Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/36018
Title: A Brazilian multicentre study evaluating pregnancies induced by cabergoline in patients harboring prolactinomas
Authors: ANNA, B. G. SantMUSOLINO, N. R. C.GADELHA, M. R.MARQUES, C.CASTRO, M.ELIAS, P. C. L.VILAR, L.LYRA, R.MARTINS, M. R. A.QUIDUTE, A. R. P.ABUCHAM, J.NAZATO, D.GARMES, H. M.FONTANA, M. L. C.BOGUSZEWSKI, C. L.BUENO, C. B.CZEPIELEWSKI, M. A.PORTES, E. S.NUNES-NOGUEIRA, V. S.RIBEIRO-OLIVEIRA, Jr. AV, R. P. FranciscoBRONSTEIN, M. D.GLEZER, A.
Citation: PITUITARY, v.23, n.2, p.120-128, 2020
Abstract: Objective To evaluate the maternal-fetal outcomes of CAB-induced pregnancies in patients with prolactinoma in a large cohort. Methods The prevalence of tumor growth, miscarriage, preterm, low birth weight, congenital malformations and impairment in neuropsychological development in children among women treated with CAB were assessed in a Brazilian multicentre retrospective observational study, Results We included 194 women with a mean age of 31 (17-45) years, 43.6% presenting microadenomas and 56.4% macroadenomas, at prolactinoma diagnosis. In 233 pregnancies, CAB was withdrawn in 89%, after pregnancy confirmation. Symptoms related to tumor growth occurred in 25 cases, more frequently in macroadenomas. The overall miscarriage rate was 11%, although higher in the subgroup of patients with CAB maintainance after pregnancy confirmation (38% vs. 7.5%). Amongst the live-birth deliveries, preterm occurred in 12%, low birth weight in 6% and congenital malformations in 4.3%. Neuropsychological development impairment was reported in 7% of cases. Conclusions Our findings confirm previous results of safety in maternal and fetal outcomes in CAB-induced pregnancies; nevertheless, CAB maintenance after pregnancy confirmation was associated with higher miscarriage rate; result that must be further confirmed.
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Artigos e Materiais de Revistas Científicas - FM/MOG
Departamento de Obstetrícia e Ginecologia - FM/MOG

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Instituto Central - HC/ICHC

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Instituto de Psiquiatria - HC/IPq

Artigos e Materiais de Revistas Científicas - LIM/25
LIM/25 - Laboratório de Endocrinologia Celular e Molecular

Artigos e Materiais de Revistas Científicas - LIM/57
LIM/57 - Laboratório de Fisiologia Obstétrica

Artigos e Materiais de Revistas Científicas - ODS/03
ODS/03 - Saúde e bem-estar


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