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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorANNA, B. G. Sant
dc.contributor.authorMUSOLINO, N. R. C.
dc.contributor.authorGADELHA, M. R.
dc.contributor.authorMARQUES, C.
dc.contributor.authorCASTRO, M.
dc.contributor.authorELIAS, P. C. L.
dc.contributor.authorVILAR, L.
dc.contributor.authorLYRA, R.
dc.contributor.authorMARTINS, M. R. A.
dc.contributor.authorQUIDUTE, A. R. P.
dc.contributor.authorABUCHAM, J.
dc.contributor.authorNAZATO, D.
dc.contributor.authorGARMES, H. M.
dc.contributor.authorFONTANA, M. L. C.
dc.contributor.authorBOGUSZEWSKI, C. L.
dc.contributor.authorBUENO, C. B.
dc.contributor.authorCZEPIELEWSKI, M. A.
dc.contributor.authorPORTES, E. S.
dc.contributor.authorNUNES-NOGUEIRA, V. S.
dc.contributor.authorRIBEIRO-OLIVEIRA, Jr. A
dc.contributor.authorV, R. P. Francisco
dc.contributor.authorBRONSTEIN, M. D.
dc.contributor.authorGLEZER, A.
dc.identifier.citationPITUITARY, v.23, n.2, p.120-128, 2020
dc.description.abstractObjective To evaluate the maternal-fetal outcomes of CAB-induced pregnancies in patients with prolactinoma in a large cohort. Methods The prevalence of tumor growth, miscarriage, preterm, low birth weight, congenital malformations and impairment in neuropsychological development in children among women treated with CAB were assessed in a Brazilian multicentre retrospective observational study, Results We included 194 women with a mean age of 31 (17-45) years, 43.6% presenting microadenomas and 56.4% macroadenomas, at prolactinoma diagnosis. In 233 pregnancies, CAB was withdrawn in 89%, after pregnancy confirmation. Symptoms related to tumor growth occurred in 25 cases, more frequently in macroadenomas. The overall miscarriage rate was 11%, although higher in the subgroup of patients with CAB maintainance after pregnancy confirmation (38% vs. 7.5%). Amongst the live-birth deliveries, preterm occurred in 12%, low birth weight in 6% and congenital malformations in 4.3%. Neuropsychological development impairment was reported in 7% of cases. Conclusions Our findings confirm previous results of safety in maternal and fetal outcomes in CAB-induced pregnancies; nevertheless, CAB maintenance after pregnancy confirmation was associated with higher miscarriage rate; result that must be further confirmed.eng
dc.subjectDopamine agonisteng
dc.subject.otherdopamine agonisteng
dc.subject.othertumor outcomeseng
dc.titleA Brazilian multicentre study evaluating pregnancies induced by cabergoline in patients harboring prolactinomaseng
dc.rights.holderCopyright SPRINGEReng
dc.subject.wosEndocrinology & Metabolismeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng, M. R.:Univ Fed Rio de Janeiro, Rio De Janeiro, RJ, Brazil, C.:Univ Fed Rio de Janeiro, Rio De Janeiro, RJ, Brazil, M.:Univ Sao Paulo, Med Sch Ribeirao Preto, Ribeirao Preto, SP, Brazil, P. C. L.:Univ Sao Paulo, Med Sch Ribeirao Preto, Ribeirao Preto, SP, Brazil, L.:Univ Fed Pernambuco, Recife, PE, Brazil, R.:Univ Fed Pernambuco, Recife, PE, Brazil, M. R. A.:Univ Fed Ceara, Fortaleza, Ceara, Brazil, A. R. P.:Univ Fed Ceara, Fortaleza, Ceara, Brazil, J.:Univ Fed Sao Paulo, Escola Paulista Med, Sao Paulo, SP, Brazil, D.:Univ Fed Sao Paulo, Escola Paulista Med, Sao Paulo, SP, Brazil, H. M.:Univ Estadual Campinas, Campinas, SP, Brazil, M. L. C.:Univ Estadual Campinas, Campinas, SP, Brazil, C. L.:Univ Fed Parana, Endocrine Div SEMPR, Dept Internal Med, Curitiba, Parana, Brazil, C. B.:Irmandade Santa Casa Misericordia Sao Paulo, Sao Paulo, SP, Brazil, M. A.:Hosp Clin Porto Alegre UFRGS, Div Endocrinol, Porto Alegre, RS, Brazil, E. S.:State Publ Hosp, Inst Med Assistance, Sao Paulo, SP, Brazil, V. S.:Sao Paulo State Univ UNESP, Med Sch, Botucatu, SP, Brazil, Jr. A:Univ Fed Minas Gerais, Belo Horizonte, MG, Brazil
hcfmusp.publisher.cityNEW YORKeng
hcfmusp.publisher.countryUNITED STATESeng
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Artigos e Materiais de Revistas Científicas - FM/MOG
Departamento de Obstetrícia e Ginecologia - FM/MOG

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - HC/IPq
Instituto de Psiquiatria - HC/IPq

Artigos e Materiais de Revistas Científicas - LIM/25
LIM/25 - Laboratório de Endocrinologia Celular e Molecular

Artigos e Materiais de Revistas Científicas - LIM/57
LIM/57 - Laboratório de Fisiologia Obstétrica

Artigos e Materiais de Revistas Científicas - ODS/03
ODS/03 - Saúde e bem-estar

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