Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/35904
Full metadata record
DC FieldValueLanguage
dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorDIAS, Olivia Meira-
dc.contributor.authorBALDI, Bruno Guedes-
dc.contributor.authorFERREIRA, Jeferson George-
dc.contributor.authorCARDENAS, Leticia Zumpano-
dc.contributor.authorPENNATI, Francesca-
dc.contributor.authorSALITO, Caterina-
dc.contributor.authorCARVALHO, Carlos Roberto Ribeiro-
dc.contributor.authorALIVERTI, Andrea-
dc.contributor.authorALBUQUERQUE, Andre Luis Pereira de-
dc.date.accessioned2020-06-01T14:50:23Z-
dc.date.available2020-06-01T14:50:23Z-
dc.date.issued2018-
dc.identifier.citationERJ OPEN RESEARCH, v.4, n.3, article ID UNSP 043, 11p, 2018-
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/35904-
dc.description.abstractSmall airway and interstitial pulmonary involvements are prominent in chronic hypersensitivity pneumonitis (cHP). However, their roles on exercise limitation and the relationship with functional lung tests have not been studied in detail. Our aim was to evaluate exercise performance and its determinants in cHP. We evaluated maximal cardiopulmonary exercise testing performance in 28 cHP patients (forced vital capacity 57 +/- 17% pred) and 18 healthy controls during cycling. Patients had reduced exercise performance with lower peak oxygen production (16.6 (12.3-19.98) mL.kg(-1).min(-1) versus 25.1 (16.9-32.0), p=0.003), diminished breathing reserve (% maximal voluntary ventilation) (12 (6.4-34.8)% versus 41 (32.7-50.8)%, p<0.001) and hyperventilation (minute ventilation/carbon dioxide production slope 37 +/- 5 versus 31 +/- 4, p<0.001). All patients presented oxygen desaturation and augmented Borg dyspnoea scores (8 (5-10) versus 4 (1-7), p=0.004). The prevalence of dynamic hyperinflation was found in only 18% of patients. When comparing cHP patients with normal and low peak oxygen production (<84% pred, lower limit of normal), the latter exhibited a higher minute ventilation/carbon dioxide production slope (39 +/- 5.0 versus 34 +/- 3.6, p=0.004), lower tidal volume (0.84 (0.78-0.90) L versus 1.15 (0.97-1.67) L, p=0.002), and poorer physical functioning score on the Short form-36 health survey. Receiver operating characteristic curve analysis showed that reduced lung volumes (forced vital capacity %, total lung capacity % and diffusing capacity of the lung for carbon dioxide %) were high predictors of poor exercise capacity. Reduced exercise capacity was prevalent in patients because of ventilatory limitation and not due to dynamic hyperinflation. Reduced lung volumes were reliable predictors of lower performance during exercise.eng
dc.description.sponsorshipEuropean Respiratory Society-
dc.language.isoeng-
dc.publisherEUROPEAN RESPIRATORY SOC JOURNALS LTDeng
dc.relation.ispartofErj Open Research-
dc.rightsopenAccesseng
dc.titleMechanisms of exercise limitation in patients with chronic hypersensitivity pneumonitiseng
dc.typearticleeng
dc.rights.holderCopyright EUROPEAN RESPIRATORY SOC JOURNALS LTDeng
dc.identifier.doi10.1183/23120541.00043-2018-
dc.identifier.pmid30151370-
dc.subject.wosRespiratory Systemeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
