LIM/66 - Laboratório de Investigação Médica em Envelhecimento

O Laboratório de Investigação Médica em Envelhecimento é ligado ao Departamento de Departamento de Clínica Médica da Faculdade de Medicina da Universidade de São Paulo (FMUSP).

Linhas de pesquisa: bases epidemiológicas do envelhecimento; capacidade intrínseca; fragilidade; sarcopenia; condições agudas e críticas no envelhecimento; bases educacionais no envelhecimento; promoção do envelhecimento saudável.

Site oficial: http://lim-66-laboratorio-de-investigacao-medica-em-envelhecimento/


Recent Submissions

  1. Macrophage Polarization in the Perivascular Fat Was Associated With Coronary Atherosclerosis

    JOURNAL OF THE AMERICAN HEART ASSOCIATION, v.11, n.6, article ID e023274, 30p, 2022

    Background Inflammation of the perivascular adipose tissue (PvAT) may be related to atherosclerosis; however, the association of polarized macrophages in the pericoronary PvAT with measurements of atherosclerosis components in humans has not been fully investigated. Methods and Results Coronary a...

  2. B and T Lymphocyte Densities Remain Stable With Age in Human Cortex

    ASN NEURO, v.13, article ID 17590914211018117, 11p, 2021

    One hallmark of human aging is increased brain inflammation represented by glial activation. With age, there is also diminished function of the adaptive immune system, and modest decreases in circulating B- and T-lymphocytes. Lymphocytes traffic through the human brain and reside there in small n...

  3. Physical activity level is associated with gait performance and five times sit-to-stand in Parkinson's disease individuals

    ACTA NEUROLOGICA BELGICA, v.122, n.1, p.191-196, 2022

    Background Physical activity (PA) level is decreased in individuals with Parkinson ' s disease (PD). To increase the PA level improves both motor and non-motor symptoms of this population. It is known that gait performance and five times sit-to-stand (FTSTS) are associated with PA level; therefor...

  4. A prospective cross-sectional study estimated glomerular filtration rate from creatinine and cystatin C in adults with solid tumors

    KIDNEY INTERNATIONAL, v.101, n.3, p.607-614, 2022

    Current guidelines recommend estimating glomerular filtration rate (eGFR) using creatinine (eGFRcr) with the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation as the first test for GFR evaluation, but the Cockcroft-Gault (CG) equation is still commonly used in oncology practice...

  5. Neuroinflammation in Alzheimer's Disease: Focus on NLRP1 and NLRP3 Inflammasomes

    CURRENT PROTEIN & PEPTIDE SCIENCE, v.22, n.8, p.584-598, 2021

    Alzheimer's disease (AD) is the main cause of dementia worldwide. The definitive diagnosis of AD is clinicopathological and based on the identification of cerebral deposition of Amyloid beta (A beta) plaques and neurofibrillary tangles. However, the link between amyloid cascade and depositions of...

  6. The modulation of neuroinflammation by inducible nitric oxide synthase


    The accumulation and propagation of misfolded proteins in the brain is a pathological hallmark shared by many neurodegenerative diseases, such as the depositions of beta-amyloid and hyperphosphorylated tau proteins in Alzheimer's disease. Initial evidence shows the role of nitric oxide synthases ...

  7. TH1 lymphocytes in the perivascular adipose tissue correlate with plaque composition and increase the risk of intraplaque haemorrhages in coronary arteries: an autopsy study

    EUROPEAN HEART JOURNAL, v.42, suppl.1, p.1088-1088, 2021

  8. Association between functionality and respiratory impairment after hospitalization for COVID-19: a cohort study

    EUROPEAN RESPIRATORY JOURNAL, v.58, suppl.65, 2021


    EUROPEAN RESPIRATORY JOURNAL, v.58, suppl.65, 2021

  10. Icterícia

    Brandão Neto, Rodrigo Antonio; Santos, Fabio Pires de Souza; Satomi, Erika. Icterícia. In: Velasco, Irineu Tadeu; Brandão Neto, Rodrigo Antonio; Souza, Heraldo Possolo de; Marino, Lucas Oliveira; Marchini, Júlio Flávio Meirelles; Alencar, Júlio César Garcia de (eds). Medicina de emergência: abordagem prática [14.ed.]. BARUERI: Manole, 2020. p.341-351.