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Title: Genomic and Epidemiological Surveillance of Zika Virus in the Amazon Region
Authors: GIOVANETTI, MartaFARIA, Nuno RodriguesLOURENCO, JoseJESUS, Jaqueline Goes deXAVIER, JoilsonCLARO, Ingra MoralesKRAEMER, Moritz U. G.FONSECA, VagnerDELLICOUR, SimonTHEZE, JulienSALLES, Flavia da SilvaGRAF, TiagoSILVEIRA, Paola PazNASCIMENTO, Valdinete Alves doSOUZA, Victor Costa deIANI, Felipe Campos de MeloCASTILHO-MARTINS, Emerson AugustoCRUZ, Laura NogueiraWALLAU, GabrielFABRI, AllisonLEVY, FlaviaQUICK, JoshuaAZEVEDO, Vasco deAGUIAR, Renato SantanaOLIVEIRA, Tulio deMENEZES, Camila Botto deCASTILHO, Marcia da CostaTERRA, Tirza MatosSILVA, Marineide Souza daFILIPPIS, Ana Maria Bispo deABREU, Andre Luiz deOLIVEIRA, Wanderson KleberCRODA, JulioALBUQUERQUE, Carlos F. Campelo deNUNES, Marcio R. T.SABINO, Ester CerdeiraLOMAN, NicholasNAVECA, Felipe GomesPYBUS, Oliver G.ALCANTARA, Luiz Carlos
Citation: CELL REPORTS, v.30, n.7, p.2275-2283, 2020
Abstract: Zika virus (ZIKV) has caused an explosive epidemic linked to severe clinical outcomes in the Americas. As of June 2018, 4,929 ZIKV suspected infections and 46 congenital syndrome cases had been reported in Manaus, Amazonas, Brazil. Although Manaus is a key demographic hub in the Amazon region, little is known about the ZIKV epidemic there, in terms of both transmission and viral genetic diversity. Using portable virus genome sequencing, we generated 59 ZIKV genomes in Manaus. Phylogenetic analyses indicated multiple introductions of ZIKV from northeastern Brazil to Manaus. Spatial genomic analysis of virus movement among six areas in Manaus suggested that populous northern neighborhoods acted as sources of virus transmission to other neighborhoods. Our study revealed how the ZIKV epidemic was ignited and maintained within the largest urban metropolis in the Amazon. These results might contribute to improving the public health response to outbreaks in Brazil.
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Artigos e Materiais de Revistas Científicas - FM/MIP
Departamento de Moléstias Infecciosas e Parasitárias - FM/MIP

Artigos e Materiais de Revistas Científicas - LIM/46
LIM/46 - Laboratório de Parasitologia Médica

Artigos e Materiais de Revistas Científicas - ODS/03

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