hcfmusp.author.externalPENNATI, Francesca:Politecn Milan, Dipartimento Elettron Informaz & Bioingn, Milan, Italy-
hcfmusp.author.externalSALITO, Caterina:Politecn Milan, Dipartimento Elettron Informaz & Bioingn, Milan, Italy-
hcfmusp.author.externalALIVERTI, Andrea:Politecn Milan, Dipartimento Elettron Informaz & Bioingn, Milan, Italy-
hcfmusp.description.articlenumberUNSP 043-
hcfmusp.description.issue3-
hcfmusp.description.volume4-
hcfmusp.origemWOS-
hcfmusp.origem.idWOS:000532516800009-
hcfmusp.origem.id2-s2.0-85065193571-
hcfmusp.publisher.citySHEFFIELDeng
hcfmusp.publisher.countryENGLANDeng
hcfmusp.relation.referenceArcasoy SM, 2003, AM J RESP CRIT CARE, V167, P735, DOI 10.1164/rccm.200210-1130OCeng
hcfmusp.relation.referenceArmstrong HF, 2014, RESPIROLOGY, V19, P675, DOI 10.1111/resp.12306eng
hcfmusp.relation.referenceATS, 2003, AM J RESP CRIT CARE, V167, P211, DOI 10.1164/rccm.167.2.211eng
hcfmusp.relation.referenceBaldi BG, 2012, AM J RESP CRIT CARE, V186, P341, DOI 10.1164/rccm.201203-0372OCeng
hcfmusp.relation.referenceBORG GAV, 1982, MED SCI SPORT EXER, V14, P377, DOI 10.1249/00005768-198205000-00012eng
hcfmusp.relation.referenceCalverley PMA, 2005, EUR RESPIR J, V25, P186, DOI 10.1183/09031936.04.00113204eng
hcfmusp.relation.referenceCiconelli RM, 1999, REV BRAS REUMATOL, V39, P143, DOI 10.1590/S0482-50042010000300005eng
hcfmusp.relation.referenceDias OM, 2018, EXPERT REV RESP MED, V12, P5, DOI 10.1080/17476348.2018.1395282eng
hcfmusp.relation.referencedu Bois RM, 2014, EUR RESPIR J, V43, P1421, DOI 10.1183/09031936.00131813eng
hcfmusp.relation.referenceDu Plessis JP, 2018, RESPIROLOGY, V23, P392, DOI 10.1111/resp.13226eng
hcfmusp.relation.referenceElbehairy AF, 2015, AM J RESP CRIT CARE, V191, P1384, DOI 10.1164/rccm.201501-0157OCeng
hcfmusp.relation.referenceErkinjuntti-Pekkanen R, 1998, AM J RESP CRIT CARE, V158, P662, DOI 10.1164/ajrccm.158.2.9710012eng
hcfmusp.relation.referenceGIBSON GJ, 1977, AM REV RESPIR DIS, V116, P637, DOI 10.1164/arrd.1977.116.4.637eng
hcfmusp.relation.referenceGuenette JA, 2013, PULM MED, V2013, DOI 10.1155/2013/956081eng
hcfmusp.relation.referenceZuniga SG, 2017, RESPIROLOGY, V22, P1637, DOI 10.1111/resp.13124eng
hcfmusp.relation.referenceHanak V, 2007, MAYO CLIN PROC, V82, P812, DOI 10.4065/82.7.812eng
hcfmusp.relation.referenceHou PC, 2017, CHEST, V152, P22, DOI [10.1016/j.chest.2017.01.010, 10.1016/j.chest.2017.02.011]eng
hcfmusp.relation.referenceJensen D, 2009, RESP PHYSIOL NEUROBI, V167, P87, DOI 10.1016/j.resp.2009.01.011eng
hcfmusp.relation.referenceLacasse Y, 2003, AM J RESP CRIT CARE, V168, P952, DOI 10.1164/rccm.200301-137OCeng
hcfmusp.relation.referenceLacasse Y, 2012, CHEST, V142, P208, DOI 10.1378/chest.11-2479eng
hcfmusp.relation.referenceLacasse Y, 2009, INT ARCH ALLERGY IMM, V149, P161, DOI 10.1159/000189200eng
hcfmusp.relation.referenceLALANCETTE M, 1993, AM REV RESPIR DIS, V148, P216, DOI 10.1164/ajrccm/148.1.216eng
hcfmusp.relation.referenceLammi MR, 2015, CURR RESPIR MED REV, V11, P163, DOI 10.2174/1573398X11666150619183527eng
hcfmusp.relation.referenceLederer DJ, 2006, AM J RESP CRIT CARE, V174, P659, DOI 10.1164/rccm.200604-520OCeng
hcfmusp.relation.referenceMacIntyre N, 2005, EUR RESPIR J, V26, P720, DOI 10.1183/09031936.05.00034905eng
