LIM/10 - Laboratório de Lípides

O Laboratório de Lípides é ligado ao Departamento de Clínica Médica da Faculdade de Medicina da Universidade de São Paulo (FMUSP).

Linhas de pesquisa: investigação do metabolismo de lípedes e lipoproteínas, com ênfase no transporte reverso de colesterol, nas dislipidemias, diabetes mellitus, inflamação e intervenções em estilo de vida (dieta e exercício físico), em humanos e modelos de aterosclerose experimental.

Site oficial: http://limhc.fm.usp.br/portal/lim10-laboratorio-de-lipides/

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Recent Submissions

  1. Persistent Effect of Advanced Glycated Albumin Driving Inflammation and Disturbances in Cholesterol Efflux in Macrophages

    NUTRIENTS, v.13, n.10, article ID 3633, 20p, 2021

    Advanced glycated albumin (AGE-albumin) impairs cholesterol efflux and contributes to inflammation in macrophages. The current study evaluated: (1) the persistence of the deleterious effect of AGE-albumin in cholesterol efflux and in inflammation, and (2) how metabolic control in diabetes mellitu...

  2. Update of the Brazilian Guideline for Familial Hypercholesterolemia-2021

    ARQUIVOS BRASILEIROS DE CARDIOLOGIA, v.117, n.4, p.782-842, 2021

  3. POST-IMMUNIZATION WITH COLLAGEN V CONFERS A DISADVANTAGEOUS IMMUNE MATRICES MICROENVIRONMENT FOR EARLY LUNG FIBROSIS IN A SSc MOUSE MODEL

    ANNALS OF THE RHEUMATIC DISEASES, v.80, suppl.1, p.444-445, 2021

  4. CHOLESTEROL ESTER TRANSFER PROTEIN (CETP) EXPRESSION IN MICE PROMOTES CONTROL OF EXPERIMENTAL CUTANEOUS LEISHMANIASIS

    ATHEROSCLEROSIS, v.331, p.E139-E140, 2021

  5. AEROBIC EXERCISE TRAINING REDUCES INSULIN RESISTANCE AND ATHEROGENESIS INDUCED BY LOW-SODIUM DIET IN LDL RECEPTOR KNOCKOUT MICE

    ATHEROSCLEROSIS, v.331, p.E102-E103, 2021

  6. Thyroid collision tumor containing oncocytic carcinoma, classical and hobnail variants of papillary carcinoma and areas of poorly differentiated carcinoma

    ARCHIVES OF ENDOCRINOLOGY METABOLISM, v.65, n.4, p.495-499, 2021

    Collision tumors are rare and may comprise components with different behavior, treatments, and prognosis. We report an unprecedented case of aggressive thyroid collision tumor containing widely invasive oncocytic carcinoma (OC), classical and hobnail (HPTC) variants of papillary carcinoma, and po...

  7. Dietary sodium restriction alters muscle lipidomics that relates to insulin resistance in mice

    JOURNAL OF BIOLOGICAL CHEMISTRY, v.296, article ID 100344, 12p, 2021

    A low-sodium (LS) diet has been shown to reduce blood pressure (BP) and the incidence of cardiovascular diseases. However, severe dietary sodium restriction promotes insulin resistance (IR) and dyslipidemia in animal models and humans. Thus, further clarification of the long-term consequences of ...

  8. Cholesterol-Ester Transfer Protein Alters M1 and M2 Macrophage Polarization and Worsens Experimental Elastase-Induced Pulmonary Emphysema

    FRONTIERS IN IMMUNOLOGY, v.12, article ID 684076, 17p, 2021

    Cholesterol-ester transfer protein (CETP) plays a role in atherosclerosis, the inflammatory response to endotoxemia and in experimental and human sepsis. Functional alterations in lipoprotein (LP) metabolism and immune cell populations, including macrophages, occur during sepsis and may be relate...

  9. Letter by Quintao and Cazita Regarding Article, ""Inhibition of Cholesteryl Ester Transfer Protein Preserves High-Density Lipoprotein Cholesterol and Improves Survival in Sepsis""

    CIRCULATION, v.144, n.6, p.E120-E121, 2021

  10. Serum albumin modified by carbamoylation impairs macrophage cholesterol efflux in diabetic kidney disease

    JOURNAL OF DIABETES AND ITS COMPLICATIONS, v.35, n.9, article ID 107969, 8p, 2021

    Background and aims: Abnormalities in lipid metabolism, accumulation of uremic toxins and advanced glycation end products may contribute to worsening atherosclerosis. This study characterized the glycation and carbamoylation profile of serum albumin isolated from individuals with diabetic kidney ...