-I. Both inte...

  9. Influence of obstructive sleep apnea on auditory event-related potentials

    SLEEP AND BREATHING, v.26, n.1, p.315-323, 2022

    Purpose To evaluate the influence of obstructive sleep apnea (OSA) on the P300 response of auditory event-related potentials (ERPs) and to correlate the electrophysiological findings with OSA severity. Methods Patients with no OSA and mild, moderate, and severe OSA according to polysomnography (P...

  10. Reply: Salt, Diuretics, and Obstructive Sleep Apnea

    ANNALS OF THE AMERICAN THORACIC SOCIETY, v.18, n.12, p.2103-2104, 2021