LIM/16 - Laboratório de Fisiopatologia Renal

O Laboratório de Fisiopatologia Renal é ligado ao Departamento de Clínica Médica da Faculdade de Medicina da Universidade de São Paulo (FMUSP).

Linhas de pesquisa: hipertensão experimental: cloreto de sódio; nefropatias progressivas e doença óssea metabólica (osteodistrofia renal, osteoporose).

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Recent Submissions

  1. Hepatocyte Nuclear Factor 4 alpha is a novel osteoblast transcription factor that regulates osteogenesis and plays a role in ROD pathogenesis

    JOURNAL OF BONE AND MINERAL RESEARCH, v.38, suppl.1, p.4-4, 2023

  2. Effect of aluminum accumulation on bone and cardiovascular risk in the current era

    PLOS ONE, v.18, n.4, 2023

    BackgroundThe prevalence of aluminum (Al) intoxication has declined over the past 3 decades. However, different groups still report on the diagnosis of Al in bone. Prolonged and low-intensity exposures to Al may not be captured by serum Al measurements, preventing its proper diagnosis. We hypothe...

  3. Overview of renal osteodystrophy in Brazil: a cross-sectional study

    JORNAL BRASILEIRO DE NEFROLOGIA, v.45, n.2, p.257-261, 2023

    Introduction: The epidemiologic profile of renal osteodystrophy (ROD) is changing over time and cross-sectional studies provide essential information to improve care and health policies. The Brazilian Registry of Bone Biopsy (REBRABO) is a prospective, nationalmulticenter cohort that includes pat...

  4. International Perspectives on GFR Estimation and Race-Based Adjustments

    CLINICAL CHEMISTRY, v.69, n.8, p.796-802, 2023

  5. Chronic environmental hypoxia attenuates innate immunity activation and renal injury in two CKD models


    Tissue hypoxia has been pointed out as a major pathogenic factor in chronic kidney disease (CKD). However, epidemiological and experimental evidence inconsistent with this notion has been described. We have previously reported that chronic exposure to low ambient Po-2 promoted no renal injury in ...

  6. Bevacizumab-Associated Thrombotic Microangiopathy Treated with Eculizumab: A Case Report

    AMERICAN JOURNAL OF CASE REPORTS, v.24, article ID e940906, 7p, 2023

    Patient: Female, 64-year-old Final Diagnosis: Bevacizumab-associated thrombotic microangiopathy Symptoms: Microangiopathic hemolytic anemia and acute kidney injury Clinical Procedure: - Specialty: Nephrology Objective: Rare disease Background: Bevacizumab is an approved targeted therapy for metas...

  7. A Prospective Cross-Sectional Study on the Performance of the 2021 CKD-EPI Equations Without Race in a Multiracial Population of Adults With Solid Tumors in Brazil

    AMERICAN JOURNAL OF KIDNEY DISEASES, v.82, n.2, p.247-249, 2023

  8. In memoriam: Professor Gerhard Malnic

    JORNAL BRASILEIRO DE NEFROLOGIA, v.45, n.2, p.266-268, 2023

  9. Doença renal crônica

    Silva, Bruno Caldin da; Elias, Rosilene Motta. Doença renal crônica. In: Favarato, Maria Helena Sampaio; Saad, Rafael; Ivanovic, Lígia Fidelis; Jorge, Maria Cecília Pavanel; Oliveira, Júlio César de; Santos, Valter Garcia; Morinaga, Christian Valle; Bricola, Solange Aparecida Petilo de Carvalho; Nunes, Maria do Patrocínio Tenório; Martins, Mílton de Arruda (eds); Soeiro, Alexandre de Matos; Silva, Bruno Caldin da; Filadelfo, Cesar Ribeiro; Andrade, Daniel Ciampi de; Carvalho, Daniel Fiordelisio de; Nakagawa, Daniel Makoto; Sitnik, Debora; Colombo, Elisabetta Sachsida; Fonseca, Fabricio Lopes da; Lauterbach, Gerhard da Paz; Maesaka, Jonathan Yugo; Oliveira, Júlio César de; Ivanovic, Lígia Fidelis; Fonseca, Luciana Mazoti Lopes da; Gil Junior, Luiz Antonio; Marzinotto, Maira Andrade Nacimbem; Aun, Marcelo Vivolo; Vieira, Marcio Eduardo Bergamini; Jorge, Maria Cecília Pavanel; Nunes, Maria do Patrocínio Tenório; Favarato, Maria Helena Sampaio; D´Alessandro, Maria Perez Soares; Cordeiro, Maurício Dener; Mak, Milena Perez; Lima, Moisés da Cunha; Guidi, Paula Machado; Saad, Rafael; Teixeira, Ralcyon Francis Azevedo; Bricola, Solange Aparecida Petilo de Carvalho; Takahashi, Tiago Kenji; Santos, Valter Garcia; Cesar, Wagner G. Galvão; Nahas, William (coords). Manual do residente de clínica médica [3.ed.]. SANTANA DE PARNAÍBA: Manole, 2023. p.649-657.

  10. Transcription factor HNF4 & alpha;2 promotes osteogenesis and prevents bone abnormalities in mice with renal osteodystrophy

    JOURNAL OF CLINICAL INVESTIGATION, v.133, n.11, article ID e159928, 18p, 2023

    Renal osteodystrophy (ROD) is a disorder of bone metabolism that affects virtually all patients with chronic kidney disease (CKD) and is associated with adverse clinical outcomes including fractures, cardiovascular events, and death. In this study, we showed that hepatocyte nuclear factor 4 & alp...