• Specific cortical and subcortical grey matter regions are associated with insomnia severity 

  FALGAS, Neus; ILLAN-GALA, Ignacio; ALLEN, Isabel E.; MUMFORD, Paige; ESSANAA, Youssef M.; LE, Michael M.; YOU, Michelle; GRINBERG, Lea T.; ROSEN, Howard J.; NEYLAN, Thomas C.; KRAMER, Joel H.; WALSH, Christine M. (PUBLIC LIBRARY SCIENCE, SAN FRANCISCO, USA, 2021)

  Background There is an increasing awareness that sleep disturbances are a risk factor for dementia. Prior case-control studies suggested that brain grey matter (GM) changes involving cortical (i.e, prefrontal areas) and ...
• Severe Dementia Predicts Weight Loss by the Time of Death 

  CICILIATI, Aline Maria M.; ADRIAZOLA, Izabela Ono; FARIAS-ITAO, Daniela Souza; PASQUALUCCI, Carlos Augusto; LEITE, Renata Elaine Paraizo; NITRINI, Ricardo; GRINBERG, Lea T.; JACOB-FILHO, Wilson; SUEMOTO, Claudia Kimie (FRONTIERS MEDIA SA, LAUSANNE, SWITZERLAND, 2021)

  Background: Body mass index (BMI) in midlife is associated with dementia. However, the association between BMI and late-life obesity is controversial. Few studies have investigated the association between BMI and cognitive ...
• Active lifestyle enhances protein expression profile in subjects with Lewy body pathology 

  REAL, Caroline Cristiano; SUEMOTO, Cláudia Kimie; BINDA, Karina Henrique; GRINBERG, Lea Tenenholz; PASQUALUCCI, Carlos Augusto; JACOB FILHO, Wilson; FERRETTI-REBUSTINI, Renata Eloah de Lucena; NITRINI, Ricardo; LEITE, Renata Elaine Paraizo; BRITTO, Luiz Roberto de (Associação de Neurologia Cognitiva e do Comportamento, 2021)

  ABSTRACT. Clinical trials of the effects of physical activity have reported improvements in symptoms and quality of life in patients with Parkinson's disease (PD). Additionally, morphological brain changes after exercising ...
• Patterns of neuronal Rhes as a novel hallmark of tauopathies 

  EHRENBERG, Alexander J.; LENG, Kun; LETOURNEAU, Kaitlyn N.; HERNANDEZ, Israel; LEW, Caroline; SEELEY, William W.; SPINA, Salvatore; MILLER, Bruce; HEINSEN, Helmut; KAMPMANN, Martin; KOSIK, Kenneth S.; GRINBERG, Lea T. (SPRINGER, NEW YORK, UNITED STATES, 2021)

  The farnesyltransferase inhibitor, Lonafarnib, reduces tau inclusions and associated atrophy in familial tauopathy models through activation of autophagy, mediated by the inhibition of farnesylation of the Ras GTPase, Rhes. ...
• Are the 50's, the transition decade, in choroid plexus aging? 

  TAHIRA, Ana; MARQUES, Fernanda; LISBOA, Bianca; FELTRIN, Arthur; BARBOSA, Andre; OLIVEIRA, Katia Cristina de; PEREIRA, Carlos Alberto de Braganca; LEITE, Renata; GRINBERG, Lea; SUEMOTO, Claudia; FERRETTI-REBUSTINI, Renata Eloah de Lucena; PASQUALUCCI, Carlos Augusto; JACOB-FILHO, Wilson; BRENTANI, Helena; PALHA, Joana Almeida (SPRINGER, DORDRECHT, NETHERLANDS, 2021)

  The choroid plexus (CP) is an important structure for the brain. Besides its major role in the production of cerebrospinal fluid (CSF), it conveys signals originating from the brain, and from the circulatory system, shaping ...
• NLRP3 and NLRP1 inflammasomes are up-regulated in patients with mesial temporal lobe epilepsy and may contribute to overexpression of caspase-1 and IL-beta in sclerotic hippocampi 

  TOSCANO, Eliana Cristina de Brito; VIEIRA, Erica Leandro Marciano; DIAS, Barbara Boni Rocha; CALIARI, Marcelo Vidigal; GONCALVES, Ana Paula; GIANNETTI, Alexandre Varela; SIQUEIRA, Jose Mauricio; SUEMOTO, Claudia Kimie; LEITE, Renata Elaine Paraizo; NITRINI, Ricardo; RACHID, Milene Alvarenga; TEIXEIRA, Antonio Lucio (ELSEVIER, AMSTERDAM, NETHERLANDS, 2021)

  Inflammation plays a role in the pathophysiology of mesial temporal lobe epilepsy (MLLE). Inflammasome pathways, including the NLRP1 and NLRP3-induced ones, promote neuroinflammation and pyroptosis through interleukin ...
• Evaluation of the diaphragm muscle remodeling, inflammation, oxidative stress and vascularization in smokers: An autopsy study 

  NUCCI, R.A.B.; MAIFRINO, L.B.M.; BUSSE, A.L.; SOUZA, R.R. De; PASQUALUCCI, C.A.; ANARUMA, C.A.; LEITE, R.E.P.; RODRIGUEZ, R.D.; SUEMOTO, C.K.; JACOB-FILHO, W. (CELL PHYSIOL BIOCHEM PRESS GMBH & CO KG, 2020)

  Background/Aims: Cigarette smoking is a key factor in systemic inflammation and oxidative stress, and it has also been associated with the loss of muscle strength and an elevated risk of pulmonary diseases. Thus, this study ...
• Death trends based on autopsy data compared to the beginning of the coronavirus pandemic in Brazil 

  GIMENEZ JUNIOR, G. A. A.; ZILLI, P. K.; SILVA, L. F. F.; PASQUALUCCI, C. A.; CAMPO, A. B.; SUEMOTO, C. K. (ASSOC BRAS DIVULG CIENTIFICA, RIBEIRAO PRETO, BRAZIL, 2021)

  The novel Coronavirus disease (COVID-19) is responsible for thousands of deaths worldwide, especially in Brazil, currently one of the leading countries in number of infections and deaths. The beginning of the COVID-19 ...
• Neuropathological consensus criteria for the evaluation of Lewy pathology in post-mortem brains: a multi-centre study 

  ATTEMS, Johannes; TOLEDO, Jon B.; WALKER, Lauren; GELPI, Ellen; GENTLEMAN, Steve; HALLIDAY, Glenda; HORTOBAGYI, Tibor; JELLINGER, Kurt; KOVACS, Gabor G.; LEE, Edward B.; LOVE, Seth; MCALEESE, Kirsty E.; NELSON, Peter T.; NEUMANN, Manuela; PARKKINEN, Laura; POLVIKOSKI, Tuomo; SIKORSKA, Beata; SMITH, Colin; GRINBERG, Lea Tenenholz; THAL, Dietmar R.; TROJANOWSKI, John Q.; MCKEITH, Ian G. (SPRINGER, NEW YORK, UNITED STATES, 2021)

  Currently, the neuropathological diagnosis of Lewy body disease (LBD) may be stated according to several staging systems, which include the Braak Lewy body stages (Braak), the consensus criteria by McKeith and colleagues ...
• The course of patients with Chagas heart disease during episodes of decompensated heart failure 

  ISSA, Victor Sarli; AYUB-FERREIRA, Silvia Moreira; SCHROYENS, Matthew; CHIZZOLA, Paulo Roberto; SOARES, Paulo Rogerio; LAGE, Silvia Helena Gelas; BOCCHI, Edimar Alcides (WILEY PERIODICALS, INC, SAN FRANCISCO, USA, 2021)

  Aims This study aimed to analyse the clinical presentation and prognosis of patients with Chagas cardiomyopathy and decompensated heart failure (HF), as compared with other aetiologies. Methods and results A prospective ...
• Response letter: neuropathological lesions in the very old 

  SUEMOTO, Claudia K.; LEITE, Renata E. P.; FERRETTI-REBUSTINI, Renata E. L.; RODRIGUEZ, Roberta D.; NITRINI, Ricardo; PASQUALUCCI, Carlos A.; JACOB-FILHO, Wilson; GRINBERG, Lea T. (WILEY, HOBOKEN, USA, 2020)
• Role of the Mevalonate Pathway in Adrenocortical Tumorigenesis 

  LIMA-VALASSI, Helena Panteliou; LERARIO, Antonio Marcondes; MONTENEGRO, Luciana Ribeiro; FRAGOSO, Maria Candida Barisson Villares; ALMEIDA, Madson Queiroz; MENDONCA, Berenice Bilharinho; LIN, Chin Jia (GEORG THIEME VERLAG KG, STUTTGART, GERMANY, 2021)

  3-Hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) is the rate-limiting enzyme of the mevalonate pathway, which generates cholesterol and non-sterol compounds such as isoprenoid, which are involved in key steps of ...
• beta-amyloid pathology is not associated with depression in a large community sample autopsy study 

  SALDANHA, Nanci Moreira; SUEMOTO, Claudia Kimie; RODRIGUEZ, Roberta Diehl; LEITE, Renata Elaine Paraizo; NASCIMENTO, Camila; FERRETI-REBUSTINI, Renata; SILVA, Magnolia Moreira da; PASQUALUCCI, Carlos Augusto; NITRINI, Ricardo; JACOB-FILHO, Wilson; LAFER, Beny; GRINBERG, Lea T.; NUNES, Paula Villela (ELSEVIER, AMSTERDAM, NETHERLANDS, 2021)

  Background: : Depression has been associated with dementia. This study aimed to verify if 13-amyloid Alzheimer's disease-type burden was associated with lifetime major depressive disorder (MDD) and with current depressive ...
• Alcohol Use Disorder is Associated with Upregulation of MicroRNA-34a and MicroRNA-34c in Hippocampal Postmortem Tissue 

  SANTOS-BEZERRA, Daniele P.; CAVALEIRO, Ana Mercedes; SANTOS, Aritania Sousa; SUEMOTO, Claudia Kimie; PASQUALUCCI, Carlos Augusto; JACOB-FILHO, Wilson; LEITE, Renata Elaine Paraizo; PASSARELLI, Marisa; MARIE, Suely Kazue Nagahashi; MACHADO, Ubiratan Fabres; CORREA-GIANNELLA, Maria Lucia (WILEY, HOBOKEN, USA, 2021)

  Background: To investigate epigenetic mechanisms potentially involved in the cognitive decline associated with chronic alcohol intake, we evaluated the expressions of three micro-RNAs (miR-34a, 34b, and -34c) highly expressed ...
• Molecular characterization of selectively vulnerable neurons in Alzheimer's disease 

  LENG, Kun; LI, Emmy; ESER, Rana; PIERGIES, Antonia; SIT, Rene; TAN, Michelle; NEFF, Norma; LI, Song Hua; RODRIGUEZ, Roberta Diehl; SUEMOTO, Claudia Kimie; LEITE, Renata Elaine Paraizo; EHRENBERG, Alexander J.; PASQUALUCCI, Carlos A.; SEELEY, William W.; SPINA, Salvatore; HEINSEN, Helmut; GRINBERG, Lea T.; KAMPMANN, Martin (NATURE RESEARCH, BERLIN, GERMANY, 2021)

  Leng et al. uncover the molecular signature of neuronal subpopulations that are selectively vulnerable to tau aggregation and death early in Alzheimer's disease in the human entorhinal cortex and other brain regions, ...
• A novel temporal-predominant neuro-astroglial tauopathy associated with TMEM106B gene polymorphism in FTLD/ALS-TDP 

  LLIBRE-GUERRA, Jorge J.; LEE, Suzee E.; SUEMOTO, Claudia K.; EHRENBERG, Alexander J.; KOVACS, Gabor G.; KARYDAS, Anna; STAFFARONI, Adam; RESENDE, Elisa De Paula Franca; KIM, Eun-Joo; HWANG, Ji-Hye; RAMOS, Eliana Marisa; WOJTA, Kevin J.; PASQUINI, Lorenzo; PANG, Shirley Yin-Yu; SPINA, Salvatore; ALLEN, Isabel E.; KRAMER, Joel; MILLER, Bruce L.; SEELEY, William W.; GRINBERG, Lea T. (WILEY, HOBOKEN, USA, 2021)

  Polymorphisms in TMEM106B, a gene on chromosome 7p21.3 involved in lysosomal trafficking, correlates to worse neuropathological, and clinical outcomes in frontotemporal lobar degeneration (FTLD) and amyotrophic lateral ...
• Brain arteriolosclerosis 

  BLEVINS, Brittney L.; VINTERS, Harry V.; LOVE, Seth; WILCOCK, Donna M.; GRINBERG, Lea T.; SCHNEIDER, Julie A.; KALARIA, Rajesh N.; KATSUMATA, Yuriko; GOLD, Brian T.; WANG, Danny J. J.; MA, Samantha J.; SHADE, Lincoln M. P.; FARDO, David W.; HARTZ, Anika M. S.; JICHA, Gregory A.; NELSON, Karin B.; MAGAKI, Shino D.; SCHMITT, Frederick A.; TEYLAN, Merilee A.; IGHODARO, Eseosa T.; PHE, Panhavuth; ABNER, Erin L.; CYKOWSKI, Matthew D.; ELDIK, Linda J. Van; NELSON, Peter T. (SPRINGER, NEW YORK, UNITED STATES, 2021)

  Brain arteriolosclerosis (B-ASC), characterized by pathologic arteriolar wall thickening, is a common finding at autopsy in aged persons and is associated with cognitive impairment. Hypertension and diabetes are widely ...
• Proteomic Characterization of Synaptosomes from Human Substantia Nigra Indicates Altered Mitochondrial Translation in Parkinson's Disease 

  PLUM, Sarah; EGGERS, Britta; HELLING, Stefan; STEPATH, Markus; THEISS, Carsten; LEITE, Renata E. P.; MOLINA, Mariana; GRINBERG, Lea T.; RIEDERER, Peter; GERLACH, Manfred; MAY, Caroline; MARCUS, Katrin (MDPI, BASEL, SWITZERLAND, 2020)

  The pathological hallmark of Parkinson's disease (PD) is the loss of neuromelanin-containing dopaminergic neurons within the substantia nigra pars compacta (SNpc). Additionally, numerous studies indicate an altered synaptic ...
• Genome-wide profiling and predicted significance of post-mortem brain microRNA in Alzheimer's disease 

  HENRIQUES, Adriane D.; MACHADO-SILVA, Wilcelly; LEITE, Renata E. P.; SUEMOTO, Claudia K.; LEITE, Katia R. M.; SROUGI, Miguel; PEREIRA, Alexandre C.; JACOB-FILHO, Wilson; NOBREGA, Otavio T. (ELSEVIER IRELAND LTD, CLARE, IRELAND, 2020)

  Background: MicroRNAs (miRNAs) emerged as regulatory elements, with up to 70 % of all miRNAs found in the brain, playing key roles in the onset of Alzheimer's disease (AD). Objective: to broadly assess the expression levels ...
• A possible association between fructose consumption and pulmonary emphysema (vol 9, 9344, 2019) 

  SUEHIRO, Camila Liyoko; TOLEDO-ARRUDA, Alessandra Choqueta de; VIEIRA, Rodolfo de Paula; ALMEIDA, Francine Maria de; OLIVO, Clarice Rosa; MARTINS, Milton de Arruda; LIN, Chin Jia (NATURE RESEARCH, BERLIN, GERMANY, 2020)

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