LIM/21 - Laboratório de Neuro-imagem em Psiquiatria
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The design, evaluation, and reporting on non-pharmacological cognition-oriented treatments for older adults: Results of a survey of experts
ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS, v.6, n.1, article ID e12024, 16p, 2020
Introduction: Cognitive decline and dementia significantly affect independence and quality of life in older adults; therefore, it is critical to identify effective cognition-oriented treatments (COTs; eg, cognitive training, rehabilitation) that can help maintain or enhance cognitive functioning ...
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Counseling about sudden unexpected death in epilepsy (SUDEP): A global survey of neurologists' opinions
EPILEPSY & BEHAVIOR, v.128, article ID 108570, 7p, 2022
Objective: To investigate the opinions and attitudes of neurologists on the counseling about sudden unex-pected death in epilepsy (SUDEP) worldwide. Methods: Practicing neurologists from around the world were invited to participate in an online survey. On February 18th, 2021, we emailed an invita...
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Different routes of administration in chronic migraine prevention lead to different placebo responses: a meta-analysis
PAIN, v.163, n.3, p.415-424, 2022
Placebo response is a powerful determinant of health outcomes in several disorders. Meta-analysis of clinical trials in pain conditions shows that it can contribute up to 75% of the overall treatment effect. Placebo response deriving from different routes of administration is poorly understood in...
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Use of a Bayesian Network Model to predict psychiatric illness in individuals with 'at risk mental states' from a general population cohort
NEUROSCIENCE LETTERS, v.770, article ID 136358, 6p, 2022
The 'at risk mental state' (ARMS) paradigm has been introduced in psychiatry to study prodromal phases of schizophrenia. With time it was seen that the ARMS state can also precede mental disorders other than schizophrenia, such as depression and anxiety. However, several problems hamper the parad...
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Reproducibility in the absence of selective reporting: An illustration from large-scale brain asymmetry research
HUMAN BRAIN MAPPING, v.43, n.1, Special Issue, p.244-254, 2022
The problem of poor reproducibility of scientific findings has received much attention over recent years, in a variety of fields including psychology and neuroscience. The problem has been partly attributed to publication bias and unwanted practices such asp-hacking. Low statistical power in indi...
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Characterizing neuroanatomic heterogeneity in people with and without ADHD based on subcortical brain volumes
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY, v.62, n.9, p.1140-1149, 2021
Background Attention-deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder. Neuroanatomic heterogeneity limits our understanding of ADHD's etiology. This study aimed to parse heterogeneity of ADHD and to determine whether patient subgroups could be discerned based on su...
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Evidence for similar structural brain anomalies in youth and adult attention-deficit/hyperactivity disorder: a machine learning analysis
TRANSLATIONAL PSYCHIATRY, v.11, n.1, article ID 82, 9p, 2021
Attention-deficit/hyperactivity disorder (ADHD) affects 5% of children world-wide. Of these, two-thirds continue to have impairing symptoms of ADHD into adulthood. Although a large literature implicates structural brain differences of the disorder, it is not clear if adults with ADHD have similar...
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Neurological, Psychiatric, and Psychological Implications of the COVID-19 Pandemic: Protocol for a Large-Scale Umbrella Review of Observational Studies
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, v.19, n.3, article ID 1681, 9p, 2022
The severe acute respiratory syndrome coronavirus 2 disease (SARS-CoV-2) is the most severe manifestation of the coronavirus disease 2019 (COVID-19) pandemic. Accruing evidence indicates that the COVID-19 pandemic may have profound deleterious neurological, psychiatric, and psychological outcomes...
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Subjective sleep parameters in prodromal Alzheimer's disease: a case-control study
BRAZILIAN JOURNAL OF PSYCHIATRY, v.43, n.5, p.510-513, 2021
Objective: People with Alzheimer's disease (AD) dementia have impaired sleep. However, the characteristics of sleep in the early stages of AD are not well known, and studies with the aid of biomarkers are lacking. We assessed the subjective sleep characteristics of non-demented older adults and c...
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Cannabidiol Treatment Improves Glucose Metabolism and Memory in Streptozotocin-Induced Alzheimer's Disease Rat Model: A Proof-of-Concept Study
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.23, n.3, article ID 1076, 10p, 2022
An early and persistent sign of Alzheimer's disease (AD) is glucose hypometabolism, which can be evaluated by positron emission tomography (PET) with F-18-2-fluoro-2-deoxy-D-glucose ([F-18]FDG). Cannabidiol has demonstrated neuroprotective and anti-inflammatory properties but has not been evaluat...
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