LIM/12 - Laboratório de Pesquisa Básica em Doenças Renais
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Renoprotective effect of N-acetylcysteine depends upon the severity of the ischemia reperfusion injury
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, v.54, n.11, article ID e9941, 8p, 2021
Acute kidney injury (AKI) is a common complication in seriously ill patients, while renal ischemia-reperfusion (I/R) injury is the most frequent event in this oxidative renal injury. N-acetylcysteine (NAC) is a small molecule containing a thiol group that has antioxidant properties, promoting det...
Renal thrombotic microangiopathy associated to worse renal prognosis in Lupus Nephritis
JOURNAL OF NEPHROLOGY, v.34, n.4, p.1147-1156, 2021
Introduction Renal thrombotic microangiopathy (rTMA) is one of many vascular findings in Lupus Nephritis (LN). However, the influence of rTMA on prognosis has not been well established. The objective of this study was to evaluate the clinical and pathological aspects of patients with lupus and rT...
Continuous renal replacement therapy in COVID-19-associated AKI: adding heparin to citrate to extend filter life-a retrospective cohort study
CRITICAL CARE, v.25, n.1, article ID 299, 13p, 2021
Background: Coronavirus disease 2019 (COVID-19) may predispose patients to thrombotic events. The best anticoagulation strategy for continuous renal replacement therapy (CRRT) in such patients is still under debate. The purpose of this study was to evaluate the impact that different anticoagulati...
Andrade, Lúcia. Insuficiência renal. In: Martins, Milton de Arruda; Quintino, Carla Romagnolli; Tibério, Iolanda de Fátima L. Calvo; Atta, José Antonio; Ivanovic, Lígia Fidelis (eds). Semiologia Clínica. SANTANA DE PARNAIBA: Manole, 2021. p.472-475.
Bonfá, Eloisa; Fuller, Ricardo; Pereira, Rosa Maria Rodrigues (eds). Reumatologia [2.ed.]. RIO DE JANEIRO: Atheneu, 2021. 333p.
Renal Inflammation and Innate Immune Activation Underlie the Transition From Gentamicin-Induced Acute Kidney Injury to Renal Fibrosis
FRONTIERS IN PHYSIOLOGY, v.12, article ID 606392, 11p, 2021
Subjects recovering from acute kidney injury (AKI) are at risk of developing chronic kidney disease (CKD). The mechanisms underlying this transition are unclear and may involve sustained activation of renal innate immunity, with resulting renal inflammation and fibrosis. We investigated whether t...
High blood pressure induced by vitamin D deficiency is associated with renal overexpression and hyperphosphorylation of Na+-K+-2Cl-cotransporter type 2
JOURNAL OF HYPERTENSION, v.39, n.5, p.880-891, 2021
Objectives: Clinical and epidemiological studies have suggested a correlation between vitamin D deficiency (VDD) and high blood pressure (BP). This study aimed to test the hypothesis that high BP induced by VDD is associated with altered expression and covalent modification of apical sodium trans...
The Restoration of Vitamin D Levels Slows the Progression of Renal Ischemic Injury in Rats Previously Deficient in Vitamin D
FRONTIERS IN MEDICINE, v.8, article ID 625647, 19p, 2021
Chronic kidney disease (CKD) remains a global public health problem. The initial damage after ischemia/reperfusion (I/R) injury plays an important role in the pathogenesis of acute kidney injury (AKI) and predisposition to CKD. Several studies have been showing that nontraditional risk factors su...
Changes in the renal function after acute mercuric chloride exposure in the rat are associated with renal vascular endothelial dysfunction and proximal tubule NHE3 inhibition
TOXICOLOGY LETTERS, v.341, p.23-32, 2021
Mercury is an environmental pollutant and a threat to human health. Mercuric chloride (HgCl2)-induced acute renal failure has been described by several reports, but the mechanisms of renal dysfunction remain elusive. This study tested the hypothesis that HgCl2 directly impairs renal vascular reac...
Green propolis extract attenuates acute kidney injury and lung injury in a rat model of sepsis
SCIENTIFIC REPORTS, v.11, n.1, article ID 5925, 11p, 2021
Sepsis is the leading cause of acute kidney injury (AKI) and lung injury worldwide. Despite therapeutic advances, sepsis continues to be associated with high mortality. Because Brazilian green propolis (GP) has promising anti-inflammatory, antioxidant, and immunomodulatory properties, we hypothes...