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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorMARANHAO, Raul C.
dc.contributor.authorPALA, Daniela
dc.contributor.authorFREITAS, Fatima R.
dc.identifier.citationCURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY, v.27, n.2, p.104-109, 2020
dc.description.abstractPurpose of review The speed of removal from the plasma of apolipoprotein B-containing lipoproteins, for example, chylomicrons, VLDL and LDL is determinant of the plasma concentration of these lipoproteins, is influenced by genetic features and ambient factors, and has implications in atherogenesis. As aging increases the clinical complications of atherosclerosis, it is important to appraise the status of the removal mechanisms in elderly individuals. Recent findings Removal of triglyceride-rich lipoproteins remnants is delayed but the triglyceride breakdown is unchanged in elderly individuals. The discovery of PCSK9, enzyme that degrades LDL receptors, and the recent observation that PCSK9 is elevated in the elderly raises another hypothesis to account for the increased LDL-cholesterol levels in the elderly. The removal of cholesterol from cells by HDL, the first step of cholesterol reverse transport is also less efficient in the elderly, which may compromise the body cholesterol homeostasis. Aging determines reduction of the efficiency of lipoprotein plasma removal mechanisms, which is implicated in increased incidence of cardia complications. Moreover, aging is frequently accompanied by physical activity reduction, weight gain, and metabolic disturbances that can further decrease the efficacy of the removal mechanisms. This knowledge is important for promoting cardiovascular health in the elderly and prolonging survival.eng
dc.description.sponsorshipSao Paulo Research Foundation (Fapesp, Brazil)Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
dc.description.sponsorshipNational Institute of Science and Technology Complex Fluids (INCT-FCx, Brazil)
dc.description.sponsorshipNational Council for Scientific and Technological Development (CNPq, Brasilia, Brazil)National Council for Scientific and Technological Development (CNPq)
dc.relation.ispartofCurrent Opinion in Endocrinology Diabetes and Obesity
dc.subjectlow-density lipoprotein receptors and agingeng
dc.subjectlipoprotein kineticseng
dc.subject.otherchylomicron-like emulsioneng
dc.subject.othersubtilisin/kexin type 9eng
dc.subject.otherdisease risk-factorseng
dc.subject.otherall-cause mortalityeng
dc.subject.otherplasma kineticseng
dc.subject.othertotal cholesteroleng
dc.titleLipoprotein removal mechanisms and aging: implications for the cardiovascular health of the elderlyeng
dc.rights.holderCopyright LIPPINCOTT WILLIAMS & WILKINSeng
dc.subject.wosEndocrinology & Metabolismeng
dc.type.versionpublishedVersioneng, Daniela:Univ Sao Paulo, Hosp Clin HCFMUSP, Inst Coracao InCor, Fac Med, Av Dr Eneas de Carvalho Aguiar,44 Bloco 2, BR-05403000 Sao Paulo, Brazil
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