LIM/19 - Laboratório de Histocompatibilidade e Imunidade Celular

O Laboratório de Histocompatibilidade e Imunidade Celular é ligado ao Departamento de Cardiopneumologia da Faculdade de Medicina da Universidade de São Paulo (FMUSP).

Linhas de pesquisa: atuação focada no estudo do reconhecimento imunológico através do complexo trimolecular – molécula apresentadora (MHC), peptídeo e molécula de reconhecimento (LTCR) – e das consequências de tal reconhecimento, através de uma resposta de defesa ou de regulação; estuda como modelo as doenças do coração: febre reumática, Chagas ou aterosclerose e também o transplante de órgãos.

Site oficial: http://limhc.fm.usp.br/portal/lim19-laboratorio-de-histocompatibilidade-e-imunidade-celular/

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Recent Submissions

  1. Deciphering Multifactorial Correlations of COVID-19 Incidence and Mortality in the Brazilian Amazon Basin

    INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, v.19, n.3, article ID 1153, 16p, 2022

    Amazonas suffered greatly during the COVID-19 pandemic. The mortality and fatality rates soared and scarcity of oxygen and healthcare supplies led the health system and funerary services to collapse. Thus, we analyzed the trends of incidence, mortality, and lethality indicators of COVID-19 and th...

  2. Data and Safety Monitoring of COVID-19 Vaccine Clinical Trials

    JOURNAL OF INFECTIOUS DISEASES, v.224, n.12, p.1995-2000, 2021

    To speed the development of vaccines against SARS-CoV-2, the United States Federal Government has funded multiple phase 3 trials of candidate vaccines. A single 11-member data and safety monitoring board (DSMB) monitors all government-funded trials to ensure coordinated oversight, promote harmoni...

  3. Recessive NLRC4-Autoinflammatory Disease Reveals an Ulcerative Colitis Locus

    JOURNAL OF CLINICAL IMMUNOLOGY, v.42, n.2, p.325-335, 2022

    Purpose NLRC4-associated autoinflammatory disease (NLRC4-AID) is an autosomal dominant condition presenting with a range of clinical manifestations which can include macrophage activation syndrome (MAS) and severe enterocolitis. We now report the first homozygous mutation in NLRC4 (c.478G > A, p....

  4. H is not for hydroxychloroquine-""H"" is for heparin: lack of efficacy of hydroxychloroquine and the role of heparin in COVID-19-preliminary data of a prospective and interventional study from Brazil

    BMC INFECTIOUS DISEASES, v.22, n.1, article ID 120, 10p, 2022

    Background COVID-19 pandemic is the major public health problem in the world actually. It's associated with high morbidity and mortality. To date, no therapeutic measure has a curative potential. Hydroxychloroquine (HCQ) is a drug with immunomodulatory properties that has demonstrated antiviral e...

  5. Cardiac MicroRNA Expression Profile After Experimental Brain Death Is Associated With Myocardial Dysfunction and Can Be Modulated by Hypertonic Saline

    TRANSPLANTATION, v.106, n.2, p.289-298, 2022

    Background. Brain death (BD) is associated with systemic inflammatory compromise, which might affect the quality of the transplanted organs. This study investigated the expression profile of cardiac microRNAs (miRNAs) after BD, and their relationship with the observed decline in myocardial functi...

  6. Oxysterols and mesenchymal stem cell biology

    HORMONES AND STEM CELLS, v.116, p.409-436, 2021

    Mesenchymal stem cells have the ability to differentiate into several cell types when exposed to determined substances, including oxysterols. Oxysterols are cholesterol products derived from its auto-oxidation by reactive species or from enzymatic action. They are present in the body in low quant...

  7. BONE MARROW MESENCHYMAL STEM CELLS DERIVED FROM HEALTHY DONORS BUT NOT THOSE DERIVED FROM ACUTE MYELOID LEUKEMIA PATIENTS ARE ABLE TO AFFECT PROLIFERATION AND DEATH OF LEUKEMIC CELL LINEAGES K562 AND K562 LUCENA

    CYTOTHERAPY, v.23, n.4, suppl.S, p.5-5, 2021

  8. HAAAAE (H4AE): Warning signs for early identification of hereditary angioedema

    EXPERIMENTAL DERMATOLOGY, v.30, suppl.2, Special Issue, p.7-7, 2021

  9. Scabies masked by systemic mastocytosis

    EXPERIMENTAL DERMATOLOGY, v.30, suppl.2, Special Issue, p.9-9, 2021

  10. ONE STEP TECHNIQUETM IS EFFICIENT IN HARVESTING MESENCHYMAL STEM CELLS FROM HUMAN ADIPOSE TISSUE

    CYTOTHERAPY, v.23, n.4, suppl.S, p.29-29, 2021