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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorANNA, B. G. Sant
dc.contributor.authorMUSOLINO, N. R. C.
dc.contributor.authorGADELHA, M. R.
dc.contributor.authorMARQUES, C.
dc.contributor.authorCASTRO, M.
dc.contributor.authorELIAS, P. C. L.
dc.contributor.authorVILAR, L.
dc.contributor.authorLYRA, R.
dc.contributor.authorMARTINS, M. R. A.
dc.contributor.authorQUIDUTE, A. R. P.
dc.contributor.authorABUCHAM, J.
dc.contributor.authorNAZATO, D.
dc.contributor.authorGARMES, H. M.
dc.contributor.authorFONTANA, M. L. C.
dc.contributor.authorBOGUSZEWSKI, C. L.
dc.contributor.authorBUENO, C. B.
dc.contributor.authorCZEPIELEWSKI, M. A.
dc.contributor.authorPORTES, E. S.
dc.contributor.authorNUNES-NOGUEIRA, V. S.
dc.contributor.authorRIBEIRO-OLIVEIRA, Jr. A
dc.contributor.authorV, R. P. Francisco
dc.contributor.authorBRONSTEIN, M. D.
dc.contributor.authorGLEZER, A.
dc.date.accessioned2020-06-01T14:54:28Z-
dc.date.available2020-06-01T14:54:28Z-
dc.date.issued2020
dc.identifier.citationPITUITARY, v.23, n.2, p.120-128, 2020
dc.identifier.issn1386-341X
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/36018-
dc.description.abstractObjective To evaluate the maternal-fetal outcomes of CAB-induced pregnancies in patients with prolactinoma in a large cohort. Methods The prevalence of tumor growth, miscarriage, preterm, low birth weight, congenital malformations and impairment in neuropsychological development in children among women treated with CAB were assessed in a Brazilian multicentre retrospective observational study, Results We included 194 women with a mean age of 31 (17-45) years, 43.6% presenting microadenomas and 56.4% macroadenomas, at prolactinoma diagnosis. In 233 pregnancies, CAB was withdrawn in 89%, after pregnancy confirmation. Symptoms related to tumor growth occurred in 25 cases, more frequently in macroadenomas. The overall miscarriage rate was 11%, although higher in the subgroup of patients with CAB maintainance after pregnancy confirmation (38% vs. 7.5%). Amongst the live-birth deliveries, preterm occurred in 12%, low birth weight in 6% and congenital malformations in 4.3%. Neuropsychological development impairment was reported in 7% of cases. Conclusions Our findings confirm previous results of safety in maternal and fetal outcomes in CAB-induced pregnancies; nevertheless, CAB maintenance after pregnancy confirmation was associated with higher miscarriage rate; result that must be further confirmed.eng
dc.language.isoeng
dc.publisherSPRINGEReng
dc.relation.ispartofPituitary
dc.rightsrestrictedAccesseng
dc.subjectProlactinomaeng
dc.subjectPregnancyeng
dc.subjectDopamine agonisteng
dc.subjectCabergolineeng
dc.subjectMiscarriageeng
dc.subjectMalformationeng
dc.subject.otherpituitary-adenomaseng
dc.subject.otherdopamine agonisteng
dc.subject.othertumor outcomeseng
dc.subject.othergrowth-hormoneeng
dc.subject.otherwomeneng
dc.subject.otherbromocriptineeng
dc.subject.otherhyperprolactinemiaeng
dc.subject.otherlactationeng
dc.subject.othermanagementeng
dc.subject.otherglandeng
dc.titleA Brazilian multicentre study evaluating pregnancies induced by cabergoline in patients harboring prolactinomaseng
dc.typearticleeng
dc.rights.holderCopyright SPRINGEReng
dc.identifier.doi10.1007/s11102-019-01008-z
dc.identifier.pmid31728906
dc.subject.wosEndocrinology & Metabolismeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
hcfmusp.author.externalGADELHA, M. R.:Univ Fed Rio de Janeiro, Rio De Janeiro, RJ, Brazil
hcfmusp.author.externalMARQUES, C.:Univ Fed Rio de Janeiro, Rio De Janeiro, RJ, Brazil
hcfmusp.author.externalCASTRO, M.:Univ Sao Paulo, Med Sch Ribeirao Preto, Ribeirao Preto, SP, Brazil
hcfmusp.author.externalELIAS, P. C. L.:Univ Sao Paulo, Med Sch Ribeirao Preto, Ribeirao Preto, SP, Brazil
hcfmusp.author.externalVILAR, L.:Univ Fed Pernambuco, Recife, PE, Brazil
hcfmusp.author.externalLYRA, R.:Univ Fed Pernambuco, Recife, PE, Brazil
hcfmusp.author.externalMARTINS, M. R. A.:Univ Fed Ceara, Fortaleza, Ceara, Brazil
hcfmusp.author.externalQUIDUTE, A. R. P.:Univ Fed Ceara, Fortaleza, Ceara, Brazil
hcfmusp.author.externalABUCHAM, J.:Univ Fed Sao Paulo, Escola Paulista Med, Sao Paulo, SP, Brazil
hcfmusp.author.externalNAZATO, D.:Univ Fed Sao Paulo, Escola Paulista Med, Sao Paulo, SP, Brazil
hcfmusp.author.externalGARMES, H. M.:Univ Estadual Campinas, Campinas, SP, Brazil
hcfmusp.author.externalFONTANA, M. L. C.:Univ Estadual Campinas, Campinas, SP, Brazil
hcfmusp.author.externalBOGUSZEWSKI, C. L.:Univ Fed Parana, Endocrine Div SEMPR, Dept Internal Med, Curitiba, Parana, Brazil
hcfmusp.author.externalBUENO, C. B.:Irmandade Santa Casa Misericordia Sao Paulo, Sao Paulo, SP, Brazil
hcfmusp.author.externalCZEPIELEWSKI, M. A.:Hosp Clin Porto Alegre UFRGS, Div Endocrinol, Porto Alegre, RS, Brazil
hcfmusp.author.externalPORTES, E. S.:State Publ Hosp, Inst Med Assistance, Sao Paulo, SP, Brazil
hcfmusp.author.externalNUNES-NOGUEIRA, V. S.:Sao Paulo State Univ UNESP, Med Sch, Botucatu, SP, Brazil
hcfmusp.author.externalRIBEIRO-OLIVEIRA, Jr. A:Univ Fed Minas Gerais, Belo Horizonte, MG, Brazil
hcfmusp.description.beginpage120
hcfmusp.description.endpage128
hcfmusp.description.issue2
hcfmusp.description.volume23
hcfmusp.origemWOS
hcfmusp.origem.idWOS:000519161400005
hcfmusp.origem.id2-s2.0-85075050448
hcfmusp.publisher.cityNEW YORKeng
hcfmusp.publisher.countryUNITED STATESeng
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dc.description.indexMEDLINEeng
dc.identifier.eissn1573-7403
hcfmusp.citation.scopus9-
hcfmusp.scopus.lastupdate2022-06-03-
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