LIM/16 - Laboratório de Fisiopatologia Renal

O Laboratório de Fisiopatologia Renal é ligado ao Departamento de Clínica Médica da Faculdade de Medicina da Universidade de São Paulo (FMUSP).

Linhas de pesquisa: hipertensão experimental: cloreto de sódio; nefropatias progressivas e doença óssea metabólica (osteodistrofia renal, osteoporose).

Site oficial: http://limhc.fm.usp.br/portal/lim16-laboratorio-de-fisiopatologia-renal/

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Recent Submissions

  1. Mixed uremic osteodystrophy: an ill-described common bone pathology in patients with chronic kidney disease

    OSTEOPOROSIS INTERNATIONAL, v.34, n.12, p.2003-2012, 2023

    Renal osteodystrophy (ROD) starts early and progresses with further loss of kidney function in patients with chronic kidney disease (CKD). There are four distinct types of ROD based on undecalcified bone biopsy results. Adynamic bone disease and osteomalacia are the predominant forms of low bone ...

  2. Evaluation of glomerular sirtuin-1 and claudin-1 in the pathophysiology of nondiabetic focal segmental glomerulosclerosis

    SCIENTIFIC REPORTS, v.13, n.1, article ID 22685, 14p, 2023

    Focal segmental glomerulosclerosis (FSGS) is the leading cause of nephrotic syndrome, which is characterized by podocyte injury. Given that the pathophysiology of nondiabetic glomerulosclerosis is poorly understood and targeted therapies to prevent glomerular disease are lacking, we decided to in...

  3. Remote vs. face-to-face activities in the teaching of renal pathophysiology in the context of social isolation during the early phase of the COVID-19 pandemic

    ADVANCES IN PHYSIOLOGY EDUCATION, v.47, n.4, p.788-795, 2023

    The advent of the COVID-19 pandemic forced medical schools around the world to adopt emergency remote learning as a resort to avoid interruption of courses. However, the effectiveness of online classes as an educational strategy has been questioned by medical educators and students. In a prospect...

  4. Effects of nutritional supplementation stabilizing muscle mass loss in older patients on hemodiafiltration

    CLINICAL NUTRITION ESPEN, v.58, p.97-103, 2023

    Background & aims: Malnutrition is common in older individuals with end-stage renal disease on maintenance dialysis. Whether nutritional supplementation may improve skeletal muscle mass (SMM) and survival rate in this population is uncertain. We aimed to analyze the effect of a year of nutritiona...

  5. Older patients are less prone to fast decline of renal function: a propensity-matched study

    INTERNATIONAL UROLOGY AND NEPHROLOGY, v.55, n.12, p.3245-3252, 2023

    PurposeDespite CKD is common among older patients, and although factors associated with CKD progression have been explored over decades, little is known about the decline of renal function specifically in older individuals.MethodsWe included adult patients with CKD on conservative management in a...

  6. Hepatocyte Nuclear Factor 4 alpha is a novel osteoblast transcription factor that regulates osteogenesis and plays a role in ROD pathogenesis

    JOURNAL OF BONE AND MINERAL RESEARCH, v.38, suppl.1, p.4-4, 2023

  7. Increased Expression of DKK-1 in an Adynamic Bone Disease Model: Role of Phosphate

    JOURNAL OF BONE AND MINERAL RESEARCH, v.38, suppl.1, p.227-227, 2023

  8. Chronic Kidney Disease-Associated Frailty is characterized by changes in Muscular Expression of RANKL and FNDC5, which are partially reverted after Parathyroidectomy

    JOURNAL OF BONE AND MINERAL RESEARCH, v.38, suppl.1, p.218-218, 2023

  9. Effect of aluminum accumulation on bone and cardiovascular risk in the current era

    PLOS ONE, v.18, n.4, 2023

    BackgroundThe prevalence of aluminum (Al) intoxication has declined over the past 3 decades. However, different groups still report on the diagnosis of Al in bone. Prolonged and low-intensity exposures to Al may not be captured by serum Al measurements, preventing its proper diagnosis. We hypothe...

  10. Overview of renal osteodystrophy in Brazil: a cross-sectional study

    JORNAL BRASILEIRO DE NEFROLOGIA, v.45, n.2, p.257-261, 2023

    Introduction: The epidemiologic profile of renal osteodystrophy (ROD) is changing over time and cross-sectional studies provide essential information to improve care and health policies. The Brazilian Registry of Bone Biopsy (REBRABO) is a prospective, nationalmulticenter cohort that includes pat...