LIM/10 - Laboratório de Lípides

O Laboratório de Lípides é ligado ao Departamento de Clínica Médica da Faculdade de Medicina da Universidade de São Paulo (FMUSP).

Linhas de pesquisa: investigação do metabolismo de lípedes e lipoproteínas, com ênfase no transporte reverso de colesterol, nas dislipidemias, diabetes mellitus, inflamação e intervenções em estilo de vida (dieta e exercício físico), em humanos e modelos de aterosclerose experimental.

Site oficial: http://limhc.fm.usp.br/portal/lim10-laboratorio-de-lipides/

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Recent Submissions

  1. Cardiac Autonomic Neuropathy (CAN) and HDL Proteomics in Type 1 Diabetes (T1D)

    DIABETES, v.70, suppl.1, 2021

  2. Proposal of an obesity classification based on weight history: an official document by the Brazilian Society of Endocrinology and Metabolism (SBEM) and the Brazilian Society for the Study of Obesity and Metabolic Syndrome (ABESO)

    ARCHIVES OF ENDOCRINOLOGY METABOLISM, v.66, n.2, 2022

    Obesity is a chronic disease associated with impaired physical and mental health. A widespread view in the treatment of obesity is that the goal is to normalize the individual's body mass index (BMI). However, a modest weight loss (usually above 5%) is already associated with clinical improvement...

  3. The Plasma Distribution of Non-cholesterol Sterol Precursors and Products of Cholesterol Synthesis and Phytosterols Depend on HDL Concentration

    FRONTIERS IN NUTRITION, v.9, article ID 723555, 8p, 2022

    Non-cholesterol sterols are transported in plasma lipoproteins and are consequently important in cholesterol metabolism. We investigated the distribution of non-cholesterol sterol precursors of cholesterol synthesis (NCSPCS), oxysterols, and phytosterols in lipoproteins of healthy subjects differ...

  4. Plasma lathosterol measures rates of cholesterol synthesis and efficiency of dietary phytosterols in reducing the plasma cholesterol concentration

    CLINICS, v.77, article ID 100028, 6p, 2022

    Objectives: Because the plasma campesterol/cholesterol ratio does not differ between groups that absorb different amounts of cholesterol, the authors investigated whether the plasma Phytosterols (PS) relate to the body's cholesterol synthesis rate measured as non-cholesterol sterol precursors (la...

  5. Plasma advanced glycation end products and soluble receptor for advanced glycation end products as indicators of sterol content in human carotid atherosclerotic plaques

    DIABETES & VASCULAR DISEASE RESEARCH, v.19, n.1, article ID 14791641221085200, 9p, 2022

    Advanced glycation end products (AGEs) are independently related to cardiovascular disease (CVD) and favor cholesterol and oxysterol accumulation in macrophage foam cells. Soluble RAGE (sRAGE) impairs cellular AGE signaling alleviating the deleterious effects of AGE in atherogenesis. The associat...

  6. Advanced Glycation End Products: A Sweet Flavor That Embitters Cardiovascular Disease

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.23, n.5, article ID 2404, 17p, 2022

    Epidemiological studies demonstrate the role of early and intensive glycemic control in the prevention of micro and macrovascular disease in both type 1 and type 2 diabetes mellitus (DM). Hyperglycemia elicits several pathways related to the etiopathogenesis of cardiovascular disease (CVD), inclu...

  7. Cholesterol metabolism in aging simultaneously altered in liver and nervous system

    AGING-US, v.14, n.3, p.1549-1561, 2022

    In humans, aging, triggers increased plasma concentrations of triglycerides, cholesterol, low-density lipoproteins and lower capacity of high-density lipoproteins to remove cellular cholesterol. Studies in rodents showed that aging led to cholesterol accumulation in the liver and decrease in the ...

  8. LOW-SODIUM DIET INCREASES INSULIN RESISTANCE AND FAVORS FAT ACCUMULATION IN THE LIVER OF LDL RECEPTOR KNOCKOUT MICE

    ATHEROSCLEROSIS, v.315, p.E100-E100, 2020

  9. SKIN AUTOFLUORESCENCE AS AN INDICATOR OF SUBCLINICAL ATHEROSCLEROSIS IN OBESE ADULTS

    ATHEROSCLEROSIS, v.315, p.E72-E73, 2020

  10. N-acetylcystein Reduces Lipid Peroxidation and Advanced Glycation Related to Prevention of Macrophage Endoplasmic Reticulum Stress Induced by Albumin Isolated from Rats With Chronic Kidney Disease

    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, v.34, suppl.1, 2014