LIM/22 - Laboratório de Patolologia Cardiovascular
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Macrophage Polarization in the Perivascular Fat Was Associated With Coronary Atherosclerosis
JOURNAL OF THE AMERICAN HEART ASSOCIATION, v.11, n.6, article ID e023274, 30p, 2022
Background Inflammation of the perivascular adipose tissue (PvAT) may be related to atherosclerosis; however, the association of polarized macrophages in the pericoronary PvAT with measurements of atherosclerosis components in humans has not been fully investigated. Methods and Results Coronary a...
B and T Lymphocyte Densities Remain Stable With Age in Human Cortex
ASN NEURO, v.13, article ID 17590914211018117, 11p, 2021
One hallmark of human aging is increased brain inflammation represented by glial activation. With age, there is also diminished function of the adaptive immune system, and modest decreases in circulating B- and T-lymphocytes. Lymphocytes traffic through the human brain and reside there in small n...
The severity of neuropsychiatric symptoms is higher in early-onset than late-onset Alzheimer's disease
EUROPEAN JOURNAL OF NEUROLOGY, v.29, n.4, p.957-967, 2022
Background and purpose The faster rates of cognitive decline and predominance of atypical forms in early-onset Alzheimer's disease (EOAD) suggest that neuropsychiatric symptoms could be different in EOAD compared to late-onset AD (LOAD); however, prior studies based on non-biomarker-diagnosed coh...
Undernutrition and Cachexia in Patients with Decompensated Heart Failure and Chagas Cardiomyopathy: Occurrence and Association with Hospital Outcomes
ARQUIVOS BRASILEIROS DE CARDIOLOGIA, v.118, n.1, p.3-10, 2022
Background: Nutritional disorders are common among patients with heart failure (HF) and associated with poor prognosis. Importantly, some populations of patients, like the ones with Chagas disease, are frequently excluded from most analyses. Objective: We sought to study the occurrence of undemut...
TH1 lymphocytes in the perivascular adipose tissue correlate with plaque composition and increase the risk of intraplaque haemorrhages in coronary arteries: an autopsy study
EUROPEAN HEART JOURNAL, v.42, suppl.1, p.1088-1088, 2021
Validity of the Supportive Care Needs Survey Short Form 34 in the Amazon population
ACTA PAULISTA DE ENFERMAGEM, v.34, article ID eAPE02342, 9p, 2021
Objective: To analyze the construct validity of the Supportive Care Needs Survey Short Form 34 (SCNS SF-34) in the population with cancer treated in Manaus, in the Brazilian Amazon region. Methods: Psychometric study carried out in an institution specialized in oncology, from April to June 2016. ...
Tau-driven degeneration of sleep- and wake-regulating neurons in Alzheimer's disease
SLEEP MEDICINE REVIEWS, v.60, article ID 101541, 9p, 2021
Disturbances of the sleep/wake cycle in Alzheimer's disease (AD) are common, frequently precede cognitive decline, and tend to worsen with disease progression. Sleep is critical to the maintenance of homeostatic and circadian function, and chronic sleep disturbances have significant cognitive and...
Reduced synchrony in alpha oscillations during life predicts post mortem neurofibrillary tangle density in early-onset and atypical Alzheimer's disease
ALZHEIMERS & DEMENTIA, v.17, n.12, p.2009-2019, 2021
Introduction Neurophysiological manifestations selectively associated with amyloid beta and tau depositions in Alzheimer's disease (AD) are useful network biomarkers to identify peptide specific pathological processes. The objective of this study was to validate the associations between reduced n...
Use of Raman spectroscopy to evaluate the biochemical composition of normal and tumoral human brain tissues for diagnosis
LASERS IN MEDICAL SCIENCE, v.37, n.1, p.121-133, 2022
Raman spectroscopy was used to identify biochemical differences in normal brain tissue (cerebellum and meninges) compared to tumors (glioblastoma, medulloblastoma, schwannoma, and meningioma) through biochemical information obtained from the samples. A total of 263 spectra were obtained from frag...
Increased levels of TAR DNA-binding protein 43 in the hippocampus of subjects with bipolar disorder: a postmortem study
JOURNAL OF NEURAL TRANSMISSION, v.129, n.1, p.95-103, 2022
Bipolar disorder shares symptoms and pathological pathways with other neurodegenerative diseases, including frontotemporal dementia (FTD). Since TAR DNA-binding protein 43 (TDP-43) is a neuropathological marker of frontotemporal dementia and it is involved in synaptic transmission, we explored th...