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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | |
dc.contributor.author | RAUCHMANN, Boris-Stephan | |
dc.contributor.author | GHASEMINEJAD, Farhad | |
dc.contributor.author | KEESER, Daniel | |
dc.contributor.author | KELLER-VARADY, Katriona | |
dc.contributor.author | SCHNEIDER-AXMANN, Thomas | |
dc.contributor.author | TAKAHASHI, Shun | |
dc.contributor.author | KARALI, Temmuz | |
dc.contributor.author | HELMS, Gunther | |
dc.contributor.author | DECHENT, Peter | |
dc.contributor.author | MAURUS, Isabel | |
dc.contributor.author | HASAN, Alkomiet | |
dc.contributor.author | WOBROCK, Thomas | |
dc.contributor.author | ERTL-WAGNER, Birgit | |
dc.contributor.author | SCHMITT, Andrea | |
dc.contributor.author | MALCHOW, Berend | |
dc.contributor.author | FALKAI, Peter | |
dc.date.accessioned | 2020-06-01T15:06:34Z | - |
dc.date.available | 2020-06-01T15:06:34Z | - |
dc.date.issued | 2020 | |
dc.identifier.citation | BRAIN IMAGING AND BEHAVIOR, v.14, n.2, p.515-526, 2020 | |
dc.identifier.issn | 1931-7557 | |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/36304 | - |
dc.description.abstract | Higher glutamate and glutamine (together: Glx) and lower N-acetyl-aspartate (NAA) levels were reported in schizophrenia. Endurance training normalizes NAA in the hippocampus, but its effects on other metabolites in the brain and the relationship of metabolites to clinical symptoms remain unknown. For 12 weeks, 20 schizophrenia inpatients (14 men, 6 women) and 23 healthy controls (16 men, 7 women) performed endurance training and a control group of 21 schizophrenia inpatients (15 men, 6 women) played table soccer. A computer-assisted cognitive performance training program was introduced after 6 weeks. We assessed cognitive performance, psychopathological symptoms, and everyday functioning at baseline and after 6 and 12 weeks and performed single voxel magnetic resonance spectroscopy of the hippocampus, left dorsolateral prefrontal cortex (DLPFC), and thalamus. We quantified NAA, Glx, total creatine (tCr), calculated NAA/tCr and Glx/tCr and correlated these ratios with physical fitness, clinical and neurocognitive scores, and everyday functioning. At baseline, in both schizophrenia groups NAA/tCr was lower in the left DLPFC and left hippocampus and Glx/tCr was lower in the hippocampus than in the healthy controls. After 6 weeks, NAA/tCr increased in the left DLPFC in both schizophrenia groups. Brain metabolites did not change significantly in the hippocampus or thalamus, but the correlation between NAA/tCr and Glx/tCr normalized in the left DLPFC. Global Assessment of Functioning improvements correlated with NAA/tCr changes in the left DLPFC. In our study, endurance training and table soccer induced normalization of brain metabolite ratios in the brain circuitry associated with neuronal and synaptic elements, including metabolites of the glutamatergic system. | eng |
dc.description.sponsorship | Klinische Forschergruppe (KFO) 241 and PsyCourseGerman Research Foundation (DFG) [FA241/16-1] | |
dc.description.sponsorship | Deutsche Forschungsgemeinschaft (DFG)German Research Foundation (DFG) | |
dc.description.sponsorship | German Federal Ministry of Education and Research (BMBF) through the research network on psychiatric diseases ESPRITFederal Ministry of Education & Research (BMBF) [01EE1407E] | |
dc.language.iso | eng | |
dc.publisher | SPRINGER | eng |
dc.relation.ispartof | Brain Imaging and Behavior | |
dc.rights | restrictedAccess | eng |
dc.subject | Schizophrenia | eng |
dc.subject | MRS | eng |
dc.subject | Aerobic exercise | eng |
dc.subject | NAA | eng |
dc.subject | Glx | eng |
dc.subject | Clinical symptoms | eng |
dc.subject.other | magnetic-resonance-spectroscopy | eng |
dc.subject.other | n-acetyl-aspartate | eng |
dc.subject.other | prefrontal cortex | eng |
dc.subject.other | elderly-patients | eng |
dc.subject.other | glutamate | eng |
dc.subject.other | acetylaspartate | eng |
dc.subject.other | hippocampus | eng |
dc.subject.other | exercise | eng |
dc.subject.other | segmentation | eng |
dc.subject.other | plasticity | eng |
dc.title | The impact of endurance training and table soccer on brain metabolites in schizophrenia | eng |
dc.type | article | eng |
dc.rights.holder | Copyright SPRINGER | eng |
dc.identifier.doi | 10.1007/s11682-019-00198-1 | |
dc.identifier.pmid | 31686308 | |
dc.subject.wos | Neuroimaging | eng |
dc.type.category | original article | eng |
dc.type.version | publishedVersion | eng |
hcfmusp.author.external | RAUCHMANN, Boris-Stephan:Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Radiol, Munich, Germany; Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Psychiat & Psychotherapy, Munich, Germany | |
hcfmusp.author.external | GHASEMINEJAD, Farhad:Univ British Columbia, Dept Psychiat, Vancouver, BC, Canada | |
hcfmusp.author.external | KEESER, Daniel:Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Radiol, Munich, Germany | |
hcfmusp.author.external | KELLER-VARADY, Katriona:Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Psychiat & Psychotherapy, Munich, Germany | |
hcfmusp.author.external | SCHNEIDER-AXMANN, Thomas:Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Psychiat & Psychotherapy, Munich, Germany | |
hcfmusp.author.external | TAKAHASHI, Shun:Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Psychiat & Psychotherapy, Munich, Germany; Wakayama Med Univ, Dept Neuropsychiat, Wakayama, Japan | |
hcfmusp.author.external | KARALI, Temmuz:Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Psychiat & Psychotherapy, Munich, Germany | |
hcfmusp.author.external | HELMS, Gunther:Lund Univ, Dept Clin Sci Lund, Med Radiat Phys, Lund, Sweden | |
hcfmusp.author.external | DECHENT, Peter:Univ Med Ctr Gottingen, Inst Cognit Neurol, MR Res Neurol & Psychiat, Gottingen, Germany | |
hcfmusp.author.external | MAURUS, Isabel:Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Psychiat & Psychotherapy, Munich, Germany | |
hcfmusp.author.external | HASAN, Alkomiet:Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Psychiat & Psychotherapy, Munich, Germany | |
hcfmusp.author.external | WOBROCK, Thomas:Georg August Univ Gottingen, Dept Psychiat & Psychotherapy, Gottingen, Germany | |
hcfmusp.author.external | ERTL-WAGNER, Birgit:Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Radiol, Munich, Germany; Univ Toronto, Hosp Sick Children, Dept Med Imaging, Toronto, ON, Canada | |
hcfmusp.author.external | MALCHOW, Berend:Univ Hosp Jena, Dept Psychiat & Psychotherapy, Jena, Germany | |
hcfmusp.author.external | FALKAI, Peter:Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Psychiat & Psychotherapy, Munich, Germany | |
hcfmusp.description.beginpage | 515 | |
hcfmusp.description.endpage | 526 | |
hcfmusp.description.issue | 2 | |
hcfmusp.description.volume | 14 | |
hcfmusp.origem | WOS | |
hcfmusp.origem.id | WOS:000494003100001 | |
hcfmusp.origem.id | 2-s2.0-85074827819 | |
hcfmusp.publisher.city | NEW YORK | eng |
hcfmusp.publisher.country | UNITED STATES | eng |
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dc.description.index | MEDLINE | eng |
dc.identifier.eissn | 1931-7565 | |
hcfmusp.citation.scopus | 5 | - |
hcfmusp.scopus.lastupdate | 2024-03-29 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - LIM/27 |
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