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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | |
dc.contributor.author | BRUSTIA, Raffaele | |
dc.contributor.author | LANGELLA, Serena | |
dc.contributor.author | KAWAI, Takayuki | |
dc.contributor.author | FONSECA, Gilton Marques | |
dc.contributor.author | SCHIELKE, Astrid | |
dc.contributor.author | COLLI, Fabio | |
dc.contributor.author | RESENDE, Vivian | |
dc.contributor.author | FLERES, Francesco | |
dc.contributor.author | ROULIN, Didier | |
dc.contributor.author | LEYMAN, Paul | |
dc.contributor.author | GIACOMONI, Alessandro | |
dc.contributor.author | GRANGER, Benjamin | |
dc.contributor.author | FARTOUX, Laetitia | |
dc.contributor.author | CARLIS, Luciano De | |
dc.contributor.author | DEMARTINES, Nicolas | |
dc.contributor.author | SOMMACALE, Daniele | |
dc.contributor.author | SANCHES, Marcelo Dias | |
dc.contributor.author | PATRONO, Damiano | |
dc.contributor.author | DETRY, Olivier | |
dc.contributor.author | HERMAN, Paulo | |
dc.contributor.author | OKUMURA, Shinya | |
dc.contributor.author | FERRERO, Alessandro | |
dc.contributor.author | SCATTON, Olivier | |
dc.date.accessioned | 2020-06-01T14:52:45Z | - |
dc.date.available | 2020-06-01T14:52:45Z | - |
dc.date.issued | 2020 | |
dc.identifier.citation | EJSO, v.46, n.4, p.560-571, 2020 | |
dc.identifier.issn | 0748-7983 | |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/35959 | - |
dc.description.abstract | Purpose: A preoperative risk score (PRS) to predict outcome of patients with intrahepatic cholangiocarcinoma treated by liver surgery could be clinically relevant.To assess accuracy for broadly adoption, external validation of predictive models on independent datasets is crucial. The objective of this study was to externally validate the score for prediction of long-term outcomes after liver surgery for intrahepatic cholangiocarcinoma proposed by Sasaki et al. and based on preoperative albumin, neutrophil-to-lymphocytes-ratio, CA19-9 and tumor size. Methods: Patients treated by liver surgery for intrahepatic cholangiocarcinoma at 11 international HPB centers from 2001 to 2018 were included in the external validation cohort. Harrell's c-index and HosmerLemeshow analyses were used to test PRS discrimination and calibration. Kaplan-Meier curve for risk groups as described in the original study were displayed. Results: A total of 355 patients with 174 deaths during the follow-up period (median = 41.7 months, IQR 32.8-50.6) were included. The median PRS value was 14.7 (IQR 10.7-20.6), with normal distribution across the cohort. A Cox regression on PRS covariates found coefficients similar to those of the derivation cohort, except for tumor size. Measures of discrimination estimated by Harrell's c-index was 0.61(95% CI:0.56-0.67) and Hosmer-Lemeshow p = 0.175. The Kaplan-Meyer estimation showed reasonable discrimination across risk groups, with 5years survival rate ranging from 20.1% to 0%. Conclusion: In this external validation cohort, the PRS had mild discrimination and poor calibration performance, similarly to the original publication. Nevertheless, its ability to identify different classes of risk is clinically useful, for a better tailoring of a therapeutic strategy. | eng |
dc.language.iso | eng | |
dc.publisher | ELSEVIER SCI LTD | eng |
dc.relation.ispartof | Ejso | |
dc.rights | restrictedAccess | eng |
dc.subject | Liver surgery | eng |
dc.subject | Intra-hepatic cholangiocarcinoma | eng |
dc.subject | Prognostic score | eng |
dc.subject | External validation | eng |
dc.subject | Long-term outcomes | eng |
dc.subject.other | resection | eng |
dc.subject.other | impact | eng |
dc.title | Preoperative risk score for prediction of long-term outcomes after hepatectomy for intrahepatic cholangiocarcinoma: Report of a collaborative, international-based, external validation study | eng |
