LIM/19 - Laboratório de Histocompatibilidade e Imunidade Celular
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Basophil Activation Test as a Biomarker for Taxanes Anaphylaxis
FRONTIERS IN ALLERGY, v.3, article ID 787749, 9p, 2022
IntroductionTaxanes are widely used chemotherapy agents, and their administration, despite premedication, is associated with hypersensitivity reactions (HR) in up to 9% of patients, 1% of which are severe. The mechanisms of these reactions are not fully understood. Finding biomarkers for early di...
Interview with Prof. Jorge Kalil: The Challenge of Doing Competitive Translational Research in Brazil
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, v.43, n.8, p.315-318, 2023
Up-front Therapy With CHOP Plus Etoposide in Brazilian nodal PTCL Patients: Increased Toxicity and No Survival Benefit Compared to CHOP Regimen–Results of a Real-Life Study From a Middle-Income Country
CLINICAL LYMPHOMA, MYELOMA AND LEUKEMIA, v.22, n.11, p.812-824, 2022
Background: Nodal peripheral T-cell lymphoma (nPTCL) constitute a heterogeneous group of neoplasms with aggressive behavior and poor-survival. They are more prevalent in Latin America and Asia, although data from Brazil are scarce. Its primary therapy is still controversial and ineffective. There...
Multicellular regulation of miR-196a-5p and miR-425-5 from adipose stem cell-derived exosomes and cardiac repair
CLINICAL SCIENCE, v.136, n.17, p.1281-1301, 2022
Cardiac transplantation of adipose-derived stem cells (ASC) modulates the post-myocardial infarction (post-MI) repair response. Biomolecules secreted or shuttled within extracellular vesicles, such as exosomes, may participate in the concerted response. We investigated the exosome’s microRNAs due...
Time-dependent contraction of the SARS-CoV-2–specific T-cell responses in convalescent individuals
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY: GLOBAL, v.1, n.3, p.112-121, 2022
Background: Adaptive immunity in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is decisive for disease control. Delayed activation of T cells is associated with a worse outcome in coronavirus disease 2019 (COVID-19). Although convalescent individuals exhibit solid T-cell ...
Inflammatory cytokines and white matter microstructure in the acute phase of first-episode psychosis: A longitudinal study
SCHIZOPHRENIA RESEARCH, v.257, p.5-18, 2023
Objectives: Schizophrenia-related psychosis is associated with abnormalities in white matter (WM) microstructure and structural brain dysconnectivity. However, the pathological process underlying such changes is unknown. We sought to investigate the potential association between peripheral cytoki...
MiRNA-30d and miR-770-5p as potential clinical risk predictors of Vasoplegic Syndrome in Patients undergoing on-pump coronary artery bypass grafting
SCIENTIFIC REPORTS, v.13, n.1, 2023
The aims of this study were to perform pre-surgery miRNA profiling of patients who develop Vasoplegic syndrome (VS) after coronary artery bypass grafting (CABG) and identify those miRNAs that could be used as VS prognostic tools and biomarkers. The levels of 754 microRNAs (miRNAs) were measured i...
Cognitive impairment in long-COVID and its association with persistent dysregulation in inflammatory markers
FRONTIERS IN IMMUNOLOGY, v.14, article ID 1174020, 13p, 2023
ObjectiveTo analyze the potential impact of sociodemographic, clinical and biological factors on the long-term cognitive outcome of patients who survived moderate and severe forms of COVID-19. MethodsWe assessed 710 adult participants (Mean age = 55 +/- 14; 48.3% were female) 6 to 11 months after...
Peri/epicellular Protein Disulfide Isomerase Reshapes Vascular Architecture to Counteracts Constrictive Remodeling
FREE RADICAL BIOLOGY AND MEDICINE, v.76, suppl.1, p.S54-S54, 2014
Peri/epicellular protein disulfide isomerase PDI acts as an organizer of cytoskeletal mechanoadaptation in vascular smooth muscle cells
FASEB JOURNAL, v.32, n.1, suppl.S, 2018