LIM/21 - Laboratório de Neuro-imagem em Psiquiatria

O Laboratório de Neuro-imagem em Psiquiatria é ligado ao Departamento de Psiquiatria da Faculdade de Medicina da Universidade de São Paulo (FMUSP).

Linhas de pesquisa: aspectos clínicos e neurobiológicos dos seguintes transtornos neuropsiquiátricos: psicoses, espectro obsessivo-compulsivo, síndrome de Taurette, transtornos depressivos e do espectro bipolar, transtornos associados ao envelhecimento, epilepsia e transtornos mentais associados, transtornos psiquiátricos da infância e transtornos de personalidade. Ênfase na realização de pesquisas de neuroimagem, genética, neurofisiologia e ensaios clínicos.

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Recent Submissions

  1. The design, evaluation, and reporting on non-pharmacological cognition-oriented treatments for older adults: Results of a survey of experts


    Introduction: Cognitive decline and dementia significantly affect independence and quality of life in older adults; therefore, it is critical to identify effective cognition-oriented treatments (COTs; eg, cognitive training, rehabilitation) that can help maintain or enhance cognitive functioning ...

  2. Counseling about sudden unexpected death in epilepsy (SUDEP): A global survey of neurologists' opinions

    EPILEPSY & BEHAVIOR, v.128, article ID 108570, 7p, 2022

    Objective: To investigate the opinions and attitudes of neurologists on the counseling about sudden unex-pected death in epilepsy (SUDEP) worldwide. Methods: Practicing neurologists from around the world were invited to participate in an online survey. On February 18th, 2021, we emailed an invita...

  3. Different routes of administration in chronic migraine prevention lead to different placebo responses: a meta-analysis

    PAIN, v.163, n.3, p.415-424, 2022

    Placebo response is a powerful determinant of health outcomes in several disorders. Meta-analysis of clinical trials in pain conditions shows that it can contribute up to 75% of the overall treatment effect. Placebo response deriving from different routes of administration is poorly understood in...

  4. Use of a Bayesian Network Model to predict psychiatric illness in individuals with 'at risk mental states' from a general population cohort

    NEUROSCIENCE LETTERS, v.770, article ID 136358, 6p, 2022

    The 'at risk mental state' (ARMS) paradigm has been introduced in psychiatry to study prodromal phases of schizophrenia. With time it was seen that the ARMS state can also precede mental disorders other than schizophrenia, such as depression and anxiety. However, several problems hamper the parad...

  5. Reproducibility in the absence of selective reporting: An illustration from large-scale brain asymmetry research

    HUMAN BRAIN MAPPING, v.43, n.1, Special Issue, p.244-254, 2022

    The problem of poor reproducibility of scientific findings has received much attention over recent years, in a variety of fields including psychology and neuroscience. The problem has been partly attributed to publication bias and unwanted practices such asp-hacking. Low statistical power in indi...

  6. Characterizing neuroanatomic heterogeneity in people with and without ADHD based on subcortical brain volumes

    JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY, v.62, n.9, p.1140-1149, 2021

    Background Attention-deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder. Neuroanatomic heterogeneity limits our understanding of ADHD's etiology. This study aimed to parse heterogeneity of ADHD and to determine whether patient subgroups could be discerned based on su...

  7. Evidence for similar structural brain anomalies in youth and adult attention-deficit/hyperactivity disorder: a machine learning analysis

    TRANSLATIONAL PSYCHIATRY, v.11, n.1, article ID 82, 9p, 2021

    Attention-deficit/hyperactivity disorder (ADHD) affects 5% of children world-wide. Of these, two-thirds continue to have impairing symptoms of ADHD into adulthood. Although a large literature implicates structural brain differences of the disorder, it is not clear if adults with ADHD have similar...

  8. Neurological, Psychiatric, and Psychological Implications of the COVID-19 Pandemic: Protocol for a Large-Scale Umbrella Review of Observational Studies


    The severe acute respiratory syndrome coronavirus 2 disease (SARS-CoV-2) is the most severe manifestation of the coronavirus disease 2019 (COVID-19) pandemic. Accruing evidence indicates that the COVID-19 pandemic may have profound deleterious neurological, psychiatric, and psychological outcomes...

  9. Subjective sleep parameters in prodromal Alzheimer's disease: a case-control study

    BRAZILIAN JOURNAL OF PSYCHIATRY, v.43, n.5, p.510-513, 2021

    Objective: People with Alzheimer's disease (AD) dementia have impaired sleep. However, the characteristics of sleep in the early stages of AD are not well known, and studies with the aid of biomarkers are lacking. We assessed the subjective sleep characteristics of non-demented older adults and c...

  10. Cannabidiol Treatment Improves Glucose Metabolism and Memory in Streptozotocin-Induced Alzheimer's Disease Rat Model: A Proof-of-Concept Study

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.23, n.3, article ID 1076, 10p, 2022

    An early and persistent sign of Alzheimer's disease (AD) is glucose hypometabolism, which can be evaluated by positron emission tomography (PET) with F-18-2-fluoro-2-deoxy-D-glucose ([F-18]FDG). Cannabidiol has demonstrated neuroprotective and anti-inflammatory properties but has not been evaluat...