LIM/19 - Laboratório de Histocompatibilidade e Imunidade Celular

O Laboratório de Histocompatibilidade e Imunidade Celular é ligado ao Departamento de Cardiopneumologia da Faculdade de Medicina da Universidade de São Paulo (FMUSP).

Linhas de pesquisa: atuação focada no estudo do reconhecimento imunológico através do complexo trimolecular – molécula apresentadora (MHC), peptídeo e molécula de reconhecimento (LTCR) – e das consequências de tal reconhecimento, através de uma resposta de defesa ou de regulação; estuda como modelo as doenças do coração: febre reumática, Chagas ou aterosclerose e também o transplante de órgãos.

Site oficial:


Recent Submissions

  1. Basophil Activation Test as a Biomarker for Taxanes Anaphylaxis

    FRONTIERS IN ALLERGY, v.3, article ID 787749, 9p, 2022

    IntroductionTaxanes are widely used chemotherapy agents, and their administration, despite premedication, is associated with hypersensitivity reactions (HR) in up to 9% of patients, 1% of which are severe. The mechanisms of these reactions are not fully understood. Finding biomarkers for early di...

  2. Interview with Prof. Jorge Kalil: The Challenge of Doing Competitive Translational Research in Brazil


  3. Up-front Therapy With CHOP Plus Etoposide in Brazilian nodal PTCL Patients: Increased Toxicity and No Survival Benefit Compared to CHOP Regimen–Results of a Real-Life Study From a Middle-Income Country

    CLINICAL LYMPHOMA, MYELOMA AND LEUKEMIA, v.22, n.11, p.812-824, 2022

    Background: Nodal peripheral T-cell lymphoma (nPTCL) constitute a heterogeneous group of neoplasms with aggressive behavior and poor-survival. They are more prevalent in Latin America and Asia, although data from Brazil are scarce. Its primary therapy is still controversial and ineffective. There...

  4. Multicellular regulation of miR-196a-5p and miR-425-5 from adipose stem cell-derived exosomes and cardiac repair

    CLINICAL SCIENCE, v.136, n.17, p.1281-1301, 2022

    Cardiac transplantation of adipose-derived stem cells (ASC) modulates the post-myocardial infarction (post-MI) repair response. Biomolecules secreted or shuttled within extracellular vesicles, such as exosomes, may participate in the concerted response. We investigated the exosome’s microRNAs due...

  5. Time-dependent contraction of the SARS-CoV-2–specific T-cell responses in convalescent individuals


    Background: Adaptive immunity in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is decisive for disease control. Delayed activation of T cells is associated with a worse outcome in coronavirus disease 2019 (COVID-19). Although convalescent individuals exhibit solid T-cell ...

  6. Inflammatory cytokines and white matter microstructure in the acute phase of first-episode psychosis: A longitudinal study

    SCHIZOPHRENIA RESEARCH, v.257, p.5-18, 2023

    Objectives: Schizophrenia-related psychosis is associated with abnormalities in white matter (WM) microstructure and structural brain dysconnectivity. However, the pathological process underlying such changes is unknown. We sought to investigate the potential association between peripheral cytoki...

  7. MiRNA-30d and miR-770-5p as potential clinical risk predictors of Vasoplegic Syndrome in Patients undergoing on-pump coronary artery bypass grafting

    SCIENTIFIC REPORTS, v.13, n.1, 2023

    The aims of this study were to perform pre-surgery miRNA profiling of patients who develop Vasoplegic syndrome (VS) after coronary artery bypass grafting (CABG) and identify those miRNAs that could be used as VS prognostic tools and biomarkers. The levels of 754 microRNAs (miRNAs) were measured i...

  8. Cognitive impairment in long-COVID and its association with persistent dysregulation in inflammatory markers

    FRONTIERS IN IMMUNOLOGY, v.14, article ID 1174020, 13p, 2023

    ObjectiveTo analyze the potential impact of sociodemographic, clinical and biological factors on the long-term cognitive outcome of patients who survived moderate and severe forms of COVID-19. MethodsWe assessed 710 adult participants (Mean age = 55 +/- 14; 48.3% were female) 6 to 11 months after...

  9. Peri/epicellular Protein Disulfide Isomerase Reshapes Vascular Architecture to Counteracts Constrictive Remodeling

    FREE RADICAL BIOLOGY AND MEDICINE, v.76, suppl.1, p.S54-S54, 2014

  10. Peri/epicellular protein disulfide isomerase PDI acts as an organizer of cytoskeletal mechanoadaptation in vascular smooth muscle cells

    FASEB JOURNAL, v.32, n.1, suppl.S, 2018