Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/35809
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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorLU, Xiaona
dc.contributor.authorFORTE, Antonio Jorge
dc.contributor.authorWILSON, Alexander
dc.contributor.authorSTEINBACHER, Derek M.
dc.contributor.authorALPEROVICH, Michael
dc.contributor.authorALONSO, Nivaldo
dc.contributor.authorPERSING, John A.
dc.date.accessioned2020-06-01T14:46:01Z
dc.date.available2020-06-01T14:46:01Z
dc.date.issued2020
dc.identifier.citationPLASTIC AND RECONSTRUCTIVE SURGERY, v.145, n.4, p.790E-802E, 2020
dc.identifier.issn0032-1052
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/35809
dc.description.abstractBackground: Apert syndrome causes normal or enlarged intracranial volume overall as patients grow. This study aimed to trace the segmental anterior, middle, and posterior cranial fossae volume and structural morphology in these patients, to help discern a more focused and individualized surgical treatment plan for patients with Apert syndrome. Methods: This study included 82 preoperative computed tomographic scans (Apert, n = 32; control, n = 50) divided into five age-related subgroups. The scans were measured using image processing and three-dimensional modeling software. Results: The middle cranial fossa volume was increased and was the earliest change noted. It was increased by 45 percent (p = 0.023) compared with controls before 6 months of age and remained increased into adulthood (161 percent, p = 0.016), with gradually increasing severity. The anterior and posterior cranial fossae volumes also increased, by 35 percent (p = 0.032) and 39 percent (p = 0.007), respectively. Increased depth of cranial fossae contributed most to the increase in volumes of patients with Apert syndrome, with correlation coefficients of 0.799, 0.908, and 0.888 for anterior, middle, and posterior cranial fossa, respectively. The intracranial volume was increased 12 percent (p = 0.098) across the entire test age range (0 to 26 years old), but only had statistical significance during the age range of 6 to 18 years (22 percent, p = 0.001). Conclusions: Malformation of the middle cranial fossa is an early, perhaps the initial, pivotal cranial morphologic change in Apert syndrome. Increased cranial fossae depth is an inherent characteristic of the maldevelopment. Normalization of cranial volume and circumference overall may not achieve a normal skull structure, as it does not correct regional craniocerebral disproportion.eng
dc.language.isoeng
dc.publisherLIPPINCOTT WILLIAMS & WILKINSeng
dc.relation.ispartofPlastic and Reconstructive Surgery
dc.rightsrestrictedAccesseng
dc.subject.othercentral-nervous-systemeng
dc.subject.otherintracranial volumeeng
dc.subject.othervault expansioneng
dc.subject.otherposterior-fossaeng
dc.subject.otherskull baseeng
dc.subject.otherchildreneng
dc.subject.otherpressureeng
dc.subject.othercrouzoneng
dc.subject.othercraniosynostosiseng
dc.subject.othergrowtheng
dc.titleCranial Fossa Volume and Morphology Development in Apert Syndromeeng
dc.typearticleeng
dc.rights.holderCopyright LIPPINCOTT WILLIAMS & WILKINSeng
dc.identifier.doi10.1097/PRS.0000000000006679
dc.identifier.pmid32221226
dc.subject.wosSurgeryeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
hcfmusp.author.externalPERSING, John A.:hinese Acad Med Sci, Peking Union Med Coll, Plast Surg Hosp, Beijing, Peoples R China
hcfmusp.description.beginpage790E
hcfmusp.description.endpage802E
hcfmusp.description.issue4
hcfmusp.description.volume145
hcfmusp.origemWOS
hcfmusp.origem.idWOS:000530618900015
hcfmusp.origem.id2-s2.0-85069591565
hcfmusp.publisher.cityPHILADELPHIAeng
hcfmusp.publisher.countryUSAeng
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dc.description.indexMEDLINEeng
dc.identifier.eissn1529-4242
hcfmusp.citation.scopus6-
hcfmusp.scopus.lastupdate2022-04-29-
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Artigos e Materiais de Revistas Científicas - FM/MCG
Departamento de Cirurgia - FM/MCG

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - LIM/04
LIM/04 - Laboratório de Microcirurgia


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