hcfmusp.relation.referenceMARCINIUK DD, 1994, CHEST, V105, P183, DOI 10.1378/chest.105.1.183eng
hcfmusp.relation.referenceMARCINIUK DD, 1994, J APPL PHYSIOL, V77, P963eng
hcfmusp.relation.referenceMiller MR, 2005, EUR RESPIR J, V26, P319, DOI 10.1183/09031936.05.00034805eng
hcfmusp.relation.referenceNathan SD, 2008, RESP MED, V102, P1305, DOI 10.1016/j.rmed.2008.03.022eng
hcfmusp.relation.referenceNeder JA, 1999, EUR RESPIR J, V14, P1304, DOI 10.1183/09031936.99.14613049eng
hcfmusp.relation.referenceNeder JA, 1999, BRAZ J MED BIOL RES, V32, P729, DOI 10.1590/S0100-879X1999000600008eng
hcfmusp.relation.referenceO'Donnell DE, 2009, EUR RESPIR J, V34, P866, DOI 10.1183/09031936.00168708eng
hcfmusp.relation.referenceO'Donnell DE, 1998, J APPL PHYSIOL, V84, P2000eng
hcfmusp.relation.referenceO'Donnell DE, 2001, AM J RESP CRIT CARE, V164, P770, DOI 10.1164/ajrccm.164.5.2012122eng
hcfmusp.relation.referenceO'Donnell DE, 2000, J APPL PHYSIOL, V88, P1859eng
hcfmusp.relation.referenceOliveira RKF, 2014, EUR RESPIR J, V44, P415, DOI 10.1183/09031936.00010414eng
hcfmusp.relation.referenceOlson AL, 2016, PATIENT-RELAT OUTCOM, V7, P29, DOI 10.2147/PROM.S74857eng
hcfmusp.relation.referencePanagiotou M, 2016, CHRON RESP DIS, V13, P162, DOI 10.1177/1479972315626014eng
hcfmusp.relation.referencePereira Carlos Alberto de Castro, 2007, J. bras. pneumol., V33, P397, DOI 10.1590/S1806-37132007000400008eng
hcfmusp.relation.referenceRolland-Debord C, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0170035eng
hcfmusp.relation.referenceRussell AM, 2015, BMC MED, V13, DOI 10.1186/s12916-015-0475-4eng
hcfmusp.relation.referenceSchwaiblmair M, 1997, EUR RESPIR J, V10, P2360, DOI 10.1183/09031936.97.10102360eng
hcfmusp.relation.referenceSELMANLAMA M, 1993, CLIN CHEST MED, V14, P699eng
hcfmusp.relation.referenceSilva CIS, 2008, RADIOLOGY, V246, P288, DOI 10.1148/radiol.2453061881eng
hcfmusp.relation.referenceSilva CIS, 2007, AM J ROENTGENOL, V188, P334, DOI 10.2214/AJR.05.1826eng
hcfmusp.relation.referenceSTUBBING DG, 1980, J APPL PHYSIOL, V49, P511eng
hcfmusp.relation.referenceVasakova M, 2017, AM J RESP CRIT CARE, V196, P680, DOI 10.1164/rccm.201611-2201PPeng
hcfmusp.relation.referenceVogiatzis I, 2005, THORAX, V60, P723, DOI 10.1136/thx.2004.039115eng
hcfmusp.relation.referenceWanger J, 2005, EUR RESPIR J, V26, P511, DOI 10.1183/09031936.05.00035005eng
hcfmusp.relation.referenceWare JE, 2000, SPINE, V25, P3130, DOI 10.1097/00007632-200012150-00008eng
hcfmusp.relation.referenceYERNAULT JC, 1975, B PHYSIO-PATHOL RESP, V11, P231eng
dc.description.indexPubMedeng
dc.identifier.eissn2312-0541-
hcfmusp.citation.scopus8-
hcfmusp.scopus.lastupdate2022-05-12-
Appears in Collections:

Artigos e Materiais de Revistas Científicas - FM/MCP
Departamento de Cardio-Pneumologia - FM/MCP

Artigos e Materiais de Revistas Científicas - HC/InCor
Instituto do Coração - HC/InCor

Artigos e Materiais de Revistas Científicas - LIM/09
LIM/09 - Laboratório de Pneumologia


Files in This Item:
File Description SizeFormat 
art_DIAS_Mechanisms_of_exercise_limitation_in_patients_with_chronic_2018.PDFpublishedVersion (English)595.89 kBAdobe PDFThumbnail
View/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.