LIM/06 - Laboratório de Imunopatologia da Esquistossomose e outras Parasitoses

O Laboratório de Imunopatologia da Esquistossomose e outras Parasitoses é ligado ao Departamento de Doenças Infecciosas e Parasitárias da Faculdade de Medicina da Universidade de São Paulo (FMUSP).

Linhas de pesquisa: esquistossomose, toxocaríase, estrongiloidíase, blastocistose: epidemiologia, diagnóstico; leishmanioses; aspectos histopatológicos e estudo da resposta imune tecidual; AIDS: aspectos histopatológicos e estudo da compartimentalização da resposta imune; febres hemorrágicas: estudo da patogenia e técnicas diagnósticas; mucosa oral e neoplasias dermatológicas: estudos morfológicos e moleculares; leptospirose: patologia renal; hepatites autoimunes, virais e hepatopatias metabólicas.

Site oficial: http://limhc.fm.usp.br/portal/lim06-laboratorio-de-imunopatologia-da-esquistossomose-e-outras-parasitoses/

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Recent Submissions

  1. Expression patterns of Interleukin-33 and its receptor ST2 in severe COVID-19

    EUROPEAN RESPIRATORY JOURNAL, v.62, suppl.67, article ID OA2489, 2p, 2023

  2. Lung ECM composition, its influence factors and transcriptomics in the lungs of severe COVID-19.

    EUROPEAN RESPIRATORY JOURNAL, v.62, suppl.67, article ID PA5250, 2p, 2023

  3. microRNAs associated with metastatic potential in salivary gland mucoepidermoid carcinoma

    CANCER RESEARCH, v.83, n.7, suppl.S, 2023

  4. Enhancing the antischistosomal activity of carvacryl acetate using nanoemulsion

    NANOMEDICINE, v.18, n.4, p.331-342, 2023

    Aim: To formulate a carvacryl acetate nanoemulsion (CANE) and test its antischistosomal activity. Materials & methods: CANE was prepared and tested in vitro on Schistosoma mansoni adult worms and both human and animal cell lines. Next, CANE was administered orally to mice infected with either a p...

  5. COVID-19: detection methods in post-mortem samples

    PATHOLOGICA, v.115, n.5, p.263-274, 2023

    COVID-19 identification is routinely performed on fresh samples, such as nasopharyngeal and oropharyngeal swabs, even if, the detection of the virus in formalin-fixed paraffinembedded (FFPE) autopsy tissues could help to underlie mechanisms of the pathogenesis that are not well understood. The go...

  6. Monkeypox Virus Immune Evasion and Eye Manifestation: Beyond Eyelid Implications

    VIRUSES-BASEL, v.15, n.12, article ID 2301, 20p, 2023

    Monkeypox virus (MPXV), belonging to the Poxviridae family and Orthopoxvirus genus, is closely related to the smallpox virus. Initial prodromal symptoms typically include headache, fever, and lymphadenopathy. This review aims to detail various ocular manifestations and immune evasion associated w...

  7. Immunohistochemical Characterization of M1, M2, and M4 Macrophages in Leprosy Skin Lesions

    PATHOGENS, v.12, n.10, article ID 1225, 14p, 2023

    Mycobacterium leprae is the etiological agent of leprosy. Macrophages (M phi s) are key players involved in the pathogenesis of leprosy. In this study, immunohistochemical analysis was performed to examine the phenotype of M phi subpopulations, namely M1, M2, and M4, in the skin lesions of patien...

  8. Intranasal Liposomal Formulation of Spike Protein Adjuvanted with CpG Protects and Boosts Heterologous Immunity of hACE2 Transgenic Mice to SARS-CoV-2 Infection

    VACCINES, v.11, n.11, article ID 1732, 17p, 2023

    Mucosal vaccination appears to be suitable to protect against SARS-CoV-2 infection. In this study, we tested an intranasal mucosal vaccine candidate for COVID-19 that consisted of a cationic liposome containing a trimeric SARS-CoV-2 spike protein and CpG-ODNs, a Toll-like receptor 9 agonist, as a...

  9. Strongyloides infection screening in transplant candidates: What is the best strategy?

    TRANSPLANT INFECTIOUS DISEASE, v.25, n.6, 2023

    Background: The potential that Strongyloides stercoralis infection has to cause major morbidity and high mortality when the disseminated form occurs in transplant patients is of particular concern.Methods: In this study, the objective was to observe S. stercoralis infection in patients who are ca...

  10. Transcriptome analysis of six tissues obtained post-mortem from sepsis patients

    JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, v.27, n.20, p.3157-3167, 2023

    Septic shock is a life-threatening clinical condition characterized by a robust immune inflammatory response to disseminated infection. Little is known about its impact on the transcriptome of distinct human tissues. To address this, we performed RNA sequencing of samples from the prefrontal cort...