dc.type | article | eng |
dc.rights.holder | Copyright ELSEVIER SCI LTD | eng |
dc.identifier.doi | 10.1016/j.ejso.2019.10.041 | |
dc.identifier.pmid | 31718919 | |
dc.subject.wos | Oncology | eng |
dc.subject.wos | Surgery | eng |
dc.type.category | original article | eng |
dc.type.version | publishedVersion | eng |
hcfmusp.author.external | BRUSTIA, Raffaele:Hop La Pitie Salpetriere, AP HP, Dept Hepatobiliary & Liver Transplantat Surg, Paris, France | |
hcfmusp.author.external | LANGELLA, Serena:Osped Mauriziano Umberto 1, Dept Gen & Oncol Surg, Turin, Italy | |
hcfmusp.author.external | KAWAI, Takayuki:Kyoto Univ, Grad Sch Med, Dept Surg, Kyoto, Japan | |
hcfmusp.author.external | SCHIELKE, Astrid:CHU Liege CHU ULg, Dept Abdominal Surg & Transplantat, Liege, Belgium | |
hcfmusp.author.external | COLLI, Fabio:AOU Citta Salute & Sci Torino, Liver Transplant Unit, Gen Surg 2U, Turin, Italy | |
hcfmusp.author.external | RESENDE, Vivian:Univ Fed Minas Gerais, Dept Hepatobiliary & Liver Transplantat Surg, Belo Horizonte, MG, Brazil | |
hcfmusp.author.external | FLERES, Francesco:Robert Debre Univ Hosp, Dept Gen Digest & Endocrine Surg, Reims, France | |
hcfmusp.author.external | ROULIN, Didier:CHU Vaudois, Dept Hepatobiliary Surg, Lausanne, Switzerland | |
hcfmusp.author.external | LEYMAN, Paul:GZA Hosp, Dept Gen, Dept Gen & Digest Surg, Antwerp, Belgium | |
hcfmusp.author.external | GIACOMONI, Alessandro:Osped Niguarda Ca Granda, Div Gen HPB & Transplantat Surg, Milan, Italy | |
hcfmusp.author.external | GRANGER, Benjamin:Hop La Pitie Salpetriere, AP HP, Dept Biostat Publ Hlth & Med Informat, Paris, France | |
hcfmusp.author.external | FARTOUX, Laetitia:Hop La Pitie Salpetriere, AP HP, Dept Hepatobiliary & Liver Transplantat Surg, Paris, France | |
hcfmusp.author.external | CARLIS, Luciano De:Osped Niguarda Ca Granda, Div Gen HPB & Transplantat Surg, Milan, Italy | |
hcfmusp.author.external | DEMARTINES, Nicolas:CHU Vaudois, Dept Hepatobiliary Surg, Lausanne, Switzerland | |
hcfmusp.author.external | SOMMACALE, Daniele:Robert Debre Univ Hosp, Dept Gen Digest & Endocrine Surg, Reims, France | |
hcfmusp.author.external | SANCHES, Marcelo Dias:Univ Fed Minas Gerais, Dept Hepatobiliary & Liver Transplantat Surg, Belo Horizonte, MG, Brazil | |
hcfmusp.author.external | PATRONO, Damiano:AOU Citta Salute & Sci Torino, Liver Transplant Unit, Gen Surg 2U, Turin, Italy | |
hcfmusp.author.external | DETRY, Olivier:CHU Liege CHU ULg, Dept Abdominal Surg & Transplantat, Liege, Belgium | |
hcfmusp.author.external | OKUMURA, Shinya:Kyoto Univ, Grad Sch Med, Dept Surg, Kyoto, Japan | |
hcfmusp.author.external | FERRERO, Alessandro:Osped Mauriziano Umberto 1, Dept Gen & Oncol Surg, Turin, Italy | |
hcfmusp.author.external | SCATTON, Olivier:Hop La Pitie Salpetriere, AP HP, Dept Hepatobiliary & Liver Transplantat Surg, Paris, France | |
hcfmusp.description.beginpage | 560 | |
hcfmusp.description.endpage | 571 | |
hcfmusp.description.issue | 4 | |
hcfmusp.description.volume | 46 | |
hcfmusp.origem | WOS | |
hcfmusp.origem.id | WOS:000527364200012 | |
hcfmusp.origem.id | 2-s2.0-85075419516 | |
hcfmusp.publisher.city | OXFORD | eng |
hcfmusp.publisher.country | ENGLAND | eng |
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dc.description.index | MEDLINE | eng |
dc.identifier.eissn | 1532-2157 | |
hcfmusp.citation.scopus | 8 | - |
hcfmusp.scopus.lastupdate | 2024-03-29 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MGT Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/37 Artigos e Materiais de Revistas Científicas - ODS/03 |
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art_BRUSTIA_Preoperative_risk_score_for_prediction_of_longterm_outcomes_2020.PDF Restricted Access | publishedVersion (English) | 1.13 MB | Adobe PDF | View/Open Request a copy |
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