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https://observatorio.fm.usp.br/handle/OPI/36290
Title: | Psychotic and affective symptoms of early-onset bipolar disorder: an observational study of patients in first manic episode |
Authors: | FU-I, Lee; GURGEL, Wagner de S.; CAETANO, Sheila C.; MACHADO-VIEIRA, Rodrigo; WANG, Yuan P. |
Citation: | BRAZILIAN JOURNAL OF PSYCHIATRY, v.42, n.2, p.168-174, 2020 |
Abstract: | Objective: Presence of psychotic symptoms seems to be a commonplace in early-onset bipolar disorder (BD). However, few studies have examined their occurrence in adolescent-onset BD. We sought to investigate the frequency of affective and psychotic symptoms observed during the first manic episode in adolescents. Methods: Forty-nine adolescents with bipolar I disorder (DSM-IV criteria) were admitted to a psychiatric hospital during their first acute manic episode. Assessment for current psychiatric diagnosis was performed by direct clinical interview and the DSM-IV version of the Diagnostic Interview for Children and Adolescents (DICA). Results: Teenage inpatients with BD consistently exhibited typical manic features, such as euphoria, grandiosity, and psychomotor agitation. In addition, disorganization and psychotic symptoms were present in 82 and 55% of the total sample, respectively. There was no significant difference in symptoms between early- and late-adolescent subgroups. Remarkably, most patients (76%) reported previous depressive episode(s); of these, 47% had prominent psychotic features in the prior depressive period. Conclusion: These findings suggest that disorganization and psychotic symptoms during the first manic episode are salient features in adolescent-onset BD, and that psychotic depression frequently may precede psychotic mania. Nevertheless, differential diagnosis with schizophrenia should be routinely ruled out in cases of early-onset first psychotic episode. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - HC/IPq Artigos e Materiais de Revistas Científicas - LIM/23 |
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art_FU-I_Psychotic_and_affective_symptoms_of_earlyonset_bipolar_disorder_2020.PDF | publishedVersion (English) | 124.4 kB | Adobe PDF | View/Open |
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