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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorWERNECK, Andre O.
dc.contributor.authorCHRISTOFARO, Diego G. D.
dc.contributor.authorRITTI-DIAS, Raphael M.
dc.contributor.authorCUCATO, Gabriel G.
dc.contributor.authorSTUBBS, Brendon
dc.contributor.authorOYEYEMI, Adewale L.
dc.contributor.authorCONCEICAO, Raquel D. O.
dc.contributor.authorSANTOS, Raul D.
dc.contributor.authorBITTENCOURT, Marcio S.
dc.date.accessioned2020-08-20T13:20:17Z-
dc.date.available2020-08-20T13:20:17Z-
dc.date.issued2020
dc.identifier.citationPHYSIOLOGY & BEHAVIOR, v.223, article ID 112967, 5p, 2020
dc.identifier.issn0031-9384
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/36740-
dc.description.abstractThis study investigated whether physical activity (PA) influences the association between depression risk and low-grade inflammation. This was a cross-sectional study including 8,048 adults (18-59y). Depression symptoms were evaluated with the Beck depression inventory (BDI) and physical activity through the international physical activity questionnaire. Adults with infectious and inflammatory diseases were excluded. Blood samples were collected, including high sensitivity C-reactive protein (CRP), a marker of low-grade inflammation when >= 3mg/L. Additional measures of LDL-C, HDL-C, triglycerides and fasting glucose were also determined. Sex, chronological age, tobacco smoking, alcohol drinking, body mass index, dyslipidemia, high blood pressure and fasting glucose were used as covariates. Mediation models were conducted using the procedures of Karlson Holm Breen. Adults with elevated CRP (>= 3mg/L) compared to those with low CRP (<3mg/L) presented with higher BDI scores [8.5%(95%CI:7.2%-10.1%) vs. 5.8%(95%CI:5.2-6.4)] as well as higher prevalence of physical inactivity 67.4% (95%CI:64.9-69.9) vs. 59.7% (95%CI:58.4-60.9). The prevalence of elevated CRP was highest in physically inactive adults with greater depression risk. Models revealed that physical activity risk explained 13% of the association between depression risk and elevated CRP (p=0.035), independently of potential confounders. Physical activity may reduce the association between depression symptoms and elevated CRP. Future longitudinal research is required to determine the directionality of the relationships observed.eng
dc.description.sponsorshipSao Paulo Research Foundation (FAPESP)Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2019/24124-7]
dc.language.isoeng
dc.publisherPERGAMON-ELSEVIER SCIENCE LTDeng
dc.relation.ispartofPhysiology & Behavior
dc.rightsrestrictedAccesseng
dc.subjectDepressioneng
dc.subjectInflammationeng
dc.subjectPhysical activityeng
dc.subjectC-reactive proteineng
dc.subject.otherc-reactive proteineng
dc.subject.othersevere mental-illnesseng
dc.subject.othersedentary behavioreng
dc.subject.otherexerciseeng
dc.subject.othermetaanalysiseng
dc.subject.otherdiseaseeng
dc.subject.othersensitivityeng
dc.subject.othercytokineeng
dc.subject.otherpeopleeng
dc.subject.othergendereng
dc.titleDoes physical activity influence the association between depressive symptoms and low-grade inflammation in adults? A study of 8,048 adultseng
dc.typearticleeng
dc.rights.holderCopyright PERGAMON-ELSEVIER SCIENCE LTDeng
dc.identifier.doi10.1016/j.physbeh.2020.112967
dc.identifier.pmid32479805
dc.subject.wosPsychology, Biologicaleng
dc.subject.wosBehavioral Scienceseng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
hcfmusp.author.externalWERNECK, Andre O.:Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, Av Dr Arnaldo 715, BR-01246904 Sao Paulo, SP, Brazil
hcfmusp.author.externalCHRISTOFARO, Diego G. D.:Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, Av Dr Arnaldo 715, BR-01246904 Sao Paulo, SP, Brazil
hcfmusp.author.externalRITTI-DIAS, Raphael M.:Univ Nove Julho, Sao Paulo, Brazil
hcfmusp.author.externalCUCATO, Gabriel G.:Northumbria Univ, Newcastle Upon Tyne, Tyne & Wear, England
hcfmusp.author.externalSTUBBS, Brendon:Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychol Med, De Crespigny Pk, London SE5 8AF, England; South London & Maudsley NHS Fdn Trust, London, England
hcfmusp.author.externalOYEYEMI, Adewale L.:Univ Maiduguri, Coll Med Sci, Dept Physiotherapy, Maiduguri, Borno State, Nigeria
hcfmusp.author.externalCONCEICAO, Raquel D. O.:Hosp Israelita Albert Einstein, Sao Paulo, Brazil
hcfmusp.description.articlenumber112967
hcfmusp.description.volume223
hcfmusp.origemWOS
hcfmusp.origem.idWOS:000550576800009
hcfmusp.origem.id2-s2.0-85085928365
hcfmusp.publisher.cityOXFORDeng
hcfmusp.publisher.countryENGLANDeng
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dc.description.indexMEDLINEeng
hcfmusp.citation.scopus6-
hcfmusp.scopus.lastupdate2022-11-25-
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