LIM/22 - Laboratório de Patolologia Cardiovascular

O Laboratório de Patologia Cardiovascular é ligado ao Departamento de Patologia da Faculdade de Medicina da Universidade de São Paulo (FMUSP).

Linhas de pesquisa: estudo morfofuncional das alterações cardiovasculares; análise das repercussões hemodinâmicas da insuficiência cardíaca congestiva; estudo do manuseio clínico do paciente internado em unidade de terapia intensiva; resposta das células endoteliais à agressão; biologia das neoplasias adrenocorticais; fisiopatologia do envelhecimento; envelhecimento cerebral e demências.

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Recent Submissions

  1. Increased Ratio of B2/B1-like Lymphocytes in the Perivascular Adipose Tissue Could Contribute to Plaque Destabilization in Human Coronary Arteries: Preliminary Results

    CIRCULATION, v.144, suppl.1, 2021

  2. Subcortical Neuronal Correlates of Sleep in Neurodegenerative Diseases

    JAMA NEUROLOGY, v.79, n.5, p.498-508, 2022

    IMPORTANCE Sleep disturbance is common among patients with neurodegenerative diseases. Examining the subcortical neuronal correlates of sleep disturbances is important to understanding the early-stage sleep neurodegenerative phenomena. OBJECTIVES To examine the correlation between the number of i...

  3. Macrophage Polarization in the Perivascular Fat Was Associated With Coronary Atherosclerosis

    JOURNAL OF THE AMERICAN HEART ASSOCIATION, v.11, n.6, article ID e023274, 30p, 2022

    Background Inflammation of the perivascular adipose tissue (PvAT) may be related to atherosclerosis; however, the association of polarized macrophages in the pericoronary PvAT with measurements of atherosclerosis components in humans has not been fully investigated. Methods and Results Coronary a...

  4. B and T Lymphocyte Densities Remain Stable With Age in Human Cortex

    ASN NEURO, v.13, article ID 17590914211018117, 11p, 2021

    One hallmark of human aging is increased brain inflammation represented by glial activation. With age, there is also diminished function of the adaptive immune system, and modest decreases in circulating B- and T-lymphocytes. Lymphocytes traffic through the human brain and reside there in small n...

  5. The severity of neuropsychiatric symptoms is higher in early-onset than late-onset Alzheimer's disease

    EUROPEAN JOURNAL OF NEUROLOGY, v.29, n.4, p.957-967, 2022

    Background and purpose The faster rates of cognitive decline and predominance of atypical forms in early-onset Alzheimer's disease (EOAD) suggest that neuropsychiatric symptoms could be different in EOAD compared to late-onset AD (LOAD); however, prior studies based on non-biomarker-diagnosed coh...

  6. Undernutrition and Cachexia in Patients with Decompensated Heart Failure and Chagas Cardiomyopathy: Occurrence and Association with Hospital Outcomes

    ARQUIVOS BRASILEIROS DE CARDIOLOGIA, v.118, n.1, p.3-10, 2022

    Background: Nutritional disorders are common among patients with heart failure (HF) and associated with poor prognosis. Importantly, some populations of patients, like the ones with Chagas disease, are frequently excluded from most analyses. Objective: We sought to study the occurrence of undemut...

  7. TH1 lymphocytes in the perivascular adipose tissue correlate with plaque composition and increase the risk of intraplaque haemorrhages in coronary arteries: an autopsy study

    EUROPEAN HEART JOURNAL, v.42, suppl.1, p.1088-1088, 2021

  8. Validity of the Supportive Care Needs Survey Short Form 34 in the Amazon population

    ACTA PAULISTA DE ENFERMAGEM, v.34, article ID eAPE02342, 9p, 2021

    Objective: To analyze the construct validity of the Supportive Care Needs Survey Short Form 34 (SCNS SF-34) in the population with cancer treated in Manaus, in the Brazilian Amazon region. Methods: Psychometric study carried out in an institution specialized in oncology, from April to June 2016. ...

  9. Tau-driven degeneration of sleep- and wake-regulating neurons in Alzheimer's disease

    SLEEP MEDICINE REVIEWS, v.60, article ID 101541, 9p, 2021

    Disturbances of the sleep/wake cycle in Alzheimer's disease (AD) are common, frequently precede cognitive decline, and tend to worsen with disease progression. Sleep is critical to the maintenance of homeostatic and circadian function, and chronic sleep disturbances have significant cognitive and...

  10. Reduced synchrony in alpha oscillations during life predicts post mortem neurofibrillary tangle density in early-onset and atypical Alzheimer's disease

    ALZHEIMERS & DEMENTIA, v.17, n.12, p.2009-2019, 2021

    Introduction Neurophysiological manifestations selectively associated with amyloid beta and tau depositions in Alzheimer's disease (AD) are useful network biomarkers to identify peptide specific pathological processes. The objective of this study was to validate the associations between reduced n...