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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorCOSTA, Larissa R.
dc.contributor.authorCARVALHO, Aluizio B.
dc.contributor.authorBITTENCOURT, Amandha L.
dc.contributor.authorROCHITTE, Carlos E.
dc.contributor.authorCANZIANI, Maria Eugenia F.
dc.identifier.citationBMC NEPHROLOGY, v.21, n.1, article ID 121, 7p, 2020
dc.description.abstractBackground Vascular calcification progression has been associated with the loss of trabecular bone in chronic kidney disease (CKD) patients. There are few data evaluating the relationship between cortical bone loss and vascular calcification in this population. The aim of this study was to prospectively evaluate the association between changes in cortical bone density and coronary artery calcification (CAC) progression in non-dialyzed CKD patients. Methods Changes of cortical and trabecular bone, and changes of calcium score, were analyzed using vertebral tomographic images from a prospective study. Automatic delineation of the cortical bone layer was performed by Image J software, and trabecular bone was determined by selecting a region of interest using Vitrea 2 (R) software. Cortical and trabecular bone density (BD) were expressed in Hounsfield Units (HU), and coronary artery calcium score in Agatston Units (AU). Results Seventy asymptomatic patients [57.8 +/- 10.2 years, 63% males, 20% diabetic, estimated glomerular filtration rate (eGFR) = 37.3 (24.8-51.3) mL/min/1.73m(2)] were followed for 24 months. The mean cortical and trabecular BD did not change over time. While 49 patients lost either bone, 29 (41%) patients lost cortical [- 4.4%/year (ranging from - 7.15 to - 0.5)] and 39 (56%) lost trabecular bone [- 3.15%/year (- 13.7 to - 0.25)]. There was no association between cortical and trabecular BD changes (p = 0.12). CAC was observed in 33 (46%) patients at baseline, and 30 (91%) of them showed CAC progression. While an inverse correlation between trabecular bone and calcium score changes was observed (p = 0.001), there was no correlation between cortical bone and calcium score changes (p = 0.34). Conclusion CKD patients experience either cortical or trabecular bone loss over time, but these changes do not take place simultaneously in all patients. Cortical, unlike trabecular bone loss, is not associated with vascular calcification progression in these patients.eng
dc.description.sponsorshipCNPq, Conselho Nacional de Desenvolvimento Cientifico e TecnologicoNational Council for Scientific and Technological Development (CNPq)
dc.relation.ispartofBMC Nephrology
dc.subjectCortical boneeng
dc.subjectTrabecular boneeng
dc.subjectVascular calcificationeng
dc.subjectChronic kidney diseaseeng
dc.subject.othercoronary-artery calcificationeng
dc.subject.otherquantitative computed-tomographyeng
dc.subject.otherx-ray absorptiometryeng
dc.subject.othermineral densityeng
dc.titleCortical unlike trabecular bone loss is not associated with vascular calcification progression in CKD patientseng
dc.rights.holderCopyright BMCeng
dc.subject.wosUrology & Nephrologyeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng, Larissa R.:Univ Fed Sao Paulo, Nephrol Div, Rua Pedro de Toledo,282 Vila Clementino, BR-04039000 Sao Paulo, SP, Brazil, Aluizio B.:Univ Fed Sao Paulo, Nephrol Div, Rua Pedro de Toledo,282 Vila Clementino, BR-04039000 Sao Paulo, SP, Brazil, Amandha L.:Univ Fed Sao Paulo, Nephrol Div, Rua Pedro de Toledo,282 Vila Clementino, BR-04039000 Sao Paulo, SP, Brazil, Maria Eugenia F.:Univ Fed Sao Paulo, Nephrol Div, Rua Pedro de Toledo,282 Vila Clementino, BR-04039000 Sao Paulo, SP, Brazil
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ODS/03 - Saúde e bem-estar

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