LIM/19 - Laboratório de Histocompatibilidade e Imunidade Celular
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Deciphering Multifactorial Correlations of COVID-19 Incidence and Mortality in the Brazilian Amazon Basin
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, v.19, n.3, article ID 1153, 16p, 2022
Amazonas suffered greatly during the COVID-19 pandemic. The mortality and fatality rates soared and scarcity of oxygen and healthcare supplies led the health system and funerary services to collapse. Thus, we analyzed the trends of incidence, mortality, and lethality indicators of COVID-19 and th...
Data and Safety Monitoring of COVID-19 Vaccine Clinical Trials
JOURNAL OF INFECTIOUS DISEASES, v.224, n.12, p.1995-2000, 2021
To speed the development of vaccines against SARS-CoV-2, the United States Federal Government has funded multiple phase 3 trials of candidate vaccines. A single 11-member data and safety monitoring board (DSMB) monitors all government-funded trials to ensure coordinated oversight, promote harmoni...
Recessive NLRC4-Autoinflammatory Disease Reveals an Ulcerative Colitis Locus
JOURNAL OF CLINICAL IMMUNOLOGY, v.42, n.2, p.325-335, 2022
Purpose NLRC4-associated autoinflammatory disease (NLRC4-AID) is an autosomal dominant condition presenting with a range of clinical manifestations which can include macrophage activation syndrome (MAS) and severe enterocolitis. We now report the first homozygous mutation in NLRC4 (c.478G > A, p....
H is not for hydroxychloroquine-""H"" is for heparin: lack of efficacy of hydroxychloroquine and the role of heparin in COVID-19-preliminary data of a prospective and interventional study from Brazil
BMC INFECTIOUS DISEASES, v.22, n.1, article ID 120, 10p, 2022
Background COVID-19 pandemic is the major public health problem in the world actually. It's associated with high morbidity and mortality. To date, no therapeutic measure has a curative potential. Hydroxychloroquine (HCQ) is a drug with immunomodulatory properties that has demonstrated antiviral e...
Cardiac MicroRNA Expression Profile After Experimental Brain Death Is Associated With Myocardial Dysfunction and Can Be Modulated by Hypertonic Saline
TRANSPLANTATION, v.106, n.2, p.289-298, 2022
Background. Brain death (BD) is associated with systemic inflammatory compromise, which might affect the quality of the transplanted organs. This study investigated the expression profile of cardiac microRNAs (miRNAs) after BD, and their relationship with the observed decline in myocardial functi...
Oxysterols and mesenchymal stem cell biology
HORMONES AND STEM CELLS, v.116, p.409-436, 2021
Mesenchymal stem cells have the ability to differentiate into several cell types when exposed to determined substances, including oxysterols. Oxysterols are cholesterol products derived from its auto-oxidation by reactive species or from enzymatic action. They are present in the body in low quant...
BONE MARROW MESENCHYMAL STEM CELLS DERIVED FROM HEALTHY DONORS BUT NOT THOSE DERIVED FROM ACUTE MYELOID LEUKEMIA PATIENTS ARE ABLE TO AFFECT PROLIFERATION AND DEATH OF LEUKEMIC CELL LINEAGES K562 AND K562 LUCENA
CYTOTHERAPY, v.23, n.4, suppl.S, p.5-5, 2021
HAAAAE (H4AE): Warning signs for early identification of hereditary angioedema
EXPERIMENTAL DERMATOLOGY, v.30, suppl.2, Special Issue, p.7-7, 2021
Scabies masked by systemic mastocytosis
EXPERIMENTAL DERMATOLOGY, v.30, suppl.2, Special Issue, p.9-9, 2021
ONE STEP TECHNIQUETM IS EFFICIENT IN HARVESTING MESENCHYMAL STEM CELLS FROM HUMAN ADIPOSE TISSUE
CYTOTHERAPY, v.23, n.4, suppl.S, p.29-29, 2021