Please use this identifier to cite or link to this item:
https://observatorio.fm.usp.br/handle/OPI/35917
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | |
dc.contributor.author | ANTUNES, Fernanda | |
dc.contributor.author | PEREIRA, Gustavo J. S. | |
dc.contributor.author | SAITO, Renata F. | |
dc.contributor.author | V, Marcus Buri | |
dc.contributor.author | GAGLIARDI, Mara | |
dc.contributor.author | BINCOLETTO, Claudia | |
dc.contributor.author | CHAMMAS, Roger | |
dc.contributor.author | FIMIA, Gian Maria | |
dc.contributor.author | PIACENTINI, Mauro | |
dc.contributor.author | CORAZZARI, Marco | |
dc.contributor.author | SMAILI, Soraya Soubhi | |
dc.date.accessioned | 2020-06-01T14:50:48Z | - |
dc.date.available | 2020-06-01T14:50:48Z | - |
dc.date.issued | 2020 | |
dc.identifier.citation | CELLS, v.9, n.3, article ID 640, 18p, 2020 | |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/35917 | - |
dc.description.abstract | Skin melanoma is one of the most aggressive and difficult-to-treat human malignancies, characterized by poor survival rates, thus requiring urgent novel therapeutic approaches. Although metabolic reprogramming has represented so far, a cancer hallmark, accumulating data indicate a high plasticity of cancer cells in modulating cellular metabolism to adapt to a heterogeneous and continuously changing microenvironment, suggesting a novel therapeutic approach for dietary manipulation in cancer therapy. To this aim, we exposed melanoma cells to combined nutrient-restriction/sorafenib. Results indicate that cell death was efficiently induced, with apoptosis representing the prominent feature. In contrast, autophagy was blocked in the final stage by this treatment, similarly to chloroquine, which also enhanced melanoma cell sensitization to combined treatment. Energy stress was evidenced by associated treatment with mitochondrial dysfunction and glycolysis impairment, suggesting metabolic stress determining melanoma cell death. A reduction of tumor growth after cycles of intermittent fasting together with sorafenib treatment was also observed in vivo, reinforcing that the nutrient shortage can potentiate anti-melanoma therapy. Our findings showed that the restriction of nutrients by intermittent fasting potentiates the effects of sorafenib due to the modulation of cellular metabolism, suggesting that it is possible to harness the energy of cancer cells for the treatment of melanoma. | eng |
dc.description.sponsorship | Italian Association for Cancer Research-AIRCAssociazione Italiana per la Ricerca sul Cancro (AIRC) [MFAG 11749, 17404, 15244] | |
dc.description.sponsorship | Italian Ministry of University and Research (FIRB Accordi di Programma 2011)Ministry of Education, Universities and Research (MIUR) [PRIN 2015 20152CB22L] | |
dc.description.sponsorship | Italian Ministry of HealthMinistry of Health, Italy | |
dc.description.sponsorship | Russian Government Program for the Recruitment of the leading scientists into the Russian Institutions of Higher Education [14. W03.31.0029] | |
dc.description.sponsorship | Fundacao de Amparo a Pesquisa do Estado de Sao PauloFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [FAPESP-2012/08273-3, 2013/20073-2, 2017/10863-7] | |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Cientifico e TecnologicoNational Council for Scientific and Technological Development (CNPq) [CNPq-163612/2013-7, PVE 401236/2014-5, PVE 401141/2014-4] | |
dc.description.sponsorship | Coordenacao de Aperfeicoamento de Pessoal deNivel Superior-Brasil (CAPES)CAPES | |
dc.description.sponsorship | Financiadora de Estudos e Projetos (FINEP)Ciencia Tecnologia e Inovacao (FINEP) | |
dc.description.sponsorship | Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) | |
dc.language.iso | eng | |
dc.publisher | MDPI | eng |
dc.relation.ispartof | Cells | |
dc.rights | openAccess | eng |
dc.subject | apoptosis | eng |
dc.subject | energy stress | eng |
dc.subject | melanoma | eng |
dc.subject | autophagy | eng |
dc.subject | sorafenib | eng |
dc.subject.other | down-regulation | eng |
dc.subject.other | cancer-cells | eng |
dc.subject.other | molecular-mechanisms | eng |
dc.subject.other | tumor-growth | eng |
dc.subject.other | er stress | eng |
dc.subject.other | autophagy | eng |
dc.subject.other | inhibition | eng |
dc.subject.other | apoptosis | eng |
dc.subject.other | metabolism | eng |
dc.subject.other | ambra1 | eng |
dc.title | Effective Synergy of Sorafenib and Nutrient Shortage in Inducing Melanoma Cell Death through Energy Stress | eng |
dc.type | article | eng |
dc.rights.holder | Copyright MDPI | eng |
dc.identifier.doi | 10.3390/cells9030640 | |
dc.identifier.pmid | 32155825 | |
dc.subject.wos | Cell Biology | eng |
dc.type.category | original article | eng |
dc.type.version | publishedVersion | eng |
hcfmusp.author.external | ANTUNES, Fernanda:Univ Fed Sao Paulo, Paulista Sch Med, Dept Pharmacol, BR-04021001 Sao Paulo, Brazil | |
hcfmusp.author.external | PEREIRA, Gustavo J. S.:Univ Fed Sao Paulo, Paulista Sch Med, Dept Pharmacol, BR-04021001 Sao Paulo, Brazil | |
hcfmusp.author.external | V, Marcus Buri:Univ Fed Sao Paulo, Paulista Sch Med, Dept Mol Biol, BR-04021001 Sao Paulo, Brazil | |
hcfmusp.author.external | GAGLIARDI, Mara:Univ Piemonte Orientale, Dept Hlth Sci DISS, I-28100 Novara, Italy; Ctr Translat Res Autoimmune & Allerg Dis CAAD, I-28100 Novara, Italy | |
hcfmusp.author.external | BINCOLETTO, Claudia:Univ Fed Sao Paulo, Paulista Sch Med, Dept Pharmacol, BR-04021001 Sao Paulo, Brazil | |
hcfmusp.author.external | FIMIA, Gian Maria:Natl Inst Infect Dis IRCCS Lazzaro Spallanzani, Dept Epidemiol & Preclin Res, I-00149 Rome, Italy; Univ Roma La Sapienza, Dept Mol Med, I-00185 Rome, Italy | |
hcfmusp.author.external | PIACENTINI, Mauro:Natl Inst Infect Dis IRCCS Lazzaro Spallanzani, Dept Epidemiol & Preclin Res, I-00149 Rome, Italy; Russian Acad Sci, Inst Cytol, St Petersburg 199034, Russia | |
hcfmusp.author.external | CORAZZARI, Marco:Univ Piemonte Orientale, Dept Hlth Sci DISS, I-28100 Novara, Italy; Ctr Translat Res Autoimmune & Allerg Dis CAAD, I-28100 Novara, Italy; Univ Piemonte Orientale, Dept Hlth Sci, I-28100 Novara, Italy; Univ Piemonte Orientale, IRCAD, I-28100 Novara, Italy | |
hcfmusp.author.external | SMAILI, Soraya Soubhi:Univ Fed Sao Paulo, Paulista Sch Med, Dept Pharmacol, BR-04021001 Sao Paulo, Brazil | |
hcfmusp.description.articlenumber | 640 | |
hcfmusp.description.issue | 3 | |
hcfmusp.description.volume | 9 | |
hcfmusp.origem | WOS | |
hcfmusp.origem.id | WOS:000529337400117 | |
hcfmusp.origem.id | 2-s2.0-85083844827 | |
hcfmusp.publisher.city | BASEL | eng |
hcfmusp.publisher.country | SWITZERLAND | eng |
hcfmusp.relation.reference | Abildgaard C, 2015, TRENDS MOL MED, V21, P164, DOI 10.1016/j.molmed.2014.12.007 | eng |
hcfmusp.relation.reference | Antonioli M, 2017, TRENDS BIOCHEM SCI, V42, P28, DOI 10.1016/j.tibs.2016.09.008 | eng |
hcfmusp.relation.reference | Antonioli M, 2014, DEV CELL, V31, P734, DOI 10.1016/j.devcel.2014.11.013 | eng |
hcfmusp.relation.reference | Antunes F, 2018, CHEM-BIOL INTERACT, V281, P89, DOI 10.1016/j.cbi.2017.12.027 | eng |
hcfmusp.relation.reference | Antunes F, 2017, BIOCHEM BIOPH RES CO, V485, P16, DOI 10.1016/j.bbrc.2016.09.149 | eng |
hcfmusp.relation.reference | Armstrong JL, 2011, CLIN CANCER RES, V17, P2216, DOI 10.1158/1078-0432.CCR-10-3003 | eng |
hcfmusp.relation.reference | Austin M, 2005, J BIOL CHEM, V280, P33280, DOI 10.1074/jbc.M508187200 | eng |
hcfmusp.relation.reference | Bhattacharya B, 2016, BRIT J PHARMACOL, V173, P970, DOI 10.1111/bph.13422 | eng |
hcfmusp.relation.reference | Bianchi G, 2015, ONCOTARGET, V6, P11806, DOI 10.18632/oncotarget.3688 | eng |
hcfmusp.relation.reference | Bonuccelli G, 2010, CELL CYCLE, V9, P3506, DOI 10.4161/cc.9.17.12731 | eng |
hcfmusp.relation.reference | Bull VH, 2012, J PROTEOME RES, V11, P1609, DOI 10.1021/pr200790e | eng |
hcfmusp.relation.reference | Chae YK, 2018, J IMMUNOTHER CANCER, V6, DOI 10.1186/s40425-018-0349-3 | eng |
hcfmusp.relation.reference | Chaube B, 2015, CELL DEATH DISCOV, V1, DOI 10.1038/cddiscovery.2015.63 | eng |
hcfmusp.relation.reference | Chen YS, 2015, MOL MED REP, V12, P1645, DOI 10.3892/mmr.2015.3623 | eng |
hcfmusp.relation.reference | Corazzari M, 2015, CELL DEATH DIFFER, V22, P946, DOI 10.1038/cdd.2014.183 | eng |
hcfmusp.relation.reference | Corazzari M, 2013, SEMIN CANCER BIOL, V23, P337, DOI 10.1016/j.semcancer.2013.07.001 | eng |
hcfmusp.relation.reference | Corazzari M, 2012, AUTOPHAGY, V8, P1255, DOI 10.4161/auto.20671 | eng |
hcfmusp.relation.reference | Damy SB, 2010, REV ASSOC MED BRAS, V56, P103, DOI 10.1590/S0104-42302010000100024 | eng |
hcfmusp.relation.reference | Dang CV, 2012, GENE DEV, V26, P877, DOI 10.1101/gad.189365.112 | eng |
hcfmusp.relation.reference | Di Biase S, 2016, MOL CELL ONCOL, V3, DOI 10.1080/23723556.2015.1117701 | eng |
hcfmusp.relation.reference | Dirks WG, 2010, INT J CANCER, V126, P303, DOI 10.1002/ijc.24999 | eng |
hcfmusp.relation.reference | Dwarakanath BS, 2009, J CANCER RES THER, V5, P21, DOI 10.4103/0973-1482.55136 | eng |
hcfmusp.relation.reference | Eckelman WC, 2007, NUCL MED BIOL, V34, P229, DOI 10.1016/j.nucmedbio.2007.01.005 | eng |
hcfmusp.relation.reference | Elgendy M, 2015, AUTOPHAGY, V11, P581, DOI 10.1080/15548627.2015.1029836 | eng |
hcfmusp.relation.reference | Escudier B, 2014, ANN ONCOL, V25, P49, DOI 10.1093/annonc/mdu259 | eng |
hcfmusp.relation.reference | Fan LX, 2013, BBA-GEN SUBJECTS, V1830, P5175, DOI 10.1016/j.bbagen.2013.07.010 | eng |
hcfmusp.relation.reference | Farooque A, 2009, J CANCER RES THER, V5, P32, DOI 10.4103/0973-1482.55138 | eng |
hcfmusp.relation.reference | Fecteau JF, 2012, MOL MED, V18, P19, DOI 10.2119/molmed.2011.00164 | eng |
hcfmusp.relation.reference | Fumarola C, 2013, BREAST CANCER RES TR, V141, P67, DOI 10.1007/s10549-013-2668-x | eng |
hcfmusp.relation.reference | Gagliardi M, 2019, CELL DEATH DIS, V10, DOI 10.1038/s41419-019-2143-7 | eng |
hcfmusp.relation.reference | Giglio P, 2018, ONCOIMMUNOLOGY, V7, DOI 10.1080/2162402X.2018.1466765 | eng |
hcfmusp.relation.reference | Giglio P, 2015, MOL CELL ONCOL, V2, DOI 10.4161/23723556.2014.995016 | eng |
hcfmusp.relation.reference | Gojo I, 2002, CLIN CANCER RES, V8, P3527 | eng |
hcfmusp.relation.reference | Guadarrama-Orozco JA, 2016, CLIN TRANSL ONCOL, V18, P863, DOI 10.1007/s12094-015-1469-6 | eng |
hcfmusp.relation.reference | Hao CY, 2017, MEDICINE, V96, DOI 10.1097/MD.0000000000007325 | eng |
hcfmusp.relation.reference | Katz SI, 2009, CANCER BIOL THER, V8, P2406, DOI 10.4161/cbt.8.24.10824 | eng |
hcfmusp.relation.reference | Kharaziha P, 2015, ONCOTARGET, V6, P37066, DOI 10.18632/oncotarget.5797 | eng |
hcfmusp.relation.reference | Koppenol WH, 2011, NAT REV CANCER, V11, P325, DOI 10.1038/nrc3038 | eng |
hcfmusp.relation.reference | Lachaier E, 2014, ANTICANCER RES, V34, P6417 | eng |
hcfmusp.relation.reference | Lalaoui N, 2015, SEMIN CELL DEV BIOL, V39, P63, DOI 10.1016/j.semcdb.2015.02.003 | eng |
hcfmusp.relation.reference | Lee C, 2012, SCI TRANSL MED, V4, DOI 10.1126/scitranslmed.3003293 | eng |
hcfmusp.relation.reference | Levesque S, 2019, ONCOIMMUNOLOGY, V8, DOI 10.1080/2162402X.2019.1591878 | eng |
hcfmusp.relation.reference | Liu XY, 2016, CELL MOL NEUROBIOL, V36, P1197, DOI 10.1007/s10571-015-0318-z | eng |
hcfmusp.relation.reference | Longo VD, 2014, CELL METAB, V19, P181, DOI 10.1016/j.cmet.2013.12.008 | eng |
hcfmusp.relation.reference | Louandre C, 2015, CANCER LETT, V356, P971, DOI 10.1016/j.canlet.2014.11.014 | eng |
hcfmusp.relation.reference | Marino G, 2014, NAT REV MOL CELL BIO, V15, P81, DOI 10.1038/nrm3735 | eng |
hcfmusp.relation.reference | Oliverio S, 2014, AMINO ACIDS, V46, P2767, DOI 10.1007/s00726-014-1821-0 | eng |
hcfmusp.relation.reference | Pagliarini V, 2012, CELL DEATH DIFFER, V19, P1495, DOI 10.1038/cdd.2012.27 | eng |
hcfmusp.relation.reference | Pagliarini V, 2015, J CELL SCI, V128, P1166, DOI 10.1242/jcs.164103 | eng |
hcfmusp.relation.reference | Panka DJ, 2006, CANCER RES, V66, P1611, DOI 10.1158/0008-5472.CAN-05-0808 | eng |
hcfmusp.relation.reference | Peng YF, 2013, AUTOPHAGY, V9, P2056, DOI 10.4161/auto.26398 | eng |
hcfmusp.relation.reference | Ramirez-Labrada A, 2015, CLIN TRANSL ONCOL, V17, P121, DOI 10.1007/s12094-014-1201-y | eng |
hcfmusp.relation.reference | Raoul JL, 2018, CANCER TREAT REV, V68, P16, DOI 10.1016/j.ctrv.2018.05.006 | eng |
hcfmusp.relation.reference | Ratnikov BI, 2017, ONCOGENE, V36, P147, DOI 10.1038/onc.2016.198 | eng |
hcfmusp.relation.reference | Ross FA, 2017, CELL CHEM BIOL, V24, P813, DOI 10.1016/j.chembiol.2017.05.021 | eng |
hcfmusp.relation.reference | Safdie F, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0044603 | eng |
hcfmusp.relation.reference | Shimizu S, 2012, INT J CANCER, V131, P548, DOI 10.1002/ijc.26374 | eng |
hcfmusp.relation.reference | Simone BA, 2013, FUTURE ONCOL, V9, P959, DOI [10.2217/fon.13.31, 10.2217/FON.13.31] | eng |
hcfmusp.relation.reference | Sottnik JL, 2011, CLIN EXP METASTAS, V28, P865, DOI 10.1007/s10585-011-9417-5 | eng |
hcfmusp.relation.reference | Suliman HB, 2015, PHARMACOL REV, V68, P20, DOI 10.1124/pr.115.011502 | eng |
hcfmusp.relation.reference | Tan ZQ, 2016, MOL CANCER THER, V15, P774, DOI 10.1158/1535-7163.MCT-15-0621 | eng |
hcfmusp.relation.reference | Ward PS, 2012, CANCER CELL, V21, P297, DOI 10.1016/j.ccr.2012.02.014 | eng |
hcfmusp.relation.reference | Weinberg F, 2010, P NATL ACAD SCI USA, V107, P8788, DOI 10.1073/pnas.1003428107 | eng |
hcfmusp.relation.reference | Weng CJ, 2005, J BIOL CHEM, V280, P10491, DOI 10.1074/jbc.M412819200 | eng |
hcfmusp.relation.reference | Xu XD, 2015, ONCOL RES TREAT, V38, P117, DOI 10.1159/000375435 | eng |
hcfmusp.relation.reference | Youle RJ, 2012, SCIENCE, V337, P1062, DOI 10.1126/science.1219855 | eng |
hcfmusp.relation.reference | Zhang CG, 2017, J BIOL CHEM, V292, P15105, DOI 10.1074/jbc.M117.783175 | eng |
dc.description.index | MEDLINE | eng |
dc.identifier.eissn | 2073-4409 | |
hcfmusp.citation.scopus | 7 | - |
hcfmusp.scopus.lastupdate | 2024-03-29 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MDR Artigos e Materiais de Revistas Científicas - HC/ICESP Artigos e Materiais de Revistas Científicas - LIM/24 Artigos e Materiais de Revistas Científicas - ODS/03 |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
art_ANTUNES_Effective_Synergy_of_Sorafenib_and_Nutrient_Shortage_in_2020.PDF | publishedVersion (English) | 2.84 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.