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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorDIAS, Olivia Meira-
dc.contributor.authorBALDI, Bruno Guedes-
dc.contributor.authorFERREIRA, Jeferson George-
dc.contributor.authorCARDENAS, Leticia Zumpano-
dc.contributor.authorPENNATI, Francesca-
dc.contributor.authorSALITO, Caterina-
dc.contributor.authorCARVALHO, Carlos Roberto Ribeiro-
dc.contributor.authorALIVERTI, Andrea-
dc.contributor.authorALBUQUERQUE, Andre Luis Pereira de-
dc.identifier.citationERJ OPEN RESEARCH, v.4, n.3, article ID UNSP 043, 11p, 2018-
dc.description.abstractSmall airway and interstitial pulmonary involvements are prominent in chronic hypersensitivity pneumonitis (cHP). However, their roles on exercise limitation and the relationship with functional lung tests have not been studied in detail. Our aim was to evaluate exercise performance and its determinants in cHP. We evaluated maximal cardiopulmonary exercise testing performance in 28 cHP patients (forced vital capacity 57 +/- 17% pred) and 18 healthy controls during cycling. Patients had reduced exercise performance with lower peak oxygen production (16.6 (12.3-19.98) versus 25.1 (16.9-32.0), p=0.003), diminished breathing reserve (% maximal voluntary ventilation) (12 (6.4-34.8)% versus 41 (32.7-50.8)%, p<0.001) and hyperventilation (minute ventilation/carbon dioxide production slope 37 +/- 5 versus 31 +/- 4, p<0.001). All patients presented oxygen desaturation and augmented Borg dyspnoea scores (8 (5-10) versus 4 (1-7), p=0.004). The prevalence of dynamic hyperinflation was found in only 18% of patients. When comparing cHP patients with normal and low peak oxygen production (<84% pred, lower limit of normal), the latter exhibited a higher minute ventilation/carbon dioxide production slope (39 +/- 5.0 versus 34 +/- 3.6, p=0.004), lower tidal volume (0.84 (0.78-0.90) L versus 1.15 (0.97-1.67) L, p=0.002), and poorer physical functioning score on the Short form-36 health survey. Receiver operating characteristic curve analysis showed that reduced lung volumes (forced vital capacity %, total lung capacity % and diffusing capacity of the lung for carbon dioxide %) were high predictors of poor exercise capacity. Reduced exercise capacity was prevalent in patients because of ventilatory limitation and not due to dynamic hyperinflation. Reduced lung volumes were reliable predictors of lower performance during exercise.eng
dc.description.sponsorshipEuropean Respiratory Society-
dc.relation.ispartofErj Open Research-
dc.titleMechanisms of exercise limitation in patients with chronic hypersensitivity pneumonitiseng
dc.subject.wosRespiratory Systemeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng, Francesca:Politecn Milan, Dipartimento Elettron Informaz & Bioingn, Milan, Italy-, Caterina:Politecn Milan, Dipartimento Elettron Informaz & Bioingn, Milan, Italy-, Andrea:Politecn Milan, Dipartimento Elettron Informaz & Bioingn, Milan, Italy-
hcfmusp.description.articlenumberUNSP 043-
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Appears in Collections:

Artigos e Materiais de Revistas Científicas - FM/MCP
Departamento de Cardio-Pneumologia - FM/MCP

Artigos e Materiais de Revistas Científicas - HC/InCor
Instituto do Coração - HC/InCor

Artigos e Materiais de Revistas Científicas - LIM/09
LIM/09 - Laboratório de Pneumologia

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