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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorALMEIDA, Fabio Augusto Abreu de
dc.contributor.authorDEZAN, Marcia Regina
dc.contributor.authorOLIVEIRA, Valeria Brito
dc.contributor.authorALENCAR, Cecilia Salete
dc.contributor.authorLUZ, Fabio
dc.contributor.authorKRIEGER, Jose Eduardo
dc.contributor.authorPEREIRA, Alexandre Costa
dc.contributor.authorSABINO, Ester Cerdeira
dc.contributor.authorROCHA, Vanderson
dc.contributor.authorMENDRONE-JUNIOR, Alfredo
dc.contributor.authorDINARDO, Carla Luana
dc.date.accessioned2020-08-20T13:20:22Z-
dc.date.available2020-08-20T13:20:22Z-
dc.date.issued2020
dc.identifier.citationTRANSFUSION AND APHERESIS SCIENCE, v.59, n.2, article ID UNSP 102720, 6p, 2020
dc.identifier.issn1473-0502
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/36769-
dc.description.abstractIntroduction: Patients with RH variants presenting antibodies directed to RH high frequency antigens or multiple RH antibodies might, in some occasions, be better served with RH genotype-matched units, requiring screening for RH variants among blood donors. To date, strategies to identify donors with RH variants were restricted to selecting individuals of African descent based on self-reported race, what can be inaccurate in racially mixed population. Our goal was to: 1) Screen for donors with RH variants in a mixed population using self-declared race and Rh phenotype as selection criteria; and 2) Verify if including the Duffy null genotype in the screening algorithm increases its effectiveness. Methods: Brazilian donors were included if self-declared as black and phenotyped as R0r or R1r. All individuals were genotyped for RHCE exons 1, 5, 6 and 7 and for the FY*B c.-67 T > C polymorphism in order to determine the Duffy null genotype. RHD variants were searched for in cases of altered RHCE. Results: Among 2500 blood donors, 217 fulfilled the inclusion criteria and were enrolled. Fifty-three (24.4 %) had a predicted clinically relevant Rh phenotype (partial antigens or lack of high frequency antigens). Twelve donors (5.5 %) had a predicted RhCE phenotype lacking either hrB or hrS. Most cases with predicted lack of high frequency antigens (66.7 %) occurred in donors with the Duffy null genotype. Conclusion: Selecting donors based on self-declared race, Rh phenotype and Duffy null genotype is feasible and effective in identifying RH variants lacking Rh high frequency antigens among racially mixed donors.eng
dc.description.sponsorshipFundacao Pro-Sangue Hemocentro de Sao Paulo, Brazil
dc.language.isoeng
dc.publisherPERGAMON-ELSEVIER SCIENCE LTDeng
dc.relation.ispartofTransfusion and Apheresis Science
dc.rightsrestrictedAccesseng
dc.subjectRHeng
dc.subjectDonorseng
dc.subjectRH variantseng
dc.subjectAlloimmunizationeng
dc.subject.othersickle-cell-diseaseeng
dc.subject.othertransfusion therapyeng
dc.subject.otheralloimmunizationeng
dc.subject.otherphenotypeeng
dc.subject.otheralleleseng
dc.titleEffectiveness of strategies to screen for blood donors with RH variants in a mixed populationeng
dc.typearticleeng
dc.rights.holderCopyright PERGAMON-ELSEVIER SCIENCE LTDeng
dc.identifier.doi10.1016/j.transci.2020.102720
dc.identifier.pmid31980333
dc.subject.wosHematologyeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
hcfmusp.author.externalLUZ, Fabio:Fundacao Prosangue Hemoctr Sao Paulo, Sao Paulo, Brazil
hcfmusp.description.articlenumberUNSP 102720
hcfmusp.description.issue2
hcfmusp.description.volume59
hcfmusp.origemWOS
hcfmusp.origem.idWOS:000538121900020
hcfmusp.origem.id2-s2.0-85078637955
hcfmusp.publisher.cityOXFORDeng
hcfmusp.publisher.countryENGLANDeng
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dc.description.indexMEDLINEeng
hcfmusp.citation.scopus1-
hcfmusp.scopus.lastupdate2022-09-16-
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LIM/46 - Laboratório de Parasitologia Médica


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