LIM/17 - Laboratório de Investigação em Reumatologia

O Laboratório de Investigação em Reumatologia é ligado ao Departamento de Clínica Médica da Faculdade de Medicina da Universidade de São Paulo (FMUSP).

Linhas de pesquisa: autoimunidade e doenças reumatológicas; clínica, diagnóstico, coinfecção e tratamento da doença de Lyme no Brasil; matriz extracelular nas doenças difusas do tecido conjuntivo; modelo experimental de artrose e esclerodermia; fisiopatologia da resposta inflamatória; terapêutica nas artrites inflamatórias crônicas; osteoporose e doenças reumatológicas; biologia molecular e celular aplicada a doenças osteometabólicas; LES, vasculites e doença de Takayasu; medicina esportiva, coluna e doenças reumatológicas.

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Recent Submissions

  1. Characterization of refeeding protocols for under 18 years old hospitalized patients with anorexia nervosa: A systematic review

    GENERAL HOSPITAL PSYCHIATRY, v.85, p.43-54, 2023

    Purpose: To characterize and compare, through descriptive analysis, existing refeeding protocols for under 18 years old hospitalized patients with anorexia nervosa (AN). Methods: This is a systematic review of PubMed, Cochrane, SciELO, Lilacs and BVS databases, without search period restriction. ...

  2. Global comment on the use of hydroxychloroquine during the periconception period and pregnancy in women with autoimmune diseases

    LANCET RHEUMATOLOGY, v.5, n.9, p.e501-e506, 2023

  3. Pan American League of Associations for Rheumatology recommendations for the management of axial spondyloarthritis

    NATURE REVIEWS RHEUMATOLOGY, v.19, n.11, p.724-737, 2023

    Axial spondyloarthritis (axSpA) comprises a spectrum of chronic inflammatory manifestations affecting the axial skeleton and represents a challenge for diagnosis and treatment. Our objective was to generate a set of evidence-based recommendations for the management of axSpA for physicians, health...

  4. Erosion Identification in Metacarpophalangeal Joints in Rheumatoid Arthritis using High-Resolution Peripheral Quantitative Computed Tomography

    JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, n.200, article ID e65802, 17p, 2023

    Bone erosions are a pathological feature of several forms of inflammatory arthritis including rheumatoid arthritis (RA). The increased presence and size of erosions are associated with poor outcomes, joint function, and disease progression. High-resolution peripheral quantitative computed tomogra...

  5. Immune-Mediated Hypertrophic Pachymeningitis and its Mimickers: Magnetic Resonance Imaging Findings

    ACADEMIC RADIOLOGY, v.30, n.11, p.2696-2706, 2023

    Hypertrophic pachymeningitis (HP) is a rare and chronic inflammatory disorder presenting as localized or diffuse thickening of the dura mater. It can be idiopathic or an unusual manifestation of immune-mediated, infectious, and neoplastic conditions. Although some cases may remain asymptomatic, H...

  6. MicroRNA 205-5p and COVID-19 adverse outcomes: Potential molecular biomarker and regulator of the immune response

    EXPERIMENTAL BIOLOGY AND MEDICINE, v.248, n.12, p.1024-1033, 2023

    Coronavirus disease 2019 (COVID-19) is an acute respiratory infection caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The uncontrolled systemic inflammatory response, resulting from the release of large amounts of pro-inflammatory cytokines, is the main mechanism behin...

  7. Anserine is expressed in human cardiac and skeletal muscles

    PHYSIOLOGICAL REPORTS, v.11, n.19, article ID e15833, 8p, 2023

    We evaluated whether anserine, a methylated analog of the dipeptide carnosine, is present in the cardiac and skeletal muscles of humans and whether the CARNMT1 gene, which encodes the anserine synthesizing enzyme carnosine-N-methyltransferase, is expressed in human skeletal muscle. We found that ...

  8. Spit It Out: Is Caffeine Mouth Rinse an Effective Ergogenic Aid? A Systematic Review and Meta-Analysis

    STRENGTH AND CONDITIONING JOURNAL, v.45, n.5, p.617-627, 2023

    The effects of caffeine mouth rinse (Caff-MR) on sports performance have been evaluated by recent studies presenting contrasting results. Therefore, this systematic review aimed to summarize the evidence regarding the effects of Caff-MR on sports performance. According to Preferred Reporting Item...

  9. P1NP and β-CTX-1 Responses to a Prolonged, Continuous Running Bout in Young Healthy Adult Males: A Systematic Review with Individual Participant Data Meta-analysis

    SPORTS MEDICINE-OPEN, v.9, n.1, article ID 85, 16p, 2023

    Background Circulating biomarkers of bone formation and resorption are widely used in exercise metabolism research, but their responses to exercise are not clear. This study aimed to quantify group responses and inter-individual variability of P1NP and beta-CTX-1 after prolonged, continuous runni...

  10. Impact of switching between reference biologics and biosimilars of tumour necrosis factor inhibitors for rheumatoid arthritis: a systematic review and network meta-analysis

    SCIENTIFIC REPORTS, v.13, n.13699, 2023

    What is the impact of switching between biologics and biosimilars of adalimumab, etanercept, and infliximab on efficacy and safety for rheumatoid arthritis? A systematic review and network meta-analysis were performed to compare switching and non-switching groups of treatments. Pooled Risk Relati...