Coleções desta comunidade

Novos documentos depositados

1. Non-Alcoholic Fatty Liver Disease-Related Hepatocellular Carcinoma: Immunohistochemical Assessment of Markers of Cancer Cell Metabolism

   PATHOBIOLOGY, v.89, n.3, p.157-165, 2022

   Introduction: Hepatocellular carcinoma (HCC) has been associated to non-alcoholic fatty liver disease (NAFLD). We sought to investigate the immunoexpression of several glycolytic metabolism-associated markers in patients with HCC associated to NAFLD and associate these factors to their clinical-p...

2. Frequency of Human Papillomavirus Detection in Chagasic Megaesophagus Associated or Not with Esophageal Squamous Cell Carcinoma

   PATHOBIOLOGY, v.89, n.1, p.29-37, 2022

   Background: Chagasic megaesophagus (CM) as well as the presence of human papillomavirus (HPV) has been reported as etiological factors for esophageal squamous cell carcinoma (ESCC). Objective: We assessed the prevalence of HPV DNA in a series of ESCCs associated or not with CM. Data obtained were...

3. Combined Oral Contraceptive Use and the Risk of Cervical Cancer: Literature Review

   REVISTA BRASILEIRA DE GINECOLOGIA E OBSTETRICIA, v.45, n.12, p.E818-E823, 2023

   Cervical cancer (CC) is caused by persistent infection of human papillomavirus of high oncogenic risk (hr-HPV); however, several cofactors are important in its carcinogenesis, such as smoking, multiparity, and prolonged use of oral hormonal contraceptives (COCs). Worldwide, 16% of women use COCs,...

4. Effects of Lactate Transport Inhibition by AZD3965 in Muscle-Invasive Urothelial Bladder Cancer

   PHARMACEUTICS, v.15, n.12, article ID 2688, 21p, 2023

   The Warburg Effect is characterized by high rates of glucose uptake and lactate production. Monocarboxylate transporters (MCTs) are crucial to avoid cellular acidosis by internal lactate accumulation, being largely overexpressed by cancer cells and associated with cancer aggressiveness. The MCT1-...

5. Low EGFL7 expression is associated with high lymph node spread and invasion of lymphatic vessels in colorectal cancer

   SCIENTIFIC REPORTS, v.13, n.1, article ID 19783, 9p, 2023

   Studies indicate EGFL7 as an important gene in controlling angiogenesis and cancer growth, including in colorectal cancer (CRC). Anti-EGFL7 agents are being explored, yet without promising results. Therefore, the role of EGFL7 in CRC carcinogenesis should be investigated. This study aimed to eval...

6. Clinical Aspects and Etiologic Investigation of Pediatric Patients With Acute Liver Failure

   TRANSPLANTATION PROCEEDINGS, v.55, n.9, 2023

   A new outbreak of hepatitis of unknown origin raised awareness in the international community. A few reports have attempted to associate new cases with adenovirus infection and the immunologic effects of previous SARS-CoV-2 infections through a superantigen mechanism. Moreover, according to a cas...

7. Clinical and Prognostic Impact of the Warburg Effect in Esophageal Carcinoma: Monocarboxylate Transporters as Candidates for Therapeutic Targeting

   PATHOBIOLOGY, v.90, n.4, p.251-269, 2023

   Introduction: Esophageal cancer (EC) seems to display increased glycolytic activity, but clinical studies on the expression/prognostic significance of glycometabolism-related proteins, as well as functional assays, are missing. Methods: Expression of 10 glycolytic biomarkers was evaluated by immu...

8. Diaphragmatic hernia repair porcine model to compare the performance of biodegradable membranes against Gore-Tex®

   PEDIATRIC SURGERY INTERNATIONAL, v.40, n.1, article ID 7, 12p, 2023

   Background: Patch repair of congenital diaphragmatic hernia (CDH) using Gore-Tex (R) is associated with infection, adhesions, hernia recurrence, long-term musculoskeletal sequels and poor tissue regeneration. To overcome these limitations, the performance of two novel biodegradable membranes was ...

9. Exosomes modified with anti-MEK1 siRNA lead to an effective silencing of triple negative breast cancer cells

   BIOMATERIALS ADVANCES, v.154, article ID 213643, 13p, 2023

   Triple negative breast cancer (TNBC) is a highly heterogenous disease not sensitive to endocrine or HER2 therapy and standardized treatment regimens are still missing. Therefore, development of novel TNBC treatment approaches is of utmost relevance. Herein, the potential of MAPK/ERK downregulatio...

10. Gellan gum spongy-like hydrogel-based dual antibiotic therapy for infected diabetic wounds

    BIOENGINEERING & TRANSLATIONAL MEDICINE, v.8, n.3, 2023

    Diabetic foot infection (DFI) is an important cause of morbidity and mortality. Antibiotics are fundamental for treating DFI, although bacterial biofilm formation and associated pathophysiology can reduce their effectiveness. Additionally, antibiotics are often associated with adverse reactions